Q8BH88
Gene name |
Depdc1b |
Protein name |
DEP domain-containing protein 1B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:218581 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BH88
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BH88-F1 | Predicted | AlphaFoldDB |
25 variants for Q8BH88
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs260497296 | 5 | V>I | No | EVA | |
| rs3389300684 | 22 | E>K | No | EVA | |
| rs3389286280 | 23 | L>P | No | EVA | |
| rs3389286269 | 37 | F>I | No | EVA | |
| rs3389305222 | 42 | H>L | No | EVA | |
| rs3389309692 | 45 | T>I | No | EVA | |
| rs3403927725 | 81 | K>R | No | EVA | |
| rs3389299936 | 99 | D>G | No | EVA | |
| rs218667503 | 130 | E>D | No | EVA | |
| rs3389303243 | 212 | V>D | No | EVA | |
| rs3389276580 | 216 | F>C | No | EVA | |
| rs3389304982 | 274 | T>I | No | EVA | |
| rs226423041 | 307 | T>M | No | EVA | |
| rs258171470 | 314 | L>I | No | EVA | |
| rs3389300750 | 371 | V>L | No | EVA | |
| rs224004596 | 378 | A>G | No | EVA | |
| rs29879029 | 398 | A>V | No | EVA | |
| rs3404622945 | 407 | V>M | No | EVA | |
| rs3389230518 | 416 | K>N | No | EVA | |
| rs3389295888 | 422 | M>L | No | EVA | |
| rs3389314260 | 426 | L>M | No | EVA | |
| rs3389309783 | 438 | E>* | No | EVA | |
| rs29884548 | 460 | I>V | No | EVA | |
| rs3389318663 | 476 | Q>* | No | EVA | |
| rs231805557 | 493 | E>D | No | EVA |
No associated diseases with Q8BH88
No regional properties for Q8BH88
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BH88 | |||
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| positive regulation of Wnt signaling pathway | Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZLD2 | DEPDC1B | DEP domain-containing protein 1B | Gallus gallus (Chicken) | PR |
| Q5TB30 | DEPDC1 | DEP domain-containing protein 1A | Homo sapiens (Human) | PR |
| Q8WUY9 | DEPDC1B | DEP domain-containing protein 1B | Homo sapiens (Human) | PR |
| Q21341 | let-99 | Protein let-99 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHRVVGPGP | YRATRLWNET | VELFRARMPL | RRHRCRFKSY | EHCFTASEAV | DWLHELLRNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QNFGPEVTRK | QTVQLLGKFL | KNHVIEDIKG | KWGQEDFEDN | RHLYRFPPSS | PLKPYPKKPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YQRDVIKFPE | WNDPPPGTSQ | ENIPVRPIVM | NSEMWFKRHS | IAIGEVPACR | LVHRRQLTEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVEEIWKSTT | LSYLQKILGL | DSLEEVLNTK | LVSSKFIIHN | VYSVSKQGVV | ILDDKSKELP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HWVLSAMKCL | ANWPNCTDWK | QPMYLGFEKD | VFKTIADYYG | HLKEPLLTFH | LFDAFVSVLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLPKEKTAIE | AFQLCCLLLP | PENRRKLQLL | MRMMARICLN | KEMPPLSDGF | GTRTLMVQTF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SRCILCSKDE | VDLDELLAAR | LVTFLMDNYQ | EILKVPLALQ | TSIEERVAHL | RRVQIKYPGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DMDITLSAPS | FCRQISPEEF | EYQRAYGSQE | PLAALLEEVI | ADDKLSSKEK | KKKLKQFQKS |
| 490 | 500 | 510 | 520 | ||
| YPEVYQERFP | TPESEALLFP | EKPKAKPQLF | MWALRKPFQP | FQRTRSFRM |