Q21341

PR
Gene name
let-99 (K08E7.3)
Protein name
Protein let-99
Names
Lethal protein 99
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K08E7.3
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-344 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q21341

Entry ID Method Resolution Chain Position Source
AF-Q21341-F1 Predicted AlphaFoldDB

No variants for Q21341

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q21341

No associated diseases with Q21341

No regional properties for Q21341

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q21341

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cell cortex
  • Enriched at the cell cortex during both meiosis and mitosis (PubMed:12223405)
  • Enriched asymmetrically at the cell cortex in 1-cell embryos (PubMed:14534135)
  • Localizes at the contact site between EMS and P2 in interphase and is excluded from the contact site during prophase (PubMed:14534135)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLD2 DEPDC1B DEP domain-containing protein 1B Gallus gallus (Chicken) PR
Q8WUY9 DEPDC1B DEP domain-containing protein 1B Homo sapiens (Human) PR
Q5TB30 DEPDC1 DEP domain-containing protein 1A Homo sapiens (Human) PR
Q8BH88 Depdc1b DEP domain-containing protein 1B Mus musculus (Mouse) PR
10 20 30 40 50 60
MSADYSSEKF KATHLFDEIL WHFRSNLSLK TNRRGLATAE NSFSGKEAVD FLMIEMPRII
70 80 90 100 110 120
PNNVPERDKM QKFLEFMMDM NVISEAFPKK VKQRRPFSES RIYLFMKTLD ELKHPKPRSR
130 140 150 160 170 180
RSASFSGARK SAKVAQPASP AATMHRPPKA RLPRRLSRSN GNIDKAGIDN SSGGVENHGF
190 200 210 220 230 240
DDHKDDEIPK KQRTPKILNR SLESICTEEY TEKREVSEMK EKVYDWLPFF KSRRNHTKVN
250 260 270 280 290 300
QPTRRSASLD RNHCVLEQEK AEAALRSQKV TTPPIREAPK DVVFMHPQGP LPAVPSRYQN
310 320 330 340 350 360
HRTSIAGSNP ALLSRGRMYE SIMRRSSVVP VADSVQANNE CSFWKTELLG RLEQIYDRTL
370 380 390 400 410 420
PCEWASKVDG YDIQWNMIEI DHADGIVKSR CQGLQPDYPQ TVIQFMDYLV RYPFVTHKKM
430 440 450 460 470 480
DTGLEYNVNR IFITLVNRLE DLNAPLQFDE CSLIVNLLCK IDSFAAMLDN GPARRWSKVM
490 500 510 520 530 540
ISSSASSIEE AGLMVDGFSR DLPACGIRAS KYRRRALSPF DNRVNLEIQD EKSYEIREQW
550 560 570 580 590 600
LIEAIQLVLL SLPTSRRRKL HKFVTFIQSI ETNAVFDLAD PSNGSSNNRE AAIIGLWTGV
610 620 630 640 650 660
CSKCRKQQGM LITAVLLANF QSLFAVPVEF IEQVKRLECE EKDRYSGPRY AKITRSRNDW
670 680 690
QPPVPDKPQA SPAVFKKPLR EVACEKTKKG LFTRLLRK