Q8BH31
Gene name |
Mfsd8 |
Protein name |
Major facilitator superfamily domain-containing protein 8 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72175 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BH31
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BH31-F1 | Predicted | AlphaFoldDB |
18 variants for Q8BH31
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388612052 | 8 | A>V | No | EVA | |
| rs248503529 | 25 | S>G | No | EVA | |
| rs51812710 | 26 | E>A | No | EVA | |
| rs263823590 | 34 | K>R | No | EVA | |
| rs3388629685 | 44 | Y>F | No | EVA | |
| rs3388630127 | 67 | K>* | No | EVA | |
| rs3388626173 | 129 | A>S | No | EVA | |
| rs3388629647 | 229 | I>N | No | EVA | |
| rs264044694 | 281 | L>F | No | EVA | |
| rs50019772 | 313 | L>F | No | EVA | |
| rs3388630098 | 343 | G>* | No | EVA | |
| rs3388626179 | 346 | V>G | No | EVA | |
| rs3388631848 | 353 | F>C | No | EVA | |
| rs49942776 | 391 | S>P | No | EVA | |
| rs3388618282 | 414 | V>E | No | EVA | |
| rs3388631854 | 439 | Y>F | No | EVA | |
| rs47866019 | 491 | G>V | No | EVA | |
| rs47670909 | 508 | V>I | No | EVA |
No associated diseases with Q8BH31
1 regional properties for Q8BH31
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 39 - 508 | IPR020846 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome maturation | Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. |
| lysosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. |
| neuron development | The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| regulation of autophagy | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| regulation of lysosomal protein catabolic process | Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. |
| TORC1 signaling | A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0JAW2 | Os04g0573000 | SPX domain-containing membrane protein Os04g0573000 | Oryza sativa subsp japonica (Rice) | PR |
| Q6EPQ3 | Os02g0678200 | SPX domain-containing membrane protein Os02g45520 | Oryza sativa subsp japonica (Rice) | PR |
| Q2V4F9 | At1g63010 | SPX domain-containing membrane protein At1g63010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANLGSEAER | EPLLGPGSPG | SREWSEIETQ | EHYKSRWKSV | RILYLTMFLS | SVGFSIVIMS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IWPYLQKIDQ | TADASFLGWV | IASYSLGQMV | ASPLFGLWSN | YRPRKEPLIV | SISISVAANC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LYAYVHVPAA | HNKYYMLIAR | GLVGFGAGNV | AVVRSYIAGA | TSLQERTNAM | ANTSTCQALG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FILGPVFQTC | FALIGEKGVT | WDIIKLQVNM | YTAPVLLAAF | LGILNIILIL | FILREHRVDD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGRQCKSVNF | QEENTDEPQI | PEGSIDQVAV | VATNIVFFVV | LFIFAVYETI | LTPLTLDMYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WTQEQAVLYD | GILLVAFGVE | AVLVFMGVKL | LSKKIGERAI | LLGGFVVVWV | GFFILLPWGN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QFPKIQWEDL | HNSSTPNTTF | GEIIIGLWNS | SREDHSEQPT | GCPIEQTWCL | YTPVIHLAQF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LTAAVLIGTG | YPACSVMSYT | LYSKVLGPKP | QGIYMGWLTT | SGSAARILGP | VFISHVYTYL |
| 490 | 500 | 510 | |||
| GPRWAFSLVC | GIVVLTILLI | GAVYKRLVAF | SVRYMRIQE |