AiPD: Autoinhibited Protein Database

Gene name	Nars2
Protein name	Probable asparagine--tRNA ligase, mitochondrial
Names	Asparaginyl-tRNA synthetase, AsnRS
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:244141
EC number	6.1.1.22: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-57 (Predicted disordered autoinhibitory region) PR

1-57 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BGV0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs46115553	40	R>S	No	EVA
rs3388926092	42	E>V	No	EVA
rs3388919074	49	W>C	No	EVA
rs253494876	77	A>V	No	EVA
rs50331966	99	V>F	No	EVA
rs3388926097	146	R>K	No	EVA
rs258397675	153	G>S	No	EVA
rs3388927499	161	E>D	No	EVA
rs3388923717	174	G>S	No	EVA
rs3388884601	202	K>*	No	EVA
rs216122158	205	G>V	No	EVA
rs249388746	207	K>E	No	EVA
rs3388927000	220	S>P	No	EVA
rs3388927321	253	L>Q	No	EVA
rs226062405	282	A>V	No	EVA
rs1135096374	284	T>M	No	EVA
rs259940122	301	F>L	No	EVA
rs37905624	361	N>K	No	EVA
rs3388923543	372	E>G	No	EVA
rs3388920730	373	L>H	No	EVA
rs3388926031	426	K>N	No	EVA
rs3388927344	470	R>W	No	EVA

Type	Name	Position	InterPro Accession
domain	Aminoacyl-tRNA synthetase, class II (D/K/N)	137 - 471	IPR004364
domain	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type	44 - 118	IPR004365
domain	Aminoacyl-tRNA synthetase, class II	156 - 467	IPR006195

		Description
EC Number	6.1.1.22	Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization	Mitochondrion matrix Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
asparagine-tRNA ligase activity	Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nucleic acid binding	Binding to a nucleic acid.

Name	Definition
asparaginyl-tRNA aminoacylation	The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P25345	SLM5	Asparagine--tRNA ligase, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q96I59	NARS2	Probable asparagine--tRNA ligase, mitochondrial	Homo sapiens (Human)	PR
Q8BIP0	Dars2	Aspartate--tRNA ligase, mitochondrial	Mus musculus (Mouse)	PR
Q9SW95	SYNC2	Asparagine--tRNA ligase, cytoplasmic 2	Arabidopsis thaliana (Mouse-ear cress)	PR