Q9SW95
Gene name |
SYNC2 |
Protein name |
Asparagine--tRNA ligase, cytoplasmic 2 |
Names |
Asparaginyl-tRNA synthetase 2, AsnRS 2, AtNS2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G07420 |
EC number |
6.1.1.22: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SW95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SW95-F1 | Predicted | AlphaFoldDB |
28 variants for Q9SW95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_2376629_T_G | 6 | K>Q | No | 1000Genomes | |
| ENSVATH13882840 | 10 | K>N | No | 1000Genomes | |
| ENSVATH10543253 | 39 | S>N | No | 1000Genomes | |
| ENSVATH10543252 | 43 | A>G | No | 1000Genomes | |
| tmp_3_2376509_C_T | 46 | A>T | No | 1000Genomes | |
| ENSVATH05790769 | 61 | A>G | No | 1000Genomes | |
| ENSVATH05790768 | 69 | P>L | No | 1000Genomes | |
| ENSVATH05790767 | 71 | L>P | No | 1000Genomes | |
| ENSVATH05790764 | 75 | A>V | No | 1000Genomes | |
| tmp_3_2376390_T_G | 85 | Q>H | No | 1000Genomes | |
| ENSVATH00311256 | 90 | A>T | No | 1000Genomes | |
| ENSVATH05790759 | 158 | D>N | No | 1000Genomes | |
| tmp_3_2376049_C_T | 164 | V>I | No | 1000Genomes | |
| ENSVATH05790758 | 177 | V>I | No | 1000Genomes | |
| ENSVATH05790758 | 177 | V>L | No | 1000Genomes | |
| ENSVATH10543247 | 187 | A>P | No | 1000Genomes | |
| ENSVATH00311254 | 298 | Q>K | No | 1000Genomes | |
| ENSVATH10543242 | 354 | K>I | No | 1000Genomes | |
| ENSVATH10543241 | 375 | R>C | No | 1000Genomes | |
| tmp_3_2375209_A_C | 400 | F>L | No | 1000Genomes | |
| ENSVATH13882838 | 434 | M>I | No | 1000Genomes | |
| ENSVATH10543236 | 494 | A>V | No | 1000Genomes | |
| ENSVATH05790753 | 536 | K>R | No | 1000Genomes | |
| tmp_3_2374563_G_T | 537 | Q>K | No | 1000Genomes | |
| ENSVATH13882837 | 578 | R>T | No | 1000Genomes | |
| tmp_3_2374359_G_C | 579 | I>M | No | 1000Genomes | |
| tmp_3_2374349_C_T | 583 | G>R | No | 1000Genomes | |
| ENSVATH05790749 | 623 | I>M | No | 1000Genomes |
No associated diseases with Q9SW95
1 regional properties for Q9SW95
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (D/K/N) | 369 - 631 | IPR004364 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.22 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| asparagine-tRNA ligase activity | Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| asparaginyl-tRNA aminoacylation | The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25345 | SLM5 | Asparagine--tRNA ligase, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q96I59 | NARS2 | Probable asparagine--tRNA ligase, mitochondrial | Homo sapiens (Human) | PR |
| Q8BGV0 | Nars2 | Probable asparagine--tRNA ligase, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESHGKTHQK | EHDNDLSPKP | ITLSKYSKRV | ELKTLLDRSD | RGAGLAGKRV | VIGGWVKSAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVKKNSPPPP | LPVVAAPSPS | SGGDQAHTTA | NIRCTEIIQS | KMNIFKRFFD | VLSGGGKTYP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IFDKTELAGQ | KAVPPPEYVF | YFLISDGSSI | SSLQVVVDSA | LSTVPATQLM | ALGTCIVAEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLRLPLAASA | KHVIELEAEK | LLHVGTVDPE | KYPLSKKQLP | LHMLRDFSHF | RPRTTTVGSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TRVHSALTLA | SHTFLQYHGF | QYVQVPVITT | TTGFGEMFRV | TTLLGKTDDK | EEKKPPVQEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DGFSIDTVKA | VIKEKTRLID | HLKRSDSNRE | TVVAAVHDLK | KTNDLASQIE | MKQKSKTGTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VKPEKLDFSK | DFFGRDTYLT | ASGRFHLESY | ASALGKVYTF | GPRFIADKID | NARHLAEKWN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VETEMAFAEL | DDAMDCADEY | FKFLCKYVLE | NRDEDMKFIS | KRVDKTITTR | LEATASSSLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFSYTEVISL | LQKATTTKFE | TKPEWGVALT | TEHLSYLTDE | IYKGPVIVHT | YPKAIKQFYV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RLNDDKKTVA | AFDLVVPKVG | VVITGSQNEE | RFEILDARIG | ESGFTREKFE | WYLDLRRHGT |
| 610 | 620 | 630 | |||
| VKHSGISLSM | EQMLLYATGL | PDIKDAIPFP | RSWGKANN |