Q8BGA9

PR
Gene name
Oxa1l
Protein name
Mitochondrial inner membrane protein OXA1L
Names
Oxidase assembly 1-like protein, OXA1-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69089
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

313-433 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BGA9

Entry ID Method Resolution Chain Position Source
AF-Q8BGA9-F1 Predicted AlphaFoldDB

25 variants for Q8BGA9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs46935505 18 P>L No EVA
rs264363300 20 R>P No EVA
rs3389324677 28 S>F No EVA
rs3389324704 38 A>T No EVA
rs31285817 42 G>S No EVA
rs3389318523 46 P>S No EVA
rs30434980 48 C>Y No EVA
rs50886432 77 I>V No EVA
rs50657011 104 P>L No EVA
rs1133214105 144 V>A No EVA
rs3389282712 186 D>Y No EVA
rs3389322894 212 L>I No EVA
rs3389329929 221 V>I No EVA
rs3405220265 234 N>H No EVA
rs3389329716 243 G>D No EVA
rs3389318529 263 V>I No EVA
rs3389327457 269 W>* No EVA
rs3389338640 292 I>N No EVA
rs3389338615 308 S>L No EVA
rs3389329785 312 M>L No EVA
rs3389322898 326 A>V No EVA
rs3389318510 400 P>H No EVA
rs3389309919 401 L>Q No EVA
rs3405169964 406 P>Q No EVA
rs3389338592 412 A>V No EVA

No associated diseases with Q8BGA9

1 regional properties for Q8BGA9

Type Name Position InterPro Accession
domain Membrane insertase YidC/Oxa/ALB, C-terminal 135 - 327 IPR028055

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

3 GO annotations of molecular function

Name Definition
membrane insertase activity Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
mitochondrial ribosome binding Binding to a mitochondrial ribosome.
protein homodimerization activity Binding to an identical protein to form a homodimer.

8 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
mitochondrial proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.
negative regulation of ATP-dependent activity Any process that stops or reduces the rate of an ATP-dependent activity.
negative regulation of oxidoreductase activity Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
protein insertion into membrane The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
protein insertion into mitochondrial inner membrane from matrix The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.
protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYV3 OXA1L Mitochondrial inner membrane protein OXA1L Bos taurus (Bovine) PR
Q15070 OXA1L Mitochondrial inner membrane protein OXA1L Homo sapiens (Human) PR
10 20 30 40 50 60
MARNLVCGRW QLLRLLRPQR SYHSVAVSLR PLAAELLAAR RGNGRPPCAL LAVFTPRCIS
70 80 90 100 110 120
TSATLFAEAQ VQAPPVIPAT SIPAAVPEVA SGGAADVVQC ATEPSFTELG LGSYTPVGLI
130 140 150 160 170 180
QNLLEYIHVD LGLPWWGAIA TCTVLARCLV FPLIVKGQRE AAKIHNHMPE MQKFSARIRE
190 200 210 220 230 240
AKLAGDQAEF YKATIEMTRY QKKHDIKLLR PLILPLTQAP VFISFFIALR EMANLPVPSL
250 260 270 280 290 300
QTGGLWWFQD LTVSDPIYVL PLVVTATMWC VLELGAETGV QSNDLQFMRN IIRVMPLVVL
310 320 330 340 350 360
PVTIHFPSAV FMYWLSSNVF SLCQVACLRI PAVRTVLKIP QRVVHDPDKL PPREGFLKSF
370 380 390 400 410 420
KKGWKNAEIA QQLREREQRM QKHLDLAARG PLRQTFTHNP LLQHDPSHPP KAPNSNNSSI
430
KANAKKPWQD TLG