Q8BG67
Gene name |
Efr3a |
Protein name |
Protein EFR3 homolog A |
Names |
Protein EFR3-like |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76740 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BG67
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BG67-F1 | Predicted | AlphaFoldDB |
21 variants for Q8BG67
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389369973 | 10 | S>F | No | EVA | |
| rs3389369965 | 88 | C>S | No | EVA | |
| rs3389343326 | 145 | S>C | No | EVA | |
| rs3389365145 | 155 | H>L | No | EVA | |
| rs3389373814 | 171 | G>V | No | EVA | |
| rs212759376 | 210 | E>D | No | EVA | |
| rs3389357815 | 219 | S>F | No | EVA | |
| rs3389353239 | 221 | P>L | No | EVA | |
| rs3389373902 | 300 | L>F | No | EVA | |
| rs3389357828 | 333 | T>I | No | EVA | |
| rs3404663790 | 340 | T>S | No | EVA | |
| rs3406180855 | 341 | L>V | No | EVA | |
| rs38499092 | 364 | V>I | No | EVA | |
| rs221212932 | 366 | V>L | No | EVA | |
| rs3389365162 | 368 | S>C | No | EVA | |
| rs3406307066 | 484 | L>R | No | EVA | |
| rs3389361883 | 500 | I>K | No | EVA | |
| rs3389284643 | 618 | H>Y | No | EVA | |
| rs13459464 | 705 | V>G | No | EVA | |
| rs3389373887 | 774 | D>N | No | EVA | |
| rs38193824 | 806 | V>I | No | EVA |
No associated diseases with Q8BG67
No regional properties for Q8BG67
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BG67 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cornified envelope | A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y2G0 | EFR3B | Protein EFR3 homolog B | Homo sapiens (Human) | PR |
| Q14156 | EFR3A | Protein EFR3 homolog A | Homo sapiens (Human) | PR |
| Q6ZQ18 | Efr3b | Protein EFR3 homolog B | Mus musculus (Mouse) | PR |
| Q5SPP5 | efr3b | Protein EFR3 homolog B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTRVCCCCS | ALRPRYKRLV | DNIFPEDPKD | GLVKADMEKL | TFYAVSAPEK | LDRIGAYLAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLSRDVVRHR | SGYVLIAMEA | LDQLLMACHS | QSIKPFVESF | LHMVAKLLES | GEPKLQVLGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NSFVKFANIE | EDTPSYHRRY | DFFVSRFSAM | CHSCHSDPEI | RTEIRIAGIR | GIQGVVRKTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NDELRATIWE | PQHMDKIVPS | LLFNMQKIEE | VDSRLGPPSS | PSAADKEENP | AVLAESCFRE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLGRATFGNM | NNAVRPVFAH | LDHHKLWDPN | EFAVHCFKII | MYSIQAQYSH | HVIQEILGHL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DARRKDSPRV | RAGIIQVLLE | AVAIAAKGSI | GPTVLEVFNT | LLKHLRLSVE | LEANDSQKGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VGSVTVSSKD | NDEKIVQNAV | IQTIGFFGSN | LPDYQRSEIM | MFIMGKVPVF | GTSTHTLDIS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLGDLGTRRI | QIMLLRSLLM | VTSGYKAKTI | VTALPGSFLD | PLLSPSLMED | YELRQLVLEV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MHNLMDRHDN | RAKLRGIRII | PDVADLKIKR | EKICRQDTSF | MKKNGQQLYR | HIYLGCKEED |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NVQKNYELLY | TSLALITIEL | ANEEVVIDLI | RLAIALQDSA | IINEDNLSMF | HRCGIMALVA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AYLNFVSQMI | AVPAFCQHVS | KVIETRTMEA | PYFLPEHIFR | DKCMLPKSLE | KHDKNLYFLT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NKIAESLGGS | GYSVERLTVP | YVPQVTDEDR | LSRRKSIVDT | VSIQVDILSN | SVPSDDVVSN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TEEITFEALK | KAIDTNGMEE | QEKEKRRLVI | EKFQKAPFEE | IAAQCESKAN | LLHDRLAQIL |
| 790 | 800 | 810 | |||
| ELTIRPPPSP | SGTLTVTSGH | TQYQSVPVYE | MKFPDLCVY |