Q6ZQ18
Gene name |
Efr3b (Kiaa0953) |
Protein name |
Protein EFR3 homolog B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:668212 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6ZQ18
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6ZQ18-F1 | Predicted | AlphaFoldDB |
30 variants for Q6ZQ18
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389237331 | 17 | R>S | No | EVA | |
| rs3389243996 | 33 | K>N | No | EVA | |
| rs3389243957 | 140 | D>V | No | EVA | |
| rs3389190594 | 165 | M>T | No | EVA | |
| rs3389237255 | 177 | K>R | No | EVA | |
| rs3389221212 | 191 | Q>R | No | EVA | |
| rs3389226898 | 201 | L>H | No | EVA | |
| rs3389221214 | 218 | L>F | No | EVA | |
| rs3389221199 | 252 | I>N | No | EVA | |
| rs3389198623 | 313 | V>M | No | EVA | |
| rs3389240128 | 321 | I>F | No | EVA | |
| rs3389226854 | 322 | I>V | No | EVA | |
| rs3413055148 | 390 | P>S | No | EVA | |
| rs3389243958 | 441 | G>V | No | EVA | |
| rs3389198624 | 462 | T>I | No | EVA | |
| rs3389221186 | 465 | M>V | No | EVA | |
| rs386886071 | 510 | C>S | No | EVA | |
| rs3389161412 | 514 | D>N | No | EVA | |
| rs3389221133 | 589 | R>H | No | EVA | |
| rs3411437289 | 613 | C>R | No | EVA | |
| rs3402968632 | 633 | E>D | No | EVA | |
| rs3402995397 | 633 | E>Q | No | EVA | |
| rs3389221168 | 664 | L>M | No | EVA | |
| rs3389229486 | 681 | Q>E | No | EVA | |
| rs3389231723 | 692 | K>* | No | EVA | |
| rs3389229483 | 731 | V>A | No | EVA | |
| rs3389202763 | 733 | S>C | No | EVA | |
| rs3389202753 | 741 | R>L | No | EVA | |
| rs3389216099 | 743 | R>W | No | EVA | |
| rs3389226923 | 809 | M>I | No | EVA |
No associated diseases with Q6ZQ18
No regional properties for Q6ZQ18
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6ZQ18 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q14156 | EFR3A | Protein EFR3 homolog A | Homo sapiens (Human) | PR |
| Q9Y2G0 | EFR3B | Protein EFR3 homolog B | Homo sapiens (Human) | PR |
| Q8BG67 | Efr3a | Protein EFR3 homolog A | Mus musculus (Mouse) | PR |
| Q5SPP5 | efr3b | Protein EFR3 homolog B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYGVCGCCGA | LRPRYKRLVD | NIFPEDPEDG | LVKTNMEKLT | FYALSAPEKL | DRIGAYLSER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LIRDVGRHRY | GYVCIAMEAL | DQLLMACHCQ | SINLFVESFL | KMVAKLLESE | KPNLQILGTN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SFVKFANIEE | DTPSYHRSYD | FFVSRFSEMC | HSSHDDLEIK | TKIRMSGIKG | LQGVVRKTVN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DELQANIWDP | QHMDKIVPSL | LFNLQHVEEA | ESRSPSPLQA | PEKEKENPAE | LAERCLRELL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRAAFGNIKN | AIKPVLIHLD | NHSLWEPKVF | ATRCFKIIMY | SIQPQHSHLV | IQQLLSHLDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSRSAATVRA | GIVEVLSEAA | IIAATGSVGP | TVLEMFNTLL | RQLRLSIDYA | LTGSYDGAVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGSKIIKEHE | ECMFQEAVIK | TIGSFASTLP | TYQRSEVILF | IMSKVPLPSV | HHPVETGRTG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ENRNRLTQIM | LLKSLLQVST | GFQCNNMMSA | LPSNFLDRLL | STALMEDAEI | RLFVLEILIS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FIDRHGNRHK | FSTISTLGDI | SVLKLKVDKC | SRQDTVFMKK | HSQQLYRHIY | LSCKEETNIQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KHYEALYGLL | ALISIELANE | EVVVDLIRLV | LAVQDVAQVN | EENLPTYNRC | ALYALGAAYL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NLISQLTTVP | AFCQHIHEVI | ETRKKEAPYM | LPEDVFVEKP | RLSQNLDGVV | IEFLFRQSKI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SEVLGGSGYN | SDRLCLPYIP | QLTDEDRLSK | RKSIGETISL | QVEVESRNSP | EKEERVPAEE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ITYETLKKAI | VDSVAVEEQE | RERQRQVVEK | FQKAPFEEIA | AHCGARASLL | QSKLNQIFEI |
| 790 | 800 | 810 | |||
| TIRPPPSPSG | TISAAYGQPQ | NHSIPVYEMK | FPDLCVY |