Q8AWC3

PR
Gene name
ARC
Protein name
Activity-regulated cytoskeleton-associated protein
Names
Activity-regulated gene 3.1 protein homolog, ARC/ARG3.1, Arg3.1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395075
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

320-404 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8AWC3

Entry ID Method Resolution Chain Position Source
AF-Q8AWC3-F1 Predicted AlphaFoldDB

14 variants for Q8AWC3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs733433927 8 N>T No Ensembl
rs736072957 44 T>P No Ensembl
rs739451687 47 H>P No Ensembl
rs739060566 48 L>P No Ensembl
rs735592498 116 E>G No Ensembl
rs14256231 117 V>F No Ensembl
rs739052263 145 V>M No Ensembl
rs741240050 193 W>G No Ensembl
rs737778376 194 V>G No Ensembl
rs741425796 249 W>G No Ensembl
rs733116843 373 D>A No Ensembl
rs736837671 381 S>P No Ensembl
rs734738607 392 T>P No Ensembl
rs732648477 393 Q>H No Ensembl

No associated diseases with Q8AWC3

2 regional properties for Q8AWC3

Type Name Position InterPro Accession
domain Peptidase S9, prolyl oligopeptidase, catalytic domain 491 - 702 IPR001375
repeat WD40-like beta propeller 292 - 308 IPR011659

Functions

Description
EC Number
Subcellular Localization
  • Extracellular vesicle membrane ; Lipid-anchor
  • Postsynaptic cell membrane ; Lipid-anchor
  • Synapse
  • Postsynaptic density
  • Early endosome membrane
  • Cell projection, dendrite
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cell cortex
  • Cell projection, dendritic spine
  • Forms virion-like extracellular vesicles that are released from neurons
  • Enriched in postsynaptic density of dendritic spines
  • Accumulates at weaker synapses may be required to prevent their undesired enhancement
  • Associated with the cell cortex of neuronal soma and dendrites
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
early endosome membrane The lipid bilayer surrounding an early endosome.
extracellular vesicle Any vesicle that is part of the extracellular region.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

13 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of AMPA receptor activity Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
regulation of long-term synaptic depression Any process that modulates the frequency, rate or extent of long term synaptic depression.
regulation of long-term synaptic potentiation Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.
regulation of neuronal synaptic plasticity A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
vesicle-mediated intercellular transport A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7LC44 ARC Activity-regulated cytoskeleton-associated protein Homo sapiens (Human) PR
Q9WV31 Arc Activity-regulated cytoskeleton-associated protein Mus musculus (Mouse) PR
Q63053 Arc Activity-regulated cytoskeleton-associated protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MQLDNVTNAG IHSFQGHRGV ANKPNVILQI GKCRAEMLEH VRRTHRHLLS EVSKQVEREL
70 80 90 100 110 120
KGLQKSVGKL ENNLEDHVPT DNQRWKKSIK ACLARCQETI AHLERWVKRE MNVWKEVFFR
130 140 150 160 170 180
LEKWADRLES MGGKYCPGEH GKQTVSVGVG GPEIRPSEGE IYDYALDMSQ MYALTPAPGE
190 200 210 220 230 240
VPSIPQAHDS YQWVSVSEDA PASPVETQIF EDPHEFLSHL EEYLKQVGGT EEYWLSQIQN
250 260 270 280 290 300
HMNGPAKKWW EYKQDSVKNW VEFKKEFLQY SEGTLTRDAI KRELDLPQKE GEPLDQFLWR
310 320 330 340 350 360
KRDLYQTLYV DADEEEIIQY VVGTLQPKLK RFLSYPLPKT LEQLIQRGKE VQGNMDHSEE
370 380 390 400
PSPQRTPEIQ SGDSVESMPP STTASPVPSN GTQPEPPSPP ATVI