AiPD: Autoinhibited Protein Database

Q7LC44

Gene name	ARC
Protein name	Activity-regulated cytoskeleton-associated protein
Names	hArc, Activity-regulated gene 3.1 protein homolog, ARC/ARG3.1, Arg3.1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23237
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-101 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-101 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for Q7LC44

Entry ID	Method	Resolution	Chain	Position	Source
6TN7	X-ray	167 A	B	277-370	PDB
6TNQ	X-ray	130 A	A/C/E	207-277	PDB
6TQ0	X-ray	195 A	A/C/E/G/I/K/M/O	207-277	PDB
6YTU	X-ray	095 A	A/B	99-132	PDB
7R1Z	X-ray	194 A	A	206-361	PDB
7R23	X-ray	277 A	A	206-361	PDB
AF-Q7LC44-F1	Predicted				AlphaFoldDB

305 variants for Q7LC44

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1270568526 CA372384285	4	D>E		No	ClinGen gnomAD
rs1426065219 CA372384266	6	R>W		No	ClinGen gnomAD
rs587734255 CA372384227	8	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs752423065 CA4903020	10	G>R		No	ClinGen ExAC TOPMed gnomAD
rs965493850 CA187425665	11	L>V		No	ClinGen Ensembl
CA372384133 rs1389428507	15	P>L		No	ClinGen TOPMed
rs1249759779 CA372384103	17	P>L		No	ClinGen gnomAD
CA4903018 rs756282396	17	P>S		No	ClinGen ExAC gnomAD
rs1340010362 CA372384101	18	R>G		No	ClinGen gnomAD
rs750662635 CA4903017	18	R>P		No	ClinGen ExAC gnomAD
rs767605928 CA4903016	19	G>C		No	ClinGen ExAC
CA372384085 rs1230875412	19	G>D		No	ClinGen gnomAD
CA372384080 rs1283578932	20	G>R		No	ClinGen gnomAD
CA372384049 rs1587491909	21	Q>L		No	ClinGen Ensembl
rs1587491901 CA372384034	22	V>G		No	ClinGen Ensembl
rs752097434 CA4903014	22	V>M		No	ClinGen ExAC gnomAD
rs1229595790 CA372383979	26	N>S		No	ClinGen gnomAD
CA372383964 rs1295390020	27	V>M		No	ClinGen TOPMed
rs1033218604 CA187425653	28	I>V		No	ClinGen TOPMed
CA372383912 rs1318506929	30	Q>K		No	ClinGen gnomAD
CA4903011 rs775945249	37	E>Q		No	ClinGen ExAC gnomAD
CA372383648 rs1428823666	38	M>I		No	ClinGen gnomAD
CA372383678 rs1468616465	38	M>K		No	ClinGen TOPMed gnomAD
CA372383671 rs1468616465	38	M>T		No	ClinGen TOPMed gnomAD
CA187425633 rs1000029399	39	L>R		No	ClinGen TOPMed
CA187425619 rs1010180504	40	E>*		No	ClinGen Ensembl
CA372383561 rs1177372788	42	V>M		No	ClinGen gnomAD
rs1438316775 CA372383507	44	R>Q		No	ClinGen gnomAD
rs1181187493 CA372383515	44	R>W		No	ClinGen gnomAD
CA372383481 rs1468904354	45	T>M		No	ClinGen TOPMed
rs776211237 CA4903008	47	R>G		No	ClinGen ExAC TOPMed gnomAD
CA372383453 rs776211237	47	R>W		No	ClinGen ExAC TOPMed gnomAD
CA4903007 rs138879893	49	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4903004 rs771957879	53	V>M		No	ClinGen ExAC gnomAD
rs1278372103 CA372383336	54	S>F		No	ClinGen gnomAD
rs1239211385 CA372383291	56	Q>P		No	ClinGen gnomAD
CA4903003 rs748107047	57	V>M		No	ClinGen ExAC gnomAD
CA372383253 rs1416639608	58	E>G		No	ClinGen TOPMed
rs1451137469 CA372383229 COSM3698861	59	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA4903001 rs754809780	65	H>L		No	ClinGen ExAC gnomAD
rs371846206 CA187425564	65	H>Q		No	ClinGen ExAC gnomAD
rs1470579436 CA372383095	66	R>Q		No	ClinGen TOPMed gnomAD
CA4902999 rs757517795	66	R>W		No	ClinGen ExAC gnomAD
COSM1183323 CA372383071 rs1587491773	68	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1181633544 CA372383045	69	G>A		No	ClinGen gnomAD
CA372383032 rs1443955798	70	K>T		No	ClinGen gnomAD
CA4902997 rs751531647	72	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1283180139 CA372382936	74	N>D		No	ClinGen gnomAD
rs145645912 CA4902995	77	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA372382871 rs764286977	77	G>R		No	ClinGen ExAC gnomAD
CA4902996 rs764286977	77	G>S		No	ClinGen ExAC gnomAD
CA372382833 rs1563776832	78	Y>F		No	ClinGen Ensembl
CA372382857 rs1355135629	78	Y>H		No	ClinGen TOPMed
CA4902993 rs765690457	79	V>E		No	ClinGen ExAC TOPMed gnomAD
rs753294130 CA4902994	79	V>M		No	ClinGen ExAC gnomAD
CA4902992 rs759874303	81	T>M		No	ClinGen ExAC gnomAD
CA372382750 rs1454966876	82	S>R		No	ClinGen gnomAD
CA4902991 rs777065602	84	S>L		No	ClinGen ExAC gnomAD
rs1401531397 CA372382672	85	Q>H		No	ClinGen gnomAD
rs1387167859 CA372382661	86	R>C		No	ClinGen gnomAD
CA372382646 rs1335513085	87	W>G		No	ClinGen TOPMed
rs770423305 CA4902990	89	K>M		No	ClinGen ExAC TOPMed gnomAD
CA372382592 rs770423305	89	K>T		No	ClinGen ExAC TOPMed gnomAD
rs937053011 CA187425509	90	S>F		No	ClinGen TOPMed gnomAD
CA372382562 rs1186822315	91	I>V		No	ClinGen TOPMed
rs1474326952 CA372382513	93	A>T		No	ClinGen gnomAD
CA372382493 rs1474056546	94	C>R		No	ClinGen TOPMed
rs1193395488 CA372382416	97	R>C		No	ClinGen gnomAD
CA372382412 rs1218485440	97	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1218485440 CA372382406	97	R>L		No	ClinGen TOPMed
rs778496793 CA187425508	98	C>S		No	ClinGen Ensembl
CA372382266 rs771620864	103	A>S		No	ClinGen ExAC gnomAD
CA4902987 rs771620864	103	A>T	Variant assessed as Somatic; 5.501e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA372382218 rs1359337112	106	E>K		No	ClinGen gnomAD
CA372382181 rs587756427	107	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA187425491 rs587756427	107	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA372382171 rs1248577625	107	R>H		No	ClinGen gnomAD
CA4902986 rs587756427	107	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA372382149 rs1360259714	108	W>*		No	ClinGen gnomAD
rs1269999644 CA372381243	110	K>*		No	ClinGen gnomAD
TCGA novel	110	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1343876488 CA372381228	111	R>C		No	ClinGen TOPMed
CA4902985 COSM1455264 rs774341447	111	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA372381223 rs774341447	111	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4902984 rs199521561	113	M>I		No	ClinGen ExAC gnomAD
rs1301368690 CA372381201	113	M>K		No	ClinGen gnomAD
rs369013371 CA187425471	116	W>C		No	ClinGen ESP TOPMed gnomAD
CA372381117 rs1295306970	120	F>V		No	ClinGen TOPMed
rs1356202934 CA372381094	121	Y>C		No	ClinGen TOPMed
COSM1489064 CA372381048 rs1266406700	125	R>C	Variant assessed as Somatic; 7.967e-05 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1198036851 CA372381044	125	R>L		No	ClinGen TOPMed gnomAD
CA372381015 rs1270448410	128	D>N		No	ClinGen gnomAD
CA372380978 rs1279407742	133	T>R		No	ClinGen TOPMed
CA187425425 rs1036190729	135	G>S		No	ClinGen TOPMed gnomAD
CA372380961 rs1215593201	136	K>R		No	ClinGen gnomAD
CA372380952 rs1469183116	137	Y>C		No	ClinGen TOPMed
rs758614505 CA4902978	141	S>C		No	ClinGen ExAC TOPMed gnomAD
rs758614505 CA372380930	141	S>G		No	ClinGen ExAC TOPMed gnomAD
CA372380918 rs1223166061	142	E>D		No	ClinGen gnomAD
rs753240952 CA4902977	143	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1305047419 CA372380910	144	A>P		No	ClinGen TOPMed gnomAD
CA372380909 rs1305047419	144	A>S		No	ClinGen TOPMed gnomAD
CA372380904 rs867095273	145	R>C		No	ClinGen gnomAD
CA372380900 rs1563776753	145	R>L		No	ClinGen Ensembl
rs1563776753 CA372380901	145	R>P		No	ClinGen Ensembl
CA187425384 rs867095273	145	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1563776747 CA372380896	146	H>R		No	ClinGen Ensembl
rs765780465 CA4902976	146	H>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	147	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs931618958 CA372380885	148	V>F		No	ClinGen gnomAD
CA187425378 rs931618958	148	V>I		No	ClinGen gnomAD
CA187425355 rs922561519	150	V>M		No	ClinGen TOPMed gnomAD
rs1174978220 CA372380858	153	G>W		No	ClinGen gnomAD
rs766788440 CA372380849	154	G>D		No	ClinGen ExAC TOPMed gnomAD
rs766788440 CA4902973	154	G>V		No	ClinGen ExAC TOPMed gnomAD
CA372380844 rs1563776740	155	P>R		No	ClinGen Ensembl
rs1375598780 CA372380835	156	E>D		No	ClinGen TOPMed
rs1240842464 CA372380829	157	S>N		No	ClinGen TOPMed
CA4902970 rs767012127	158	Y>H		No	ClinGen ExAC gnomAD
CA372380794 rs1223072865	161	E>D		No	ClinGen TOPMed gnomAD
CA4902969 rs761373281	161	E>K		No	ClinGen ExAC gnomAD
rs1303498205 CA372380791	162	A>E		No	ClinGen gnomAD
rs773867649 CA4902968	162	A>T		No	ClinGen ExAC gnomAD
rs2234911 CA372380782	163	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1372504701 CA372380788	163	D>N		No	ClinGen gnomAD
CA4902967 rs768517487	163	D>V		No	ClinGen ExAC gnomAD
rs1403566740 CA372380779	164	G>C		No	ClinGen gnomAD
rs1436919893 CA372380778	164	G>D		No	ClinGen TOPMed
rs769666928 CA4902965	165	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4902963 rs747190210	166	D>G		No	ClinGen ExAC
CA372380768 rs1201978742	166	D>N		No	ClinGen TOPMed
rs1469934532 CA372380757	167	Y>S		No	ClinGen gnomAD
rs868521724 CA187425233	168	T>I		No	ClinGen Ensembl
rs587657838 CA187425251	168	T>P		No	ClinGen 1000Genomes
CA4902960 rs748171375	169	V>I		No	ClinGen ExAC gnomAD
rs1178233108 CA372380720	173	A>S		No	ClinGen TOPMed gnomAD
CA372380722 rs1178233108	173	A>T		No	ClinGen TOPMed gnomAD
CA372380717 rs1436849056	173	A>V		No	ClinGen gnomAD
CA372380707 rs1442100907	175	T>N		No	ClinGen gnomAD
rs865823047 CA187425185	175	T>P		No	ClinGen Ensembl
rs779165064 CA4902959	176	P>L		No	ClinGen ExAC gnomAD
CA4902958 rs755391698	177	P>S		No	ClinGen ExAC gnomAD
rs766622368 CA4902957	178	P>A		No	ClinGen ExAC gnomAD
rs766622368 CA4902956	178	P>S		No	ClinGen ExAC gnomAD
TCGA novel	179	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1262375538 CA372380683	180	A>P		No	ClinGen TOPMed gnomAD
CA372380684 rs1262375538	180	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA372380678 rs1316368950	181	G>S		No	ClinGen gnomAD
CA4902952 rs761462672	182	E>K		No	ClinGen ExAC TOPMed gnomAD
rs199735061 CA4902948	185	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1286798419 CA372380630	188	P>H		No	ClinGen TOPMed gnomAD
rs1286798419 CA372380628	188	P>L		No	ClinGen TOPMed gnomAD
CA372380627 rs1345207161	189	A>T		No	ClinGen gnomAD
TCGA novel	190	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372380621 rs1160664504	190	E>K		No	ClinGen gnomAD
CA187425149 rs969355649	194	Y>C		No	ClinGen Ensembl
CA372380582 rs1422057886	195	Q>*		No	ClinGen gnomAD
rs199916173 CA372380564	196	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199916173 CA4902946	196	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA372380569 rs1383993121	196	P>S		No	ClinGen gnomAD
rs1258733125 CA372380547	197	W>C		No	ClinGen gnomAD
TCGA novel	200	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1485671243 CA372380518	200	G>D		No	ClinGen gnomAD
CA4902945 rs776582573	200	G>S		No	ClinGen ExAC TOPMed gnomAD
CA4902944 rs140481166	202	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA372380482 CA187425133 rs372418087	203	G>R		No	ClinGen ESP TOPMed gnomAD
rs748412721 CA4902943	204	Q>E		No	ClinGen ExAC
rs1250593894 CA372380465	204	Q>H		No	ClinGen TOPMed
CA4902942 rs768828786	204	Q>L		No	ClinGen ExAC gnomAD
CA4902941 rs768828786	204	Q>R		No	ClinGen ExAC gnomAD
CA372380448 rs1291008401	205	P>L		No	ClinGen gnomAD
CA187425119 rs749743916	207	P>A		No	ClinGen ExAC TOPMed gnomAD
CA4902940 rs749743916	207	P>S		No	ClinGen ExAC TOPMed gnomAD
CA372380406 rs1336602149	209	V>L		No	ClinGen TOPMed gnomAD
CA4902937 rs750725106	210	D>N		No	ClinGen ExAC gnomAD
CA4902936 rs781555606	212	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA372380323 rs1421830302	215	E>*		No	ClinGen TOPMed
rs751266915 CA4902934	217	P>S		No	ClinGen ExAC gnomAD
rs763502872 CA4902933	218	R>Q		No	ClinGen ExAC gnomAD
CA372380218 rs1370501987	223	H>Y		No	ClinGen gnomAD
TCGA novel	224	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM205523 rs368167896 CA372380142	229	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA4902930 rs201562490	231	V>G		No	ClinGen ExAC gnomAD
CA372380118 rs1392343612	231	V>M		No	ClinGen TOPMed
TCGA novel	232	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1324081004 CA372380091	233	G>C		No	ClinGen TOPMed
TCGA novel	239	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4902926 rs201238711	240	S>A		No	ClinGen ExAC
rs74348901 CA187425012	240	S>C		No	ClinGen Ensembl
TCGA novel	240	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4902925 rs774691009	241	Q>K		No	ClinGen ExAC gnomAD
CA372379981 rs1489426720	241	Q>R		No	ClinGen gnomAD
CA372379928 rs1428311753	245	H>Y		No	ClinGen TOPMed
CA187425006 rs112306578	248	G>E		No	ClinGen gnomAD
rs1361680452 CA372379883	248	G>R		No	ClinGen gnomAD
CA372379670 rs1221342648	261	V>L		No	ClinGen gnomAD
rs1221342648 CA372379674	261	V>M		No	ClinGen gnomAD
CA372379640 rs1344266287	262	K>N		No	ClinGen gnomAD
CA4902920 rs746402173	263	N>D		No	ClinGen ExAC gnomAD
TCGA novel	267	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781518844 CA4902919	272	L>R		No	ClinGen ExAC TOPMed gnomAD
CA4902915 rs758002181	276	E>D		No	ClinGen ExAC gnomAD
rs751211937 CA4902917	276	E>K		No	ClinGen ExAC gnomAD
rs1479586907 CA372379387	277	G>D		No	ClinGen gnomAD
rs370545261 CA4902914	277	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1563776587 CA372379372	278	T>M		No	ClinGen Ensembl
CA372379309 rs1191566837	284	I>N		No	ClinGen TOPMed
CA372379286 rs988806388	286	R>G		No	ClinGen gnomAD
rs1480815830 CA372379283	286	R>H		No	ClinGen gnomAD
rs988806388 COSM1096848 CA187424934	286	R>S	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1201319514 CA372379269	287	E>G		No	ClinGen gnomAD
CA4902908 rs772885468	289	D>A		No	ClinGen ExAC gnomAD
CA4902909 rs760612016	289	D>N		No	ClinGen ExAC TOPMed gnomAD
rs763103743 CA4902906	291	P>L		No	ClinGen ExAC gnomAD
TCGA novel	291	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372379186 rs1468425944	294	Q>E		No	ClinGen gnomAD
rs746365444 CA4902903	294	Q>R		No	ClinGen ExAC gnomAD
CA372379138 rs1587491153	297	P>L		No	ClinGen Ensembl
CA372379147 rs1479069599	297	P>T		No	ClinGen gnomAD
CA372379125 rs1180933281	299	D>N		No	ClinGen gnomAD
TCGA novel	301	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	303	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758031109 CA4902898	304	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA372379057 rs587767434	304	R>H		No	ClinGen 1000Genomes gnomAD
CA187424796 rs587767434	304	R>L		No	ClinGen 1000Genomes gnomAD
rs1320110923 CA372379044	305	K>R		No	ClinGen TOPMed
CA372379036 rs1460591873	306	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	307	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	310	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372378932 rs1171388183	314	V>A		No	ClinGen Ensembl
rs753822447 CA4902895	314	V>L		No	ClinGen ExAC TOPMed gnomAD
rs753822447 CA4902894	314	V>M		No	ClinGen ExAC TOPMed gnomAD
rs587711195 CA372378911	315	D>E		No	ClinGen 1000Genomes TOPMed gnomAD
rs756131769 CA4902892	316	A>S		No	ClinGen ExAC gnomAD
CA4902890 rs767244388	317	D>G		No	ClinGen ExAC gnomAD
rs887722830 CA187424744	318	E>K		No	ClinGen Ensembl
rs763198702 CA372378738	324	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA372378713 rs1203872774	326	V>L		No	ClinGen TOPMed
rs1563776532 CA372378690	327	G>D		No	ClinGen Ensembl
rs1288649487 CA372378619	331	P>L		No	ClinGen TOPMed
CA372378632 rs1382268510	331	P>T		No	ClinGen gnomAD
rs775636351 CA372378588	333	L>F		No	ClinGen ExAC TOPMed gnomAD
rs775636351 CA4902888	333	L>V		No	ClinGen ExAC TOPMed gnomAD
CA4902886 rs759548098	335	R>C		No	ClinGen ExAC gnomAD
CA187424728 rs776707820	335	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4902885 rs776707820	335	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4902887 rs759548098	335	R>S		No	ClinGen ExAC gnomAD
rs202009326 COSM50582 CA4902882	338	R>C	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA4902881 rs754781408	338	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs202009326 CA372378494	338	R>S		No	ClinGen ExAC TOPMed gnomAD
rs747822194 CA4902880	339	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	340	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	341	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748747847 CA4902877	343	K>R		No	ClinGen ExAC gnomAD
rs926055055 CA187424702	348	L>F		No	ClinGen TOPMed gnomAD
TCGA novel	348	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372378329 rs1452919121	349	I>N		No	ClinGen Ensembl
rs776073711 CA4902874	353	M>T		No	ClinGen ExAC gnomAD
rs1359107496 CA372378256	353	M>V		No	ClinGen TOPMed gnomAD
rs1040102351 CA187424689	354	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA372378186 rs1450390676	356	Q>*		No	ClinGen gnomAD
CA372378172 rs1310712023	357	D>Y		No	ClinGen TOPMed
TCGA novel	360	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372378014 rs1396235029	363	A>V		No	ClinGen TOPMed
COSM2867622 CA4902869 rs759778933	364	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4902868 rs753876529	365	P>A		No	ClinGen ExAC gnomAD
CA4902867 rs373236073	365	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA187424652 rs373236073	365	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772479980 CA4902864	367	G>D		No	ClinGen ExAC TOPMed gnomAD
CA372377955 rs1439783366	367	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4902863 rs762016127	369	H>R		No	ClinGen ExAC gnomAD
rs1488960239 CA372377883	371	P>L		No	ClinGen gnomAD
CA4902859 rs779675780	372	V>A		No	ClinGen ExAC gnomAD
CA4902860 rs376687795	372	V>L		No	ClinGen ESP ExAC gnomAD
rs376687795 CA187424627	372	V>M		No	ClinGen ESP ExAC gnomAD
CA4902858 rs769231970	373	E>K		No	ClinGen ExAC gnomAD
rs372892204 CA4902857	374	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4902856 rs780927796	376	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1466266396 CA372377786	379	L>F		No	ClinGen TOPMed
rs371921712 CA372377780	380	T>K		No	ClinGen TOPMed gnomAD
rs371921712 CA187424595	380	T>M		No	ClinGen TOPMed gnomAD
rs371921712 CA372377778	380	T>R		No	ClinGen TOPMed gnomAD
CA4902854 rs375709912	380	T>S		No	ClinGen ESP ExAC gnomAD
rs777576732 CA4902853	381	P>R		No	ClinGen ExAC gnomAD
CA4902850 rs766434970	382	A>P		No	ClinGen ExAC TOPMed gnomAD
rs766434970 CA372377762	382	A>S		No	ClinGen ExAC TOPMed gnomAD
rs766434970 CA4902851	382	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4902849 rs760732074	382	A>V		No	ClinGen ExAC TOPMed gnomAD
rs750521419 CA4902848	383	P>A		No	ClinGen ExAC TOPMed gnomAD
CA4902846 rs1478604335	384	N>D		No	ClinGen gnomAD
rs1426502315 CA372377736	384	N>K		No	ClinGen gnomAD
CA372377728 rs1198142862	385	S>N		No	ClinGen gnomAD
CA372377706 rs1224200466	386	E>D		No	ClinGen gnomAD
CA372377716 rs1247856381	386	E>K		No	ClinGen gnomAD
CA4902843 rs774812713	388	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA372377679 rs1320277133	389	A>P		No	ClinGen TOPMed gnomAD
CA372377680 rs1320277133	389	A>T		No	ClinGen TOPMed gnomAD
rs775336464 CA372377636	392	R>P		No	ClinGen ExAC gnomAD
rs775336464 CA4902840	392	R>Q		No	ClinGen ExAC gnomAD
CA4902841 COSM4006857 rs762668132	392	R>W	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA372377612 rs1276499964	394	Q>R		No	ClinGen gnomAD
CA4902839 rs769495014	395	P>L		No	ClinGen ExAC gnomAD
CA187424556 rs917971005	395	P>T		No	ClinGen gnomAD
rs1466856033 CA372377595	396	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA187424544 rs111386954	397	E>K		No	ClinGen Ensembl

No associated diseases with Q7LC44

1 regional properties for Q7LC44

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	85 - 544	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Extracellular vesicle membrane ; Lipid-anchor Postsynaptic cell membrane ; Lipid-anchor Synapse Postsynaptic density Early endosome membrane Cell projection, dendrite Cytoplasm, cytoskeleton Cytoplasm, cell cortex Cell projection, dendritic spine Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasmic vesicle, clathrin-coated vesicle membrane	Forms virion-like extracellular vesicles that are released from neurons Enriched in postsynaptic density of dendritic spines Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state Accumulation at weaker synapses may be required to prevent their undesired enhancement Associated with the cell cortex of neuronal soma and dendrites (By similarity) Associated with the sperm tail (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

16 GO annotations of cellular component

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
early endosome membrane	The lipid bilayer surrounding an early endosome.
extracellular vesicle	Any vesicle that is part of the extracellular region.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
neuronal ribonucleoprotein granule	A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density membrane	The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
postsynaptic endosome	An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse.

1 GO annotations of molecular function

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

20 GO annotations of biological process

Name	Definition
anterior/posterior pattern specification	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
dendritic spine morphogenesis	The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
endoderm development	The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
learning	Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
long-term memory	The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
long-term synaptic potentiation	A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
modulation of chemical synaptic transmission	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of AMPA receptor activity	Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of cell morphogenesis	Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
regulation of dendritic spine morphogenesis	Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
regulation of long-term synaptic depression	Any process that modulates the frequency, rate or extent of long term synaptic depression.
regulation of long-term synaptic potentiation	Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.
regulation of neuronal synaptic plasticity	A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
regulation of postsynaptic neurotransmitter receptor internalization	Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
vesicle-mediated intercellular transport	A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8AWC3	ARC	Activity-regulated cytoskeleton-associated protein	Gallus gallus (Chicken)	PR
Q9WV31	Arc	Activity-regulated cytoskeleton-associated protein	Mus musculus (Mouse)	PR
Q63053	Arc	Activity-regulated cytoskeleton-associated protein	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MELDHRTSGG	LHAYPGPRGG	QVAKPNVILQ	IGKCRAEMLE	HVRRTHRHLL	AEVSKQVERE
70	80	90	100	110	120
LKGLHRSVGK	LESNLDGYVP	TSDSQRWKKS	IKACLCRCQE	TIANLERWVK	REMHVWREVF
130	140	150	160	170	180
YRLERWADRL	ESTGGKYPVG	SESARHTVSV	GVGGPESYCH	EADGYDYTVS	PYAITPPPAA
190	200	210	220	230	240
GELPGQEPAE	AQQYQPWVPG	EDGQPSPGVD	TQIFEDPREF	LSHLEEYLRQ	VGGSEEYWLS
250	260	270	280	290	300
QIQNHMNGPA	KKWWEFKQGS	VKNWVEFKKE	FLQYSEGTLS	REAIQRELDL	PQKQGEPLDQ
310	320	330	340	350	360
FLWRKRDLYQ	TLYVDADEEE	IIQYVVGTLQ	PKLKRFLRHP	LPKTLEQLIQ	RGMEVQDDLE
370	380	390
QAAEPAGPHL	PVEDEAETLT	PAPNSESVAS	DRTQPE