AiPD: Autoinhibited Protein Database

Q86WV1

Gene name	SKAP1 (SCAP1, SKAP55)
Protein name	Src kinase-associated phosphoprotein 1
Names	Src family-associated phosphoprotein 1, Src kinase-associated phosphoprotein of 55 kDa, SKAP-55, pp55
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8631
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

227-307 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

227-307 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q86WV1

Entry ID	Method	Resolution	Chain	Position	Source
1U5D	X-ray	170 A	A/B/C/D	108-213	PDB
AF-Q86WV1-F1	Predicted				AlphaFoldDB

281 variants for Q86WV1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA400316228 rs1351608116	2	Q>R		No	ClinGen gnomAD
rs1259877653 CA400316224	3	A>T		No	ClinGen gnomAD
rs751222794 CA8631623	4	A>T		No	ClinGen ExAC gnomAD
rs1236892796 CA400316196	7	P>L		No	ClinGen gnomAD
CA8631621 rs762740429	9	E>K		No	ClinGen ExAC gnomAD
CA400316173 rs1350430741	11	R>G		No	ClinGen gnomAD
CA400316169 rs1387810311	11	R>P		No	ClinGen TOPMed
CA400316166 rs1448578017	12	W>R		No	ClinGen TOPMed
rs148514032 CA8631612	17	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA400314061 rs1356696565	18	E>K		No	ClinGen gnomAD
rs1026271488 CA291164971	21	L>V		No	ClinGen gnomAD
rs1236319510 CA400314027	23	E>K		No	ClinGen gnomAD
CA8631611 rs748506982	24	G>D		No	ClinGen ExAC
CA8631607 rs201863491	26	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8631609 rs11079820	26	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1322618930 CA400314003	27	N>D		No	ClinGen TOPMed
rs1017344726 CA400313997	27	N>K		No	ClinGen TOPMed
TCGA novel	30	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1226061277 CA400313973	31	S>G		No	ClinGen TOPMed
CA8631606 rs550600837	31	S>T		No	ClinGen 1000Genomes ExAC gnomAD
CA291164963 rs939886164	32	A>T		No	ClinGen TOPMed gnomAD
CA8631604 rs746503212	32	A>V		No	ClinGen ExAC gnomAD
rs777440307 CA8631603	33	V>A		No	ClinGen ExAC gnomAD
CA8631602 rs758006067	34	A>E		No	ClinGen ExAC gnomAD
rs1229847951 CA400313958	34	A>T		No	ClinGen TOPMed
rs1453786574 CA400313916	39	D>E		No	ClinGen gnomAD
rs753812443 CA8631598	40	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA291164957 rs1051329325	41	I>F		No	ClinGen TOPMed gnomAD
TCGA novel	41	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs112999194 CA8631597	43	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA8631596 rs112999194	43	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA291164955 rs116549994	43	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
CA8631595 rs773197690	46	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs146257434 CA291164952	47	Q>E		No	ClinGen ESP TOPMed gnomAD
CA8631594 CA8631593 rs761919700	47	Q>H		No	ClinGen ExAC gnomAD
rs1309287514 CA400313857	49	K>R		No	ClinGen gnomAD
CA8631592 rs373333526	50	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1232920630 CA400313853	50	A>S		No	ClinGen TOPMed gnomAD
CA291158927 rs990867731	52	Y>C		No	ClinGen TOPMed
rs756028307 CA8631576	52	Y>N		No	ClinGen ExAC gnomAD
rs372268674 CA8631574	53	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA291158921 rs887085975	54	W>L		No	ClinGen Ensembl
CA400313122 rs1567884117	55	D>Y		No	ClinGen Ensembl
rs866208824 CA291158918	57	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8631573 rs368159992	58	P>A		No	ClinGen ExAC gnomAD
rs1414269659 CA400313098	58	P>L		No	ClinGen gnomAD
rs368159992 CA8631572	58	P>T		No	ClinGen ExAC gnomAD
rs764249578	60	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA400312459 rs751645756	60	G>A		No	ClinGen ExAC TOPMed gnomAD
CA291154528 rs751645756	60	G>E		No	ClinGen ExAC TOPMed gnomAD
CA8631551 rs751645756	60	G>V		No	ClinGen ExAC TOPMed gnomAD
rs866976111 CA291154517	61	G>*		No	ClinGen gnomAD
TCGA novel	62	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs114223532 CA400312441	63	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs114223532 CA8631548	63	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8631547 rs765511266	65	Q>*		No	ClinGen ExAC gnomAD
CA8631546 rs376131521	65	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1459376316 CA400312421	66	D>E		No	ClinGen gnomAD
rs1598596432 CA400312427	66	D>N		No	ClinGen Ensembl
rs373452898 CA291154477	68	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs373452898 CA8631545	68	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA400312400 rs771472546	69	D>E		No	ClinGen ExAC TOPMed gnomAD
CA400312405 rs1244505324	69	D>N		No	ClinGen gnomAD
TCGA novel	69	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761364739 CA400312393 CA8631543	70	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1315078152 CA400312394	70	D>V		No	ClinGen gnomAD
TCGA novel	73	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774021193 CA8631542	73	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8631538 rs769466816	74	G>E		No	ClinGen ExAC TOPMed gnomAD
CA8631540 COSM1734574 CA8631539 rs116419751	74	G>R	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	79	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757237792 CA8631535	82	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs377081667 CA8631533	83	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758537059 CA8631532	84	A>T		No	ClinGen ExAC gnomAD
CA400312309 rs1438004436	84	A>V		No	ClinGen gnomAD
rs1286782749 CA400312282	88	S>L		No	ClinGen TOPMed
CA400312257 rs1209664574 COSM1172426	92	D>N	oesophagus skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs141667170 CA8631530	93	E>K		No	ClinGen ESP ExAC gnomAD
rs759751117 CA8631529	94	G>*		No	ClinGen ExAC gnomAD
rs376880992 CA8631518	95	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1290777525 CA400313826	95	M>V		No	ClinGen TOPMed
CA8631517 rs746940081	96	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1379875054 CA400313805	97	D>E		No	ClinGen gnomAD
CA8631516 rs777742001	97	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1224901446 CA400313811	97	D>N		No	ClinGen gnomAD
CA291055927 rs1036659799	98	I>V		No	ClinGen Ensembl
rs748263980 CA8631514	99	V>I		No	ClinGen ExAC gnomAD
rs748263980 CA291055924	99	V>L		No	ClinGen ExAC gnomAD
CA400313769 rs1261334043	103	Q>L		No	ClinGen gnomAD
rs1567812577 CA400313763	104	E>G		No	ClinGen Ensembl
CA8631513 rs778961593	104	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	105	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8631511 rs754058141	108	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8631510 rs766735166	112	G>R		No	ClinGen ExAC
rs932858939 CA291055923	113	Y>C		No	ClinGen Ensembl
rs1365187909 CA400313666	118	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs750956834 CA8631508	118	S>N		No	ClinGen ExAC gnomAD
rs1256487188 CA400313654	119	K>R		No	ClinGen gnomAD
rs768155813 CA8631507	120	D>Y		No	ClinGen ExAC gnomAD
rs370712801 CA8631492	123	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
TCGA novel	124	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368601769 CA8631490 COSM1563789	126	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA400313593 rs1199032711	126	S>P		No	ClinGen gnomAD
TCGA novel	127	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200982650 CA291055743	129	Q>K		No	ClinGen 1000Genomes
COSM1610417 rs752043819 CA8631487	131	R>*	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA400313556 rs1482971217	131	R>Q		No	ClinGen TOPMed
CA291055741 rs375916385	135	V>F		No	ClinGen ESP TOPMed gnomAD
rs1333870902 CA400313522	136	S>N		No	ClinGen gnomAD
rs759021727 CA8631485 COSM223886	138	G>D	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	140	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766023837 CA400313485 CA8631483	141	Y>*		No	ClinGen ExAC gnomAD
rs371478605 CA8631482	143	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8631481 rs773010910	144	A>S		No	ClinGen ExAC gnomAD
rs984596720 CA291055439	149	K>R		No	ClinGen Ensembl
rs765964736 CA8631466	153	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1454098344 CA400313385	154	T>A		No	ClinGen TOPMed
rs750117051 CA8631465	157	I>L		No	ClinGen ExAC gnomAD
rs767297976 CA8631463	157	I>M		No	ClinGen ExAC gnomAD
rs750117051 CA8631464	157	I>V		No	ClinGen ExAC gnomAD
rs761570642 CA8631462	158	K>N		No	ClinGen ExAC gnomAD
rs774288550 CA8631461	159	G>S		No	ClinGen ExAC gnomAD
CA400313342 rs2278868	161	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2278868 VAR_029811 CA8631458	161	G>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	161	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400313330 rs1273505806	163	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs573034197 CA8631456 COSM1130244	163	R>W	pancreas large_intestine prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA400313325 rs1409839486	164	M>V		No	ClinGen TOPMed gnomAD
rs1439010314 CA400313314	165	A>G		No	ClinGen gnomAD
CA400313310 rs1398260208	166	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8631455 rs770050644	166	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771265934 CA8631452	167	H>N		No	ClinGen ExAC TOPMed gnomAD
rs771265934 CA8631453	167	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA291055438 rs199779652	168	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs199779652 CA8631451	168	L>R		No	ClinGen ExAC TOPMed gnomAD
CA8631449 rs758850569	169	R>*		No	ClinGen ExAC gnomAD
rs138939780 CA8631448 COSM233371	169	R>Q	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA8631447 rs779507054	171	D>E		No	ClinGen ExAC gnomAD
CA8631446 rs755689431	172	S>F		No	ClinGen ExAC TOPMed gnomAD
CA400313255 rs1598405298	175	E>D		No	ClinGen Ensembl
rs868270032 CA291055437	175	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	178	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA291055436 rs1004261231	178	F>S		No	ClinGen TOPMed
rs1468961174 CA400313231	179	E>Q		No	ClinGen TOPMed
CA400313223 rs1488989398	180	L>V		No	ClinGen TOPMed gnomAD
rs750065617 CA8631445	181	T>N		No	ClinGen ExAC gnomAD
CA400313209 rs1208809418	182	S>F		No	ClinGen gnomAD
CA8631444 rs767091028	183	Q>*		No	ClinGen ExAC gnomAD
rs1277090542 CA400313205	183	Q>R		No	ClinGen gnomAD
rs1017266798 CA291055435	186	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8631443 rs761604918 COSM3795726	186	R>H	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	187	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400313167 rs1260084715	188	Y>*		No	ClinGen gnomAD
CA400313162 rs1289590687	189	E>G		No	ClinGen gnomAD
CA8631428 rs745387774	190	F>L		No	ClinGen ExAC gnomAD
rs780860622 CA8631427	195	P>A		No	ClinGen ExAC gnomAD
rs1466969226 CA400313038	195	P>L		No	ClinGen gnomAD
rs939630563 CA291055130	196	A>G		No	ClinGen TOPMed
rs944254274 CA291055128	199	R>G		No	ClinGen Ensembl
CA8631425 rs751278029	205	I>V		No	ClinGen ExAC gnomAD
rs1567809293 CA400312964	206	S>N		No	ClinGen Ensembl
CA8631424 rs146842117	206	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1598403164 CA400312960	207	F>I		No	ClinGen Ensembl
CA8631423 rs758322592	207	F>S		No	ClinGen ExAC gnomAD
TCGA novel	208	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142516955 CA400312933	210	K>N		No	ClinGen ESP ExAC gnomAD
rs756836327 CA8631409	212	L>R		No	ClinGen ExAC gnomAD
rs1448215053 CA400312902	213	S>R		No	ClinGen TOPMed
rs367654574 CA291054830	215	L>V		No	ClinGen Ensembl
rs1370565104 CA400312883	216	T>N		No	ClinGen TOPMed
rs1222641715 CA400312882	217	I>L		No	ClinGen TOPMed
rs746625539 CA8631408	218	P>L		No	ClinGen ExAC gnomAD
CA400312873 rs1380251270	218	P>S		No	ClinGen TOPMed gnomAD
rs1325320595 CA400312867	219	Y>C		No	ClinGen TOPMed
rs758197913 CA8631406	222	D>V		No	ClinGen ExAC TOPMed gnomAD
CA400312825 rs1190968672	224	E>D		No	ClinGen gnomAD
CA400312831 rs1200479471	224	E>K		No	ClinGen TOPMed
rs764622914 CA291054825	225	E>G		No	ClinGen Ensembl
CA291054826 rs868776600	225	E>K		No	ClinGen gnomAD
rs1598401354 CA400312817	226	E>K		No	ClinGen Ensembl
rs759135604 CA8631405	227	E>K		No	ClinGen ExAC TOPMed gnomAD
CA291054823 rs866205509	228	K>E		No	ClinGen Ensembl
rs1271285621 CA400312799	228	K>R		No	ClinGen gnomAD
rs1223348241 CA400312781	230	E>D		No	ClinGen TOPMed gnomAD
CA400312778 rs1598401310	231	T>A		No	ClinGen Ensembl
rs1567808466 CA400312748	235	I>V		No	ClinGen Ensembl
rs1241024008 CA400312736	236	D>E		No	ClinGen gnomAD
rs1176633176 CA400312738	236	D>G		No	ClinGen TOPMed
rs1283801825 CA400312742	236	D>Y		No	ClinGen gnomAD
CA400312731 rs1481579875	237	G>D		No	ClinGen TOPMed
CA400312734 rs1317431256	237	G>S		No	ClinGen TOPMed gnomAD
CA291054818 rs955198177	240	S>A		No	ClinGen TOPMed
rs1466420501 CA400312709	240	S>C		No	ClinGen TOPMed
rs765216777 CA8631404	241	P>S		No	ClinGen ExAC gnomAD
CA8631403 VAR_035343 rs35288886	242	S>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs111771569 CA8631402	246	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1442103475 CA400312665	247	C>Y		No	ClinGen TOPMed
CA400312660 rs1158464855	248	R>G		No	ClinGen gnomAD
CA400312656 CA400312655 rs1358000603	248	R>S		No	ClinGen gnomAD
CA8631400 rs760867806	248	R>T		No	ClinGen ExAC gnomAD
rs750553383 CA8631399	250	T>I		No	ClinGen ExAC TOPMed gnomAD
CA400312648 rs1296907727	250	T>P		No	ClinGen gnomAD
rs767733529 CA8631398	253	P>R		No	ClinGen ExAC gnomAD
CA8631397 rs762127748	254	G>E		No	ClinGen ExAC gnomAD
CA8631396 rs774723073	255	S>N		No	ClinGen ExAC gnomAD
CA8631395 rs769061048	257	G>E		No	ClinGen ExAC TOPMed gnomAD
CA400312586 rs1318375593	260	E>K		No	ClinGen TOPMed
rs776134630 CA8631393	261	P>L		No	ClinGen ExAC gnomAD
rs763341737 CA8631394	261	P>S		No	ClinGen ExAC gnomAD
rs770286423 CA8631391	267	E>G		No	ClinGen ExAC gnomAD
rs771871459 CA8631388	269	D>V		No	ClinGen ExAC gnomAD
CA400312511 rs1337949712	270	I>S		No	ClinGen TOPMed gnomAD
rs1337949712 CA400312510	270	I>T		No	ClinGen TOPMed gnomAD
CA8631386 rs747850299	271	Y>C		No	ClinGen ExAC gnomAD
CA400312481 rs1033101502 CA291054794	274	L>F		No	ClinGen TOPMed
CA8631384 rs754886738	275	P>R		No	ClinGen ExAC gnomAD
rs1490853547 CA400312475	276	D>N		No	ClinGen TOPMed
CA8631366 rs151249688	278	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8631367 rs151249688	278	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8631365 rs768514743	279	H>R		No	ClinGen ExAC gnomAD
CA8631362 rs573126940	285	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs574969815 CA291053575	286	S>G		No	ClinGen gnomAD
rs781219641 CA8631360	289	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8631359 COSM561220 rs142272724	290	R>*	lung Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA8631358 rs751770631 COSM1722680	290	R>Q	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8631335 rs765629624	293	V>A		No	ClinGen ExAC gnomAD
CA291053548 rs201999452	293	V>I		No	ClinGen Ensembl
rs1392957226 CA400312099	294	D>G		No	ClinGen gnomAD
CA400312093 rs1240174496	295	Y>H		No	ClinGen gnomAD
rs973240616 CA291052200	296	A>D		No	ClinGen TOPMed
rs1330795694 CA400312084	296	A>S		No	ClinGen gnomAD
rs1301478111 CA400312077	297	S>T		No	ClinGen gnomAD
rs1406846382 CA400312058	299	Y>*		No	ClinGen TOPMed gnomAD
CA291052194 rs962128143	302	L>P		No	ClinGen TOPMed
CA8631332 rs555739301	304	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1410029792 CA400312004	307	G>D		No	ClinGen gnomAD
TCGA novel	308	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs909838772 CA291052188	311	D>E		No	ClinGen Ensembl
CA8631330 rs536068830	311	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774022799 CA8631329	313	L>P		No	ClinGen ExAC gnomAD
CA400311959 rs1426808016	314	S>A		No	ClinGen gnomAD
CA400311956 rs1201053878	314	S>F		No	ClinGen gnomAD
CA400311961 rs1426808016	314	S>T		No	ClinGen gnomAD
rs1234259563 CA400311953	315	F>V		No	ClinGen TOPMed
rs1276765734 CA400311943	316	Q>R		No	ClinGen TOPMed
CA8631326 rs368166369	317	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs762638366 CA8631327	317	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8631325 rs148912908	318	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs745681170 CA8631324	318	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs746994680 CA8631321 CA8631322	319	D>E		No	ClinGen ExAC TOPMed gnomAD
CA8631323 rs776507061	319	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1225640924 CA400311921	321	I>L		No	ClinGen gnomAD
CA400311912 rs1346380610	322	R>C		No	ClinGen gnomAD
CA8631319 rs146750859	322	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8631320 rs146750859	322	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA400311866 rs1217685535	327	E>A		No	ClinGen TOPMed gnomAD
CA400311865 rs1217685535	327	E>G		No	ClinGen TOPMed gnomAD
CA400311857 rs1282267524	328	Y>C		No	ClinGen gnomAD
CA400311861 rs1317251061	328	Y>D		No	ClinGen TOPMed gnomAD
rs1419759414 CA400311840	330	M>I		No	ClinGen TOPMed
CA8631264 rs767395301	330	M>T		No	ClinGen ExAC gnomAD
rs761625794 CA8631263	334	W>G		No	ClinGen ExAC gnomAD
CA8631262 rs774415489	335	V>G		No	ClinGen ExAC gnomAD
rs1381147127 CA400311784	338	L>P		No	ClinGen gnomAD
rs1287560564 CA400311779	339	N>T		No	ClinGen gnomAD
CA400311769 rs1346698835	340	S>I		No	ClinGen Ensembl
rs763142121 CA8631260	340	S>R		No	ClinGen ExAC gnomAD
rs143407064 CA8631256	342	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs143407064 CA8631257	342	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA8631258 rs770175322	342	V>F		No	ClinGen ExAC TOPMed gnomAD
rs770175322 CA400311761	342	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1598351283 CA400311751	344	I>V		No	ClinGen Ensembl
rs761632125 CA8631255	346	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8631254 rs373548020	349	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	353	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA291047950 rs932820063	354	F>S		No	ClinGen Ensembl
CA400311674 rs754416960	355	E>D		No	ClinGen ExAC TOPMed gnomAD
CA291047949 rs772095586	356	V>L		No	ClinGen Ensembl
CA400311652 rs1188149160	358	E>D		No	ClinGen gnomAD
rs867194496	360	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1486140937 CA400311643	360	R>R		No	ClinGen gnomAD

No associated diseases with Q86WV1

3 regional properties for Q86WV1

Type	Name	Position	InterPro Accession
domain	SH3 domain	294 - 355	IPR001452
domain	Pleckstrin homology domain	107 - 212	IPR001849
domain	Src kinase-associated phosphoprotein 1, SH3 domain	298 - 350	IPR035765

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Cell membrane	Upon T-cell stimulation, translocates to lipid rafts at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
immunological synapse	An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasma membrane raft	A membrane raft that is part of the plasma membrane.
T cell receptor complex	A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.

4 GO annotations of molecular function

Name	Definition
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein phosphatase binding	Binding to a protein phosphatase.
SH2 domain binding	Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
SH3 domain binding	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

11 GO annotations of biological process

Name	Definition
adaptive immune response	An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
positive regulation of adaptive immune response	Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
positive regulation of cell-cell adhesion mediated by integrin	Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin.
positive regulation of cell-matrix adhesion	Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of heterotypic cell-cell adhesion	Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion.
positive regulation of integrin activation	Any process that activates or increases the frequency, rate, or extent of integrin activation.
positive regulation of leukocyte cell-cell adhesion	Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
T cell receptor signaling pathway	The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O75563	SKAP2	Src kinase-associated phosphoprotein 2	Homo sapiens (Human)	PR
Q6DII7	skap1	Src kinase-associated phosphoprotein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MQAAALPEEI	RWLLEDAEEF	LAEGLRNENL	SAVARDHRDH	ILRGFQQIKA	RYYWDFQPQG
70	80	90	100	110	120
GDIGQDSSDD	NHSGTLGLSL	TSDAPFLSDY	QDEGMEDIVK	GAQELDNVIK	QGYLEKKSKD
130	140	150	160	170	180
HSFFGSEWQK	RWCVVSRGLF	YYYANEKSKQ	PKGTFLIKGY	GVRMAPHLRR	DSKKESCFEL
190	200	210	220	230	240
TSQDRRSYEF	TATSPAEARD	WVDQISFLLK	DLSSLTIPYE	EDEEEEEKEE	TYDDIDGFDS
250	260	270	280	290	300
PSCGSQCRPT	ILPGSVGIKE	PTEEKEEEDI	YEVLPDEEHD	LEEDESGTRR	KGVDYASYYQ
310	320	330	340	350
GLWDCHGDQP	DELSFQRGDL	IRILSKEYNM	YGWWVGELNS	LVGIVPKEYL	TTAFEVEER