AiPD: Autoinhibited Protein Database

O75563

Gene name	SKAP2 (PRAP, RA70, SAPS, SCAP2, SKAP55R)
Protein name	Src kinase-associated phosphoprotein 2
Names	Pyk2/RAFTK-associated protein, Retinoic acid-induced protein 70, SKAP55 homolog, SKAP-55HOM, SKAP-HOM, Src family-associated phosphoprotein 2, Src kinase-associated phosphoprotein 55-related protein, Src-associated adapter protein with PH and SH3 domains
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8935
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-113 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

38-113 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O75563

Entry ID	Method	Resolution	Chain	Position	Source
3OMH	X-ray	290 A	E/F/G/H	71-79	PDB
AF-O75563-F1	Predicted				AlphaFoldDB

236 variants for O75563

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1243108044 CA367231772	2	P>L		No	ClinGen TOPMed gnomAD
rs1185879796 CA367231760	4	P>R		No	ClinGen gnomAD
rs1341703922 CA367231761	4	P>S		No	ClinGen TOPMed
CA4195770 rs754298536	5	S>G		No	ClinGen ExAC gnomAD
CA367231741 rs1209564946	7	T>A		No	ClinGen TOPMed gnomAD
CA367231740 rs1209564946	7	T>S		No	ClinGen TOPMed gnomAD
CA4195766 rs534073665	10	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA4195765 rs199915571	11	Y>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4195764 RCV000956470 rs137938529	12	P>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA367231705 rs1380278034	13	L>F		No	ClinGen gnomAD
CA367231699 rs1335708568	14	P>S		No	ClinGen gnomAD
CA367231670 rs369206020	18	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4195761 rs369206020	18	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4195760 rs369206020	18	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs140914133 CA4195759	20	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	29	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1290939528 CA367231570	31	I>T		No	ClinGen gnomAD
TCGA novel	36	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759161151 CA4195743	36	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1341177258 CA367231532	37	L>V		No	ClinGen gnomAD
rs776279217 CA4195742	41	A>G		No	ClinGen ExAC gnomAD
rs1226193050 CA367231487	43	E>G		No	ClinGen TOPMed gnomAD
CA4195741 rs771052066	45	R>G		No	ClinGen ExAC gnomAD
rs1217746103 CA367231456	47	S>F		No	ClinGen TOPMed
rs1217746103 CA367231458	47	S>Y		No	ClinGen TOPMed
CA4195739 rs145659190	49	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA156329156 rs151047705	49	I>V		No	ClinGen ESP TOPMed gnomAD
CA367231435 rs1584428981	51	K>E		No	ClinGen Ensembl
rs1309162169 CA367231422	52	I>M		No	ClinGen gnomAD
CA156329155 rs993462710	54	D>N		No	ClinGen TOPMed
CA367231406 rs1394745071	55	V>I		No	ClinGen gnomAD
CA4195736 rs140223829	58	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA156329154 rs140223829	58	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4195737 rs140223829	58	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA367231366 rs1461593957	59	Y>C		No	ClinGen gnomAD
CA4195715 rs375826440	61	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA367231356 rs1201354278	61	Q>K		No	ClinGen gnomAD
CA367231352 rs1322258368	61	Q>R		No	ClinGen gnomAD
CA156329114 rs112160989	64	Q>R		No	ClinGen Ensembl
rs1225977051 CA367231323	65	D>A		No	ClinGen gnomAD
CA367231317 rs1371891891	66	K>E		No	ClinGen gnomAD
CA367231315 rs1376256661	66	K>R		No	ClinGen TOPMed
CA367231295 rs1399065436	67	G>D		No	ClinGen TOPMed gnomAD
rs1303823862 CA367231310	67	G>S		No	ClinGen TOPMed
CA367231290 rs1290845343	68	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4195696 rs368498535	69	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4195695 rs761724642	71	D>A		No	ClinGen ExAC TOPMed gnomAD
CA367231267 rs761724642	71	D>V		No	ClinGen ExAC TOPMed gnomAD
CA367231262 rs1315585706	72	G>E		No	ClinGen TOPMed
CA4195694 rs774143292	72	G>R		No	ClinGen ExAC gnomAD
CA367231255 rs1218598646	73	E>G		No	ClinGen TOPMed
rs147926422 CA4195692	74	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367231249 rs1161512164	74	E>K		No	ClinGen gnomAD
CA367231240 rs1419848946	75	Y>C		No	ClinGen gnomAD
rs775739380 CA4195691	76	D>G		No	ClinGen ExAC TOPMed gnomAD
rs775739380 CA367231232	76	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1584422689 CA367231226	77	D>A		No	ClinGen Ensembl
rs1484622375 CA367231223	77	D>E		No	ClinGen gnomAD
rs770027415 CA4195690	78	P>L		No	ClinGen ExAC
CA367231221 rs1240960067	78	P>T		No	ClinGen TOPMed gnomAD
CA367231206 rs1454457277	80	A>S		No	ClinGen TOPMed
rs1454457277 CA367231208	80	A>T		No	ClinGen TOPMed
CA156328006 rs778197962	81	G>E		No	ClinGen ExAC TOPMed gnomAD
CA4195688 rs778197962	81	G>V		No	ClinGen ExAC TOPMed gnomAD
rs781322288 CA4195687	83	P>S		No	ClinGen ExAC gnomAD
CA156328003 rs926723062	85	T>S		No	ClinGen TOPMed
CA4195684 rs140944912	86	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4195685 rs747451796	86	I>V		No	ClinGen ExAC gnomAD
CA4195683 rs758783711	87	S>*		No	ClinGen ExAC gnomAD
CA367231136 rs1584422637	92	R>*		No	ClinGen Ensembl
CA156328002 rs982512587	92	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA4195679 rs200204065	94	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs574563137 CA4195678	95	K>E		No	ClinGen 1000Genomes ExAC
CA367231109 rs1279298404	96	D>Y		No	ClinGen TOPMed
rs1426305212 CA367231100	97	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	97	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4195676 rs763997613	99	A>G		No	ClinGen ExAC TOPMed gnomAD
rs763997613 CA4195675	99	A>V		No	ClinGen ExAC TOPMed gnomAD
rs775355459 CA4195674	100	P>L		No	ClinGen ExAC gnomAD
rs775355459 CA4195673	100	P>R		No	ClinGen ExAC gnomAD
rs913893751 CA156327999	101	S>C		No	ClinGen Ensembl
CA156328000 rs913893751	101	S>Y		No	ClinGen Ensembl
rs760873604 CA4195647	105	Q>H		No	ClinGen ExAC gnomAD
rs771252306 CA4195648	105	Q>R		No	ClinGen ExAC gnomAD
rs1337017647 CA367230806	107	P>H		No	ClinGen gnomAD
TCGA novel	108	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA156316494 rs1004787966	109	I>T		No	ClinGen TOPMed
rs773420570 CA4195646	109	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4195645 rs772763425	111	A>S		No	ClinGen ExAC gnomAD
CA367230780 rs1171417915	112	Q>*		No	ClinGen gnomAD
CA367230782 rs1171417915	112	Q>K		No	ClinGen gnomAD
TCGA novel	115	P>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs924911955 CA156316492	115	P>T		No	ClinGen TOPMed
rs574072209 CA4195644	120	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367230728 rs574072209	120	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4195643 rs574072209	120	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM223150 CA156316490 rs1025140851	126	R>C	ovary Variant assessed as Somatic; 0.0 impact. skin [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
COSM331555 rs372903599 CA4195642	126	R>H	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs1209596632 CA367230671	128	K>N		No	ClinGen TOPMed
rs754848310 CA4195632	131	S>T		No	ClinGen ExAC gnomAD
CA367230629 rs1267477894	132	F>S		No	ClinGen TOPMed
TCGA novel	134	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4195629 rs375337222	138	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4195627 rs367722228	140	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs866446687 COSM3411953 CA156316386 COSM2153652	140	R>W	Variant assessed as Somatic; impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1472790853 CA367230570	141	W>R		No	ClinGen TOPMed
CA367230553 rs1224506623	143	A>P		No	ClinGen gnomAD
rs553801337 CA156316385	144	L>V		No	ClinGen 1000Genomes TOPMed
CA4195625 rs146206173	147	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel CA4195623 rs775819356	149	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC TOPMed gnomAD
rs201686969 CA4195621	150	Y>C		No	ClinGen 1000Genomes ExAC
CA367230509 rs1562592925	150	Y>N		No	ClinGen Ensembl
CA367230478 rs1398840169	154	S>G		No	ClinGen gnomAD
rs746602552 CA4195620	155	D>N		No	ClinGen ExAC gnomAD
rs777299001 CA4195619	156	K>T		No	ClinGen ExAC gnomAD
CA367230432 rs1264398113	158	K>Q		No	ClinGen gnomAD
rs1476659212 CA367230383	164	F>Y		No	ClinGen TOPMed
rs369201328 CA4195593	166	I>V		No	ClinGen ESP ExAC gnomAD
CA367230350 rs1280637842	169	Y>C		No	ClinGen gnomAD
rs1444880208 CA367230344	170	S>G		No	ClinGen gnomAD
CA4195592 rs757408710	171	V>I		No	ClinGen ExAC gnomAD
CA4195591 rs751674814	176	T>A		No	ClinGen ExAC gnomAD
CA4195590 rs764017598	176	T>I		No	ClinGen ExAC gnomAD
CA367230296 rs764017598	176	T>S		No	ClinGen ExAC gnomAD
rs763551490 CA4195587	180	D>N		No	ClinGen ExAC TOPMed gnomAD
CA367230268 rs1174452200	181	G>R		No	ClinGen gnomAD
rs1028000989 CA156315147	183	K>N		No	ClinGen Ensembl
CA367230206 rs1159042555	189	I>V		No	ClinGen gnomAD
rs753156779 CA4195585	190	S>T		No	ClinGen ExAC TOPMed gnomAD
rs765714494 CA4195584	191	A>T		No	ClinGen ExAC gnomAD
rs150725979 CA4195583	193	D>N		No	ClinGen ESP ExAC gnomAD
rs1244594951 CA367230166	195	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM184196 CA156315146 rs199985669	195	R>H	large_intestine central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes
CA367230168 rs1244594951	195	R>S		No	ClinGen TOPMed gnomAD
CA4195581 rs771812040	196	I>L		No	ClinGen ExAC gnomAD
CA367230162 rs771812040	196	I>V		No	ClinGen ExAC gnomAD
CA156315038 COSM4155706 rs868153077	200	T>I	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	201	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4195566 rs760020231	202	A>G		No	ClinGen ExAC gnomAD
rs1129771 CA4195567 VAR_029812	202	A>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA367230096 rs1238947869	204	P>L		No	ClinGen TOPMed
CA367230094 rs1179722170	205	K>E		No	ClinGen gnomAD
CA156315036 rs928514749	205	K>R		No	ClinGen TOPMed
rs928514749 CA156315037	205	K>T		No	ClinGen TOPMed
rs754212424 CA4195565	206	D>H		No	ClinGen ExAC gnomAD
rs766583577 CA4195564	206	D>V		No	ClinGen ExAC
CA4195563 rs761555788	209	E>K		No	ClinGen ExAC gnomAD
CA4195562 rs375906049	216	F>C		No	ClinGen ESP ExAC gnomAD
CA4195561 rs763778638	217	V>I		No	ClinGen ExAC gnomAD
rs1285913351 CA367229995	219	Q>R		No	ClinGen gnomAD
rs766788347 CA4195545	221	M>T		No	ClinGen ExAC gnomAD
CA4195546 rs754256737	221	M>V		No	ClinGen ExAC gnomAD
CA367229945 rs750796906	224	D>G		No	ClinGen ExAC gnomAD
CA4195543 rs750796906	224	D>V		No	ClinGen ExAC gnomAD
CA4195542 rs138740188	225	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA367229935 rs1388294383	226	I>F		No	ClinGen TOPMed
CA367229913 rs1562588397	229	D>Y		No	ClinGen Ensembl
rs1369467943 CA367229904	230	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1457202946 CA367229891	232	E>*		No	ClinGen gnomAD
COSM145935 CA4195539 rs775145779	240	V>I	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs576214855 CA4195538	241	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367229819 rs759571033	242	H>N		No	ClinGen ExAC TOPMed gnomAD
CA4195537 rs759571033	242	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1435358707 CA367229803	244	L>P		No	ClinGen gnomAD
rs1056749629 CA156315016	247	S>N		No	ClinGen TOPMed
rs1191038710 CA367229777	248	N>S		No	ClinGen gnomAD
CA367229764 rs1196944637	250	L>P		No	ClinGen gnomAD
rs17154402 CA367229745	253	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000971539 rs17154402 CA4195533 VAR_029813	253	S>T		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs772293020 CA367229729	255	P>L		No	ClinGen ExAC TOPMed gnomAD
rs772293020 CA4195532	255	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs775760577 CA4195530	256	I>K		No	ClinGen ExAC gnomAD
rs775760577 CA4195531	256	I>T		No	ClinGen ExAC gnomAD
rs749365286 CA4195528	259	E>D		No	ClinGen ExAC gnomAD
COSM1225817 CA367229694 rs1332974809	260	I>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	262	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367229668 rs1444046543	264	L>I		No	ClinGen gnomAD
TCGA novel	267	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142511976 CA4195506	268	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1562576654 CA367229608	269	E>D		No	ClinGen Ensembl
rs377087028 CA4195504	270	D>G		No	ClinGen ESP ExAC
CA4195502 rs770208860	273	P>S		No	ClinGen ExAC gnomAD
CA367229512 rs1353655510	283	S>G		No	ClinGen TOPMed
rs1289965857 CA367229494	285	D>G		No	ClinGen TOPMed
rs781709750 CA4195500	285	D>N		No	ClinGen ExAC gnomAD
rs1196651072 CA367229472	288	H>R		No	ClinGen TOPMed
rs751945383 CA4195497	289	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA367229456 rs1223845787	290	T>I		No	ClinGen Ensembl
CA367229455 rs1199809442	291	S>P		No	ClinGen gnomAD
CA156310949 rs912535651	293	D>E		No	ClinGen TOPMed
CA4195478 rs754587616	293	D>N		No	ClinGen ExAC gnomAD
CA4195479 rs754587616	293	D>Y		No	ClinGen ExAC gnomAD
CA367229423 rs1191371181	294	K>R		No	ClinGen gnomAD
CA4195477 rs753487208	295	S>N		No	ClinGen ExAC gnomAD
CA4195476 rs779449511	296	T>A		No	ClinGen ExAC gnomAD
CA367229406 rs1211273405	296	T>I		No	ClinGen gnomAD
CA4195475 rs755696213	297	D>H		No	ClinGen ExAC gnomAD
CA367229405 rs755696213	297	D>N		No	ClinGen ExAC gnomAD
CA367229361 rs1227565637	302	Y>*		No	ClinGen gnomAD
rs767510572 CA4195473	303	Q>P		No	ClinGen ExAC gnomAD
rs1344115486 CA367229329	307	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	311	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4195470 rs763910549	311	A>T		No	ClinGen ExAC gnomAD
CA4195468 rs375431686	312	F>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs759760076 CA4195466	315	E>K		No	ClinGen ExAC gnomAD
rs935424410 CA156310948	317	S>*		No	ClinGen TOPMed
rs1421517267 CA367229232	317	S>P		No	ClinGen gnomAD
CA4195464 rs771575048	320	R>C		No	ClinGen ExAC gnomAD
rs747450045 CA4195463	320	R>H		No	ClinGen ExAC gnomAD
CA367231035 rs1183845237	332	N>H		No	ClinGen TOPMed
rs960557345 CA156309490	332	N>S		No	ClinGen Ensembl
CA156309489 rs368995717	333	R>G		No	ClinGen Ensembl
CA4195436 rs780703919	334	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	337	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4195434 rs200813179	337	W>G		No	ClinGen ExAC gnomAD
rs752555197 CA4195432	338	V>E		No	ClinGen ExAC gnomAD
CA4195431 rs752555197	338	V>G		No	ClinGen ExAC gnomAD
rs777836964 CA4195433	338	V>L		No	ClinGen ExAC
rs569488841 CA4195427	339	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA4195425 rs766684331	340	E>K		No	ClinGen ExAC
CA367230969 rs1177581750	341	M>I		No	ClinGen gnomAD
CA367230964 rs1472854793	342	K>R		No	ClinGen gnomAD
COSM1622734 rs374798019 CA4195424	345	I>V	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs750463812 CA4195423	347	L>F		No	ClinGen ExAC gnomAD
CA156309488 rs1031856593	348	V>M		No	ClinGen Ensembl
CA156309487 rs998997425	349	P>S		No	ClinGen gnomAD
CA4195422 rs191537857	351	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA837167058 rs1360820774	352	Y>*		No	ClinGen Ensembl
CA4195421 rs762169255	353	I>L		No	ClinGen ExAC TOPMed gnomAD
rs762169255 CA367230899	353	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4195420 rs371274766	354	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4195419 rs113781509	355	E>G		No	ClinGen ExAC gnomAD
rs1282566565 CA367230874	356	M>I		No	ClinGen gnomAD
rs776308504 CA4195417	356	M>K		No	ClinGen ExAC gnomAD
CA4195418 rs763283732	356	M>V		No	ClinGen ExAC gnomAD
TCGA novel	358	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with O75563

2 regional properties for O75563

Type	Name	Position	InterPro Accession
domain	SH3 domain	297 - 358	IPR001452
domain	Pleckstrin homology domain	116 - 221	IPR001849

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
B cell activation	The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q86WV1	SKAP1	Src kinase-associated phosphoprotein 1	Homo sapiens (Human)	PR

10	20	30	40	50	60
MPNPSSTSSP	YPLPEEIRNL	LADVETFVAD	ILKGENLSKK	AKEKRESLIK	KIKDVKSIYL
70	80	90	100	110	120
QEFQDKGDAE	DGEEYDDPFA	GPPDTISLAS	ERYDKDDEAP	SDGAQFPPIA	AQDLPFVLKA
130	140	150	160	170	180
GYLEKRRKDH	SFLGFEWQKR	WCALSKTVFY	YYGSDKDKQQ	KGEFAIDGYS	VRMNNTLRKD
190	200	210	220	230	240
GKKDCCFEIS	APDKRIYQFT	AASPKDAEEW	VQQLKFVLQD	MESDIIPEDY	DERGELYDDV
250	260	270	280	290	300
DHPLPISNPL	TSSQPIDDEI	YEELPEEEED	SAPVKVEEQR	KMSQDSVHHT	SGDKSTDYAN
310	320	330	340	350
FYQGLWDCTG	AFSDELSFKR	GDVIYILSKE	YNRYGWWVGE	MKGAIGLVPK	AYIMEMYDI