AiPD: Autoinhibited Protein Database

Q86U70

Gene name	LDB1 (CLIM2)
Protein name	LIM domain-binding protein 1
Names	LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, hLdb1, Nuclear LIM interactor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8861
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

263-360 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

263-360 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

9 structures for Q86U70

Entry ID	Method	Resolution	Chain	Position	Source
2XJY	X-ray	240 A	B	334-368	PDB
2XJZ	X-ray	280 A	I/J/K/L/M	334-368	PDB
2YPA	X-ray	280 A	D	336-375	PDB
6TYD	X-ray	280 A	V	56-285	PDB
7OB5	X-ray	180 A	P	401-411	PDB
7OB8	X-ray	180 A	B	401-411	PDB
8HIB	X-ray	245 A	V	56-285	PDB
8SSU	X-ray	289 A	A	231-294	PDB
AF-Q86U70-F1	Predicted				AlphaFoldDB

198 variants for Q86U70

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA377849215 rs1254777610	4	G>A		No	ClinGen gnomAD
rs780482579 CA377846835	9	G>D		No	ClinGen ExAC TOPMed gnomAD
rs780482579 CA5660541	9	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1355681900 CA377846758	13	K>R		No	ClinGen gnomAD
rs763253713 CA212174772	19	S>L		No	ClinGen gnomAD
CA212174768 rs1019837144	20	P>L		No	ClinGen gnomAD
CA377846020 rs1287820023	20	P>S		No	ClinGen gnomAD
rs547343320 CA5660538	22	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1405190254 CA377845978	23	P>R		No	ClinGen gnomAD
CA5660537 rs761961476	24	P>L		No	ClinGen ExAC gnomAD
CA5660535 rs201649218	26	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5660534 rs762949850	28	A>T		No	ClinGen ExAC gnomAD
CA377845918 rs1449588043	29	F>L		No	ClinGen TOPMed
CA377845908 rs1160820726	30	P>T		No	ClinGen gnomAD
CA377845892 rs776230908	31	P>H		No	ClinGen ExAC TOPMed gnomAD
CA5660531 rs776230908	31	P>L		No	ClinGen ExAC TOPMed gnomAD
rs776230908 CA5660530	31	P>R		No	ClinGen ExAC TOPMed gnomAD
CA377845886 rs1456602440	32	F>V		No	ClinGen TOPMed
CA377845875 rs1450866275	33	H>N		No	ClinGen gnomAD
rs770596778 CA5660529	33	H>Q		No	ClinGen ExAC gnomAD
CA377845851 rs777272483	35	G>C		No	ClinGen ExAC TOPMed gnomAD
rs777272483 CA5660527	35	G>R		No	ClinGen ExAC TOPMed gnomAD
CA212174745 rs777272483	35	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1411383662 CA377845835	36	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1375768973 CA377845787	41	D>Y		No	ClinGen gnomAD
CA5660524 rs780494241	42	V>M		No	ClinGen ExAC gnomAD
rs1436065075 CA377845757	43	G>A		No	ClinGen gnomAD
rs1436065075 CA377845759	43	G>D		No	ClinGen gnomAD
CA377845735 rs1365075722	44	P>L		No	ClinGen gnomAD
rs1442176036 CA377845737	44	P>S		No	ClinGen TOPMed gnomAD
CA377845725 rs1440518521	46	P>S		No	ClinGen TOPMed gnomAD
rs1233122876 CA377845719	47	M>L		No	ClinGen TOPMed
CA377845721 rs1233122876	47	M>V		No	ClinGen TOPMed
CA5660506 rs776042607	48	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA5660505 rs770225174	49	P>A		No	ClinGen ExAC gnomAD
CA377845693 rs1318426179	49	P>Q		No	ClinGen gnomAD
rs770225174 CA377845697	49	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA377845686 rs1392938518	50	P>S		No	ClinGen gnomAD
rs938626844 CA212174553	51	T>S		No	ClinGen Ensembl
CA5660503 rs781692988	53	L>V		No	ClinGen ExAC gnomAD
rs757494369 CA5660502	55	P>S		No	ClinGen ExAC gnomAD
CA377845610 rs1445964676	57	I>T		No	ClinGen TOPMed
rs1345683599 CA377845524	61	T>I		No	ClinGen TOPMed
CA377845504 rs755881985	63	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA5660475 rs755881985	63	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA5660474 rs200658541	65	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1463085489 CA377845470	66	Q>P		No	ClinGen TOPMed gnomAD
CA377845427 rs1164083234	68	D>E		No	ClinGen gnomAD
rs761376100 CA5660472	69	Y>C		No	ClinGen ExAC gnomAD
rs767158126 CA5660473	69	Y>N		No	ClinGen ExAC gnomAD
CA212174385 rs12767417	75	N>T		No	ClinGen Ensembl
rs777243026 CA5660468	77	R>Q		No	ClinGen ExAC gnomAD
rs762616778 CA377845265	77	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs898675596 CA212174377	81	W>C		No	ClinGen Ensembl
rs201588496 CA5660451	87	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766930665 CA5660450	88	L>F		No	ClinGen ExAC TOPMed gnomAD
CA5660449 rs761104389	91	D>G		No	ClinGen ExAC gnomAD
rs1231889564 CA377844809	92	A>E		No	ClinGen gnomAD
CA5660445 rs774536883	95	T>S		No	ClinGen ExAC gnomAD
CA5660443 rs749326604	105	T>S		No	ClinGen ExAC gnomAD
rs780111951 CA5660442	108	F>L		No	ClinGen ExAC gnomAD
rs1392630711 CA377844305	110	L>V		No	ClinGen TOPMed
CA5660441 rs769661160	111	E>D		No	ClinGen ExAC gnomAD
rs1428316921 CA377844218	112	D>G		No	ClinGen TOPMed
CA377844109 rs1455886550	116	R>K		No	ClinGen gnomAD
CA377844093 rs1564912926	117	Y>C		No	ClinGen Ensembl
rs1391848028 CA377844063	118	T>A		No	ClinGen TOPMed
rs962843747 CA212174083	118	T>N		No	ClinGen Ensembl
CA377843841 rs1356417431 COSM215407	121	R>W	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5660412 rs767872374	126	R>C		No	ClinGen ExAC gnomAD
rs757787986 CA5660411	126	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1185246709 CA377843695	127	Y>S		No	ClinGen gnomAD
rs751862555 CA5660410	129	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5660409 rs764429245	129	R>H		No	ClinGen ExAC TOPMed gnomAD
rs199713070 CA5660407	133	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1334446781 CA377843442	133	E>V		No	ClinGen TOPMed
CA377843362 rs1435826108	136	A>T		No	ClinGen gnomAD
CA212174041 rs144764727	137	T>M		No	ClinGen ESP TOPMed
CA377843122 rs1204629069	142	V>G		No	ClinGen TOPMed
rs770703563 CA5660403	145	H>P		No	ClinGen ExAC
CA212174010 rs886165782	147	K>R		No	ClinGen Ensembl
CA5660400 rs771963891	149	A>T		No	ClinGen ExAC
CA377842864 rs1357297095	150	F>L		No	ClinGen gnomAD
rs149408048 CA5660399	152	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs143495877 CA5660396	157	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA377842596 COSM1188030 COSM1188031 rs1392988031	158	D>N	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1044703972 CA212173946	162	G>C		No	ClinGen TOPMed gnomAD
rs1044703972 CA212173948	162	G>S		No	ClinGen TOPMed gnomAD
rs778290861 CA5660392	171	P>H		No	ClinGen ExAC gnomAD
CA377842063 rs1310876905	172	M>I		No	ClinGen TOPMed
CA377842088 rs1273280872	172	M>L		No	ClinGen TOPMed gnomAD
rs1346120164 CA377841697	179	E>D		No	ClinGen gnomAD
COSM426966 COSM1474315 CA377841615 rs1220258853	183	Y>H	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
rs373038125 CA5660372	187	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5660371 rs188642585	190	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs754063958 CA5660370	191	M>I		No	ClinGen ExAC gnomAD
rs1298371315 CA377841389	191	M>T		No	ClinGen gnomAD
COSM2058822 CA5660369 COSM302541 rs766563001	193	R>W	Variant assessed as Somatic; 4.705e-05 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA377841273 rs1590281775	198	H>P		No	ClinGen Ensembl
rs1264035751 CA377841152	202	R>Q		No	ClinGen gnomAD
CA212173625 rs919693683 COSM1345423 COSM1345422	202	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs761857156 CA377841080	205	R>L		No	ClinGen ExAC gnomAD
CA5660365 rs761857156	205	R>Q		No	ClinGen ExAC gnomAD
rs1282894133 CA377841076	206	E>K		No	ClinGen gnomAD
CA5660364 rs774214210	206	E>V		No	ClinGen ExAC gnomAD
rs749985868 CA212173595	207	L>F		No	ClinGen Ensembl
CA5660363 rs768491598	209	P>S		No	ClinGen ExAC gnomAD
rs1216848177 CA377841008	210	R>C		No	ClinGen gnomAD
rs762694194 CA5660362	210	R>H		No	ClinGen ExAC TOPMed gnomAD
CA377840969 rs1590281656	213	L>V		No	ClinGen Ensembl
CA377840948 rs1353253496	214	A>D		No	ClinGen TOPMed gnomAD
rs1413778386 CA377840954	214	A>P		No	ClinGen TOPMed gnomAD
rs1466404255 CA377840933	215	M>L		No	ClinGen gnomAD
CA377840928 rs1353731068	215	M>T		No	ClinGen gnomAD
rs769457773 CA5660360	216	H>Q		No	ClinGen ExAC gnomAD
CA377840724 rs1377520634	218	Q>E		No	ClinGen gnomAD
rs1325080408 CA377840674	220	P>S		No	ClinGen gnomAD
rs147037173 CA5660332	222	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA5660330 rs139160379	225	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA377840490 rs1392882608	225	Q>R		No	ClinGen gnomAD
rs764051483 CA5660329	230	I>M		No	ClinGen ExAC gnomAD
rs34707683 CA212173400	230	I>T		No	ClinGen Ensembl
CA377840330 rs1343697945	231	T>S		No	ClinGen gnomAD
rs184966094 CA212173394	232	R>W		No	ClinGen 1000Genomes TOPMed
CA5660328 rs758269767	233	C>G		No	ClinGen ExAC gnomAD
CA212173387 rs34668927	233	C>S		No	ClinGen Ensembl
rs759369989 CA5660325	237	N>S		No	ClinGen ExAC gnomAD
CA5660323 rs766046306	241	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1209983970 CA377840075	242	Y>C		No	ClinGen gnomAD
CA377839896 rs1488418952	250	E>K		No	ClinGen gnomAD
CA377839873 rs1279342132	251	P>R		No	ClinGen gnomAD
rs765994038 CA5660304	253	Q>E		No	ClinGen ExAC gnomAD
rs760258946 CA5660303	263	S>N		No	ClinGen ExAC gnomAD
rs1446249347 CA377839645	267	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs796461509 CA212173239	268	D>E		No	ClinGen gnomAD
rs761428646 CA5660300	269	C>S		No	ClinGen ExAC gnomAD
rs1400823826 CA377839610	272	T>N		No	ClinGen gnomAD
rs1311407440 CA377839551	280	R>C		No	ClinGen gnomAD
CA377839552 rs1311407440	280	R>G		No	ClinGen gnomAD
rs1387060330 CA377839550	280	R>H		No	ClinGen TOPMed
rs373863079 CA5660298	282	V>L		No	ClinGen ESP ExAC TOPMed
CA5660271 rs748162410	286	A>V		No	ClinGen ExAC gnomAD
rs561553415 CA5660269	290	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs749220036 CA5660268	292	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs1396778383 CA377839184	297	R>Q		No	ClinGen gnomAD
VAR_036366 rs990101456 CA212173026 COSM1345421 COSM33199	299	R>Q	large_intestine Variant assessed as Somatic; impact. a colorectal cancer sample; somatic mutation [Cosmic, NCI-TCGA, UniProt]	No	ClinGen cosmic curated UniProt NCI-TCGA TOPMed dbSNP
CA377839082 rs1590280465	301	M>I		No	ClinGen Ensembl
CA377839038 rs1300183004	305	S>G		No	ClinGen TOPMed
rs1326579967 CA377839015	307	M>T		No	ClinGen TOPMed
rs370177977 CA5660265	307	M>V		No	ClinGen ExAC TOPMed gnomAD
CA377838968 rs780666243	309	S>C		No	ClinGen ExAC gnomAD
CA5660264 rs780666243	309	S>F		No	ClinGen ExAC gnomAD
CA5660263 rs756973927	310	G>S		No	ClinGen ExAC gnomAD
CA377838914 rs1437536591	312	G>A		No	ClinGen gnomAD
rs1432873447 CA377838918	312	G>S		No	ClinGen TOPMed gnomAD
CA5660262 rs751055946	313	N>T		No	ClinGen ExAC TOPMed gnomAD
rs763679443 CA5660261	315	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1245036842 CA377838821	316	N>S		No	ClinGen gnomAD
rs754264863 CA5660260	318	N>K		No	ClinGen ExAC gnomAD
rs766955952 CA5660258	319	S>I		No	ClinGen ExAC TOPMed gnomAD
rs766955952 CA212172991	319	S>N		No	ClinGen ExAC TOPMed gnomAD
rs148871407 CA5660257 COSM3934899 COSM3934900	322	K>R	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5660256 rs773634189	324	P>T		No	ClinGen ExAC TOPMed gnomAD
CA377838500 rs1310467341	325	A>V		No	ClinGen gnomAD
CA5660252 rs768693158 COSM1584758 COSM266813	329	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs775239408 CA5660250	331	S>P		No	ClinGen ExAC TOPMed gnomAD
CA5660218 rs757570010	348	G>R		No	ClinGen ExAC gnomAD
CA5660217 COSM200220 rs751950349	353	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5660215 rs763248283	355	E>V		No	ClinGen ExAC gnomAD
CA377837285 rs1416390062	360	R>Q		No	ClinGen gnomAD
CA5660213 rs765351164	360	R>W		No	ClinGen ExAC gnomAD
rs776684327 CA5660211	368	A>T		No	ClinGen ExAC gnomAD
CA5660210 rs771012981	369	A>T		No	ClinGen ExAC
rs375534318 CA212172505	371	G>S		No	ClinGen ESP TOPMed gnomAD
CA377836803 rs1319622754	374	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5660205 CA377836751 rs768403370	375	E>D		No	ClinGen ExAC TOPMed gnomAD
CA5660206 COSM275834 rs531176307	375	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs201759181 CA212172475	379	N>I		No	ClinGen ExAC TOPMed gnomAD
CA5660203 rs201759181	379	N>S		No	ClinGen ExAC TOPMed gnomAD
rs563847702 CA5660202	380	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1396083162 CA377836599	380	N>S		No	ClinGen gnomAD
rs141161148 CA5660199	386	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs141161148 CA5660198	386	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA377836454 rs1351873438	387	N>S		No	ClinGen gnomAD
CA377836444 rs942330225	388	S>C		No	ClinGen TOPMed
CA212172440 rs942330225	388	S>R		No	ClinGen TOPMed
CA377836410 rs1439415369	389	P>L		No	ClinGen gnomAD
rs1378861409 CA377836346	392	S>T		No	ClinGen TOPMed gnomAD
rs1038866820 CA212172434	395	P>L		No	ClinGen TOPMed gnomAD
rs755033362 CA5660195	398	Q>E		No	ClinGen ExAC gnomAD
rs143992634 CA5660194	400	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA5660193 rs766364480	402	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1283637045 CA377836039	405	P>S		No	ClinGen gnomAD
rs773354858 CA212172425 COSM1345420	406	T>M	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773354858 CA5660191	406	T>R		No	ClinGen ExAC TOPMed gnomAD
CA377835963 rs1385205763	409	A>P		No	ClinGen gnomAD
rs774007214 CA5660188	409	A>V		No	ClinGen ExAC
CA5660187 rs768226147	410	S>F		No	ClinGen ExAC gnomAD

No associated diseases with Q86U70

1 regional properties for Q86U70

Type	Name	Position	InterPro Accession
domain	LIM interaction domain	336 - 375	IPR041363

Functions

		Description
EC Number
Subcellular Localization	Nucleus	Colocalizes with SLK at leading edges
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
beta-catenin-TCF complex	A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.
cell leading edge	The area of a motile cell closest to the direction of movement.
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

9 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
LIM domain binding	Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein self-association	Binding to a domain within the same polypeptide.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
transcription coregulator activity	A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

25 GO annotations of biological process

Name	Definition
anterior/posterior axis specification	The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cellular component assembly	The aggregation, arrangement and bonding together of a cellular component.
cerebellar Purkinje cell differentiation	The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.
epithelial structure maintenance	A tissue homeostatic process required for the maintenance of epithelial structure.
gastrulation with mouth forming second	A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
hair follicle development	The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
histone H3-K4 acetylation	The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone.
mesendoderm development	The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of erythrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.
positive regulation of cell adhesion	Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of hemoglobin biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.
regulation of focal adhesion assembly	Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
regulation of kinase activity	Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
regulation of transcription elongation by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
somatic stem cell population maintenance	Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O42252	LDB1	LIM domain-binding protein 1	Gallus gallus (Chicken)	PR
P70662	Ldb1	LIM domain-binding protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSVGCACPGC	SSKSFKLYSP	KEPPNGNAFP	PFHPGTMLDR	DVGPTPMYPP	TYLEPGIGRH
70	80	90	100	110	120
TPYGNQTDYR	IFELNKRLQN	WTEECDNLWW	DAFTTEFFED	DAMLTITFCL	EDGPKRYTIG
130	140	150	160	170	180
RTLIPRYFRS	IFEGGATELY	YVLKHPKEAF	HSNFVSLDCD	QGSMVTQHGK	PMFTQVCVEG
190	200	210	220	230	240
RLYLEFMFDD	MMRIKTWHFS	IRQHRELIPR	SILAMHAQDP	QMLDQLSKNI	TRCGLSNSTL
250	260	270	280	290	300
NYLRLCVILE	PMQELMSRHK	TYSLSPRDCL	KTCLFQKWQR	MVAPPAEPTR	QQPSKRRKRK
310	320	330	340	350	360
MSGGSTMSSG	GGNTNNSNSK	KKSPASTFAL	SSQVPDVMVV	GEPTLMGGEF	GDEDERLITR
370	380	390	400	410
LENTQFDAAN	GIDDEDSFNN	SPALGANSPW	NSKPPSSQES	KSENPTSQAS	Q