O42252

PR
Gene name
LDB1
Protein name
LIM domain-binding protein 1
Names
LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, cLdb1, Neural Src-interacting protein, Nuclear LIM interactor
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395952
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

266-343 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42252

Entry ID Method Resolution Chain Position Source
AF-O42252-F1 Predicted AlphaFoldDB

15 variants for O42252

Variant ID(s) Position Change Description Diseaes Association Provenance
rs732846400 52 Y>H No Ensembl
rs734743421 52 Y>S No Ensembl
rs737757509 82 T>A No Ensembl
rs737507126 142 V>G No Ensembl
rs732588468 149 S>P No Ensembl
rs738342049 177 C>W No Ensembl
rs740255322 178 V>G No Ensembl
rs735533354 179 E>G No Ensembl
rs737497207 183 Y>F No Ensembl
rs740427247 261 T>P No Ensembl
rs1060467180 368 A>T No Ensembl
rs315445036 380 N>T No Ensembl
rs1057979215 382 P>S No Ensembl
rs317242903 387 N>T No Ensembl
rs1059972275 396 S>A No Ensembl

No associated diseases with O42252

1 regional properties for O42252

Type Name Position InterPro Accession
domain Lateral organ boundaries, LOB 7 - 108 IPR004883

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

3 GO annotations of molecular function

Name Definition
LIM domain binding Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
protein homodimerization activity Binding to an identical protein to form a homodimer.
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

7 GO annotations of biological process

Name Definition
anterior/posterior axis specification The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
negative regulation of erythrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86U70 LDB1 LIM domain-binding protein 1 Homo sapiens (Human) PR
P70662 Ldb1 LIM domain-binding protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSVGCACPGC SSKSFKLYSP KEPPNGNAFP PFHPGTMLDR DVGPTPMYPP TYLEPGIGRH
70 80 90 100 110 120
TPYGNQTDYR IFELNKRLQN WTEECDNLWW DAFTTEFFED DAMLTITFCL EDGPKRYTIG
130 140 150 160 170 180
RTLIPRYFRS IFEGGATELY YVLKHPKESF HNNFVSLDCD QCTMVTQHGK PMFTQVCVEG
190 200 210 220 230 240
RLYLEFMFDD MMRIKTWHFS IRQHRELIPR SILAMHAQDP QMLDQLSKNI TRCGLSNSTL
250 260 270 280 290 300
NYLRLCVILE PMQELMSRHK TYSLSPRDCL KTCLFQKWQR MVAPPAEPAR QQPSKRRKRK
310 320 330 340 350 360
MSGGSTMSSG GGNTNNSNSK KKSPASTFAL SSQVPDVMVV GEPTLMGGEF GDEDERLITR
370 380 390 400 410
LENTQFDAAN GIDDEDSFNN SPALGANSPW NSKPPSSQES KSENPTSQAS Q