Q80WP8
Gene name |
Gadl1 |
Protein name |
Acidic amino acid decarboxylase GADL1 |
Names |
Aspartate 1-decarboxylase, ADC, Cysteine sulfinic acid decarboxylase, CSADC, Glutamate decarboxylase-like protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73748 |
EC number |
4.1.1.11: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q80WP8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6ENZ | Other | 300 A | A/B | 49-550 | PDB |
| AF-Q80WP8-F1 | Predicted | AlphaFoldDB |
No variants for Q80WP8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q80WP8 | |||||
No associated diseases with Q80WP8
1 regional properties for Q80WP8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Pyridoxal-phosphate binding site | 355 - 376 | IPR021115 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.11 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartate 1-decarboxylase activity | Catalysis of the reaction: L-aspartate = beta-alanine + CO2. |
| carboxy-lyase activity | Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| sulfinoalanine decarboxylase activity | Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QM00 | GADL1 | Acidic amino acid decarboxylase GADL1 | Bos taurus (Bovine) | PR |
| Q05329 | GAD2 | Glutamate decarboxylase 2 | Homo sapiens (Human) | PR |
| Q6ZQY3 | GADL1 | Acidic amino acid decarboxylase GADL1 | Homo sapiens (Human) | PR |
| Q6ESZ9 | SDC1 | Serine decarboxylase 1 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHARDDHQG | ASQGSQWLSQ | ARTLVQEGTL | FNFIRCLLLF | QGDSGQKEMT | PGKKIPIFVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVVLNGPQTD | VKAGEKFVEE | ACRLIMEEVV | LKATDVNEKV | CEWQPPEQLR | QLLDLEMRDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GESQDKLLKL | CQDVIHFSVK | TNHPRFFNQL | YAGLDYYSLA | ARIITEALNP | SIYTYEVSPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLLVEEAVLK | KMIECVGWKE | GDGIFNPGGS | VSNMCAMNLA | RYRHCPDIKE | KGLSGLPRLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFTSAECHYS | MKKAASFLGI | GTQNVYFVET | DGRGKMIPED | LEKQIWQARQ | EGAVPFLVCA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TSGTTVLGAF | DPLDEIAEVC | ERHGLWLHVD | ASWGGSALVS | RKHRRLLHGI | HRADSVAWNP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HKMLMAGIQC | SALLVKDKSD | LLKKCYSAKA | TYLFQQDKFY | DVSYDTGDKS | IQCSRRPDAF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KFWMTWKALG | TSGLEERVNR | AFALSRYLVD | EIKKREGFKL | LMEPEYTNVC | FWYIPPSLRE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MEEGPEFWRK | LSLVAPAIKE | KMMKKGSLML | GYQPHRGKVN | FFRQVVISPQ | VSREDMDFLL |
| DEIDSLGRDM |