Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6ESZ9

Entry ID Method Resolution Chain Position Source
AF-Q6ESZ9-F1 Predicted AlphaFoldDB

No variants for Q6ESZ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6ESZ9

No associated diseases with Q6ESZ9

1 regional properties for Q6ESZ9

Type Name Position InterPro Accession
binding_site Pyridoxal-phosphate binding site 305 - 326 IPR021115

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
serine decarboxylase activity Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide.

2 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QM00 GADL1 Acidic amino acid decarboxylase GADL1 Bos taurus (Bovine) PR
Q6ZQY3 GADL1 Acidic amino acid decarboxylase GADL1 Homo sapiens (Human) PR
Q05329 GAD2 Glutamate decarboxylase 2 Homo sapiens (Human) PR
Q80WP8 Gadl1 Acidic amino acid decarboxylase GADL1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MVGSVGNGLV DLGGAAVAVN GVGKGMRPEA VAVAMEVESP PRPAEEEGEG SPTRREIVLG
70 80 90 100 110 120
RNVHTASFAV KEPDADDEET GEREAAMASV LALYRRNLVE RTKHHLGYPY NLDFDYGALG
130 140 150 160 170 180
QLQHFSINNL GDPFIESNYG VHSRQFEVGV LDWFARIWEL EKNEYWGYIT NCGTEGNLHG
190 200 210 220 230 240
ILVGREVFPD GILYASRESH YSVFKAARMY RMDCVKVDTL ISGEIDCEDF QRKLLLNRDK
250 260 270 280 290 300
PAIINVNIGT TVKGAVDDLD LVIKTLEEGG FKDRFYIHCD GALFGLMIPF VKKAPKVSFK
310 320 330 340 350 360
KPIGSVSVSG HKFVGCPMPC GVQITRLEHI NRLSSNVEYL ASRDATIMGS RNGHAPIFLW
370 380 390 400 410 420
YTLNRKGYRG FQKEVQKCLR NAHYLKDRLK EAGIGAMLNE LSSTVVFERP KDEEFVRRWQ
430 440 450 460 470 480
LACEGNIAHV VVMPSVTIDK LDYFLNELTE KRATWYQDGS CQPPCLAKDV GEENCLCSIH
KK