A6QM00

PR
Gene name
GADL1
Protein name
Acidic amino acid decarboxylase GADL1
Names
Aspartate 1-decarboxylase, ADC, Cysteine sulfinic acid decarboxylase, CSADC, Glutamate decarboxylase-like protein 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:614548
EC number
4.1.1.11: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QM00

Entry ID Method Resolution Chain Position Source
AF-A6QM00-F1 Predicted AlphaFoldDB

96 variants for A6QM00

Variant ID(s) Position Change Description Diseaes Association Provenance
rs433714659 3 L>P No EVA
rs469917800 73 E>G No EVA
rs448039361 74 W>G No EVA
rs477534025 77 P>H No EVA
rs450277852 80 L>M No EVA
rs483234423 80 L>P No EVA
rs450277852 80 L>V No EVA
rs461457308 81 K>M No EVA
rs442991609 81 K>N No EVA
rs461457308 81 K>R No EVA
rs472679747 82 R>G No EVA
rs470933502 83 L>R No EVA
rs438803627 83 L>V No EVA
rs452282163 84 L>F No EVA
rs443414199 84 L>P No EVA
rs476458067 85 D>A No EVA
rs476458067 85 D>G No EVA
rs465677014 86 L>F No EVA
rs453603174 87 E>G No EVA
rs453603174 87 E>V No EVA
rs465686414 88 L>R No EVA
rs431925230 88 L>V No EVA
rs483313432 89 R>G No EVA
rs467984440 90 D>A No EVA
rs449486488 90 D>E No EVA
rs467984440 90 D>G No EVA
rs479136188 91 A>G No EVA
rs1118132705 91 A>T No EVA
rs438842381 93 E>G No EVA
rs478215142 94 P>A No EVA
rs462953376 95 H>P No EVA
rs462953376 95 H>R No EVA
rs443535217 96 H>P No EVA
rs476526796 97 R>P No EVA
rs454603028 98 L>P No EVA
rs442547511 100 Q>P No EVA
rs472118034 101 R>L No EVA
rs876556885 102 C>* No EVA
rs431961146 102 C>F No EVA
rs453641974 102 C>R No EVA
rs876366968 103 Q>E No EVA
rs464971802 104 D>A No EVA
rs456104632 105 V>A No EVA
rs438318771 106 I>R No EVA
rs468048622 108 Y>* No EVA
rs449528109 109 S>R No EVA
rs479174828 110 V>L No EVA
rs467079424 111 K>Q No EVA
rs445402010 112 T>N No EVA
rs478338278 113 N>H No EVA
rs723478136 119 N>I No EVA
rs450777492 179 G>D No EVA
rs437929318 212 L>I No EVA
rs521541595 248 I>K No EVA
rs41991131 258 E>K No EVA
rs434748957 276 T>P No EVA
rs434748957 276 T>S No EVA
rs721629486 292 E>K No EVA
rs474466713 312 R>W No EVA
rs455833866 313 K>T No EVA
rs434103619 314 H>P No EVA
rs467006651 318 L>P No EVA
rs433110136 321 I>S No EVA
rs469201323 322 H>P No EVA
rs449941275 323 R>G No EVA
rs444798919 355 R>* No EVA
rs433474297 356 C>W No EVA
rs469658391 357 Y>* No EVA
rs451088727 361 A>G No EVA
rs480667990 388 P>R No EVA
rs462166283 399 A>D No EVA
rs446916786 406 E>Q No EVA
rs443972099 442 F>S No EVA
rs41992015 452 M>I No EVA
rs471302369 465 V>G No EVA
rs437408260 473 M>I No EVA
rs470365913 474 M>R No EVA
rs455029293 478 S>T No EVA
rs436484420 479 L>V No EVA
rs466096925 480 M>L No EVA
rs477166063 482 G>A No EVA
rs447635473 482 G>R No EVA
rs464293803 483 Y>S No EVA
rs445893897 484 Q>E No EVA
rs436229737 486 H>Y No EVA
rs482091474 487 Q>P No EVA
rs463598714 500 P>T No EVA
rs481155347 507 M>I No EVA
rs459400787 512 D>G No EVA
rs440847060 513 E>G No EVA
rs470554508 515 D>E No EVA
rs452743215 516 L>H No EVA
rs133480236 519 K>R No EVA
rs455172606 521 M>L No EVA
rs436543957 521 M>R No EVA
rs472512452 522 M>K No EVA

No associated diseases with A6QM00

1 regional properties for A6QM00

Type Name Position InterPro Accession
binding_site Pyridoxal-phosphate binding site 326 - 347 IPR021115

Functions

Description
EC Number 4.1.1.11 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
aspartate 1-decarboxylase activity Catalysis of the reaction: L-aspartate = beta-alanine + CO2.
carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
sulfinoalanine decarboxylase activity Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.

1 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05329 GAD2 Glutamate decarboxylase 2 Homo sapiens (Human) PR
Q6ZQY3 GADL1 Acidic amino acid decarboxylase GADL1 Homo sapiens (Human) PR
Q80WP8 Gadl1 Acidic amino acid decarboxylase GADL1 Mus musculus (Mouse) PR
Q6ESZ9 SDC1 Serine decarboxylase 1 Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MSLLPDRERA PDGDISPQEM VPSRKNVVLV DGVILNGPAT DVKAGEKFVE DACRLIMEEV
70 80 90 100 110 120
VLKATDINEK VCEWRPPEEL KRLLDLELRD AGEPHHRLLQ RCQDVIRYSV KTNHPRFFNQ
130 140 150 160 170 180
LYAGLDYYSL VARFMTEALN PSVYTYEVSP VFLLVEEAVL KKMIEFIGWK EGDGIFNPGG
190 200 210 220 230 240
SVSNMYAMNL ARYKYCPDIK EKGLSGLPRL ILFTSAECHY SMKKSASFLG IGTENVCFVE
250 260 270 280 290 300
TDGRGKMIPE ELEKRVQEAK KEGAAPFLVC ATSGTTVLGA FDPLDEIADI CERHGLWLHV
310 320 330 340 350 360
DASWGGSALM SRKHRRLLQG IHRADSVAWN PHKMLMAGIQ CCAFLVKDKS DLLKRCYSAN
370 380 390 400 410 420
ASYLFQQDKF YDVSYDTGDK SIQCSRRPDA FKFWLAWKAL GTLGLEERVN RALALSRYLV
430 440 450 460 470 480
EEIKKREGFK LLMEPEYANI CFWYIPPSLR QMEEGPEFWA KLHLVAPAIK ERMMKKGSLM
490 500 510 520
LGYQPHQGKV NFFRQVVISP QVSREDMDFL LDEIDLLGKD M