AiPD: Autoinhibited Protein Database

Q7Z2W9

Gene name	MRPL21
Protein name	39S ribosomal protein L21, mitochondrial
Names	L21mt, MRP-L21, Mitochondrial large ribosomal subunit protein bL21m
Species	Homo sapiens (Human)
KEGG Pathway	hsa:219927
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-119 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

61 structures for Q7Z2W9

Entry ID	Method	Resolution	Chain	Position	Source
3J7Y	EM	340 A	S	1-205	PDB
3J9M	EM	350 A	S	1-205	PDB
5OOL	EM	306 A	S	1-205	PDB
5OOM	EM	303 A	S	1-205	PDB
6I9R	EM	390 A	S	1-205	PDB
6NU2	EM	390 A	S	49-204	PDB
6NU3	EM	440 A	S	1-205	PDB
6VLZ	EM	297 A	S	1-205	PDB
6VMI	EM	296 A	S	1-205	PDB
6ZM5	EM	289 A	S	1-205	PDB
6ZM6	EM	259 A	S	1-205	PDB
6ZS9	EM	400 A	XS	1-205	PDB
6ZSA	EM	400 A	XS	1-205	PDB
6ZSB	EM	450 A	XS	1-205	PDB
6ZSC	EM	350 A	XS	1-205	PDB
6ZSD	EM	370 A	XS	1-205	PDB
6ZSE	EM	500 A	XS	1-205	PDB
6ZSG	EM	400 A	XS	1-205	PDB
7A5F	EM	440 A	S3	1-205	PDB
7A5G	EM	433 A	S3	1-205	PDB
7A5H	EM	330 A	S	1-205	PDB
7A5I	EM	370 A	S3	1-205	PDB
7A5J	EM	310 A	S	1-205	PDB
7A5K	EM	370 A	S3	1-205	PDB
7L08	EM	349 A	S	1-205	PDB
7L20	EM	315 A	S	1-205	PDB
7O9K	EM	310 A	S	1-205	PDB
7O9M	EM	250 A	S	1-205	PDB
7ODR	EM	290 A	S	1-205	PDB
7ODS	EM	310 A	S	1-205	PDB
7ODT	EM	310 A	S	1-205	PDB
7OF0	EM	220 A	S	1-205	PDB
7OF2	EM	270 A	S	1-205	PDB
7OF3	EM	270 A	S	1-205	PDB
7OF4	EM	270 A	S	1-205	PDB
7OF5	EM	290 A	S	1-205	PDB
7OF6	EM	260 A	S	1-205	PDB
7OF7	EM	250 A	S	1-205	PDB
7OG4	EM	380 A	XS	1-205	PDB
7OI6	EM	570 A	S	1-205	PDB
7OI7	EM	350 A	S	1-205	PDB
7OI8	EM	350 A	S	1-205	PDB
7OI9	EM	330 A	S	1-205	PDB
7OIA	EM	320 A	S	1-205	PDB
7OIB	EM	330 A	S	1-205	PDB
7OIC	EM	310 A	S	1-205	PDB
7OID	EM	370 A	S	1-205	PDB
7OIE	EM	350 A	S	1-205	PDB
7PD3	EM	340 A	S	1-205	PDB
7PO4	EM	256 A	S	1-205	PDB
7QH6	EM	308 A	S	1-205	PDB
7QH7	EM	289 A	S	49-204	PDB
7QI4	EM	221 A	S	1-205	PDB
7QI5	EM	263 A	S	1-205	PDB
7QI6	EM	298 A	S	1-205	PDB
8ANY	EM	285 A	S	1-205	PDB
8OIR	EM	310 A	BZ	1-205	PDB
8OIT	EM	290 A	BZ	1-205	PDB
8PK0	EM	303 A	S	1-205	PDB
8QSJ	EM	300 A	S	1-205	PDB
AF-Q7Z2W9-F1	Predicted				AlphaFoldDB

189 variants for Q7Z2W9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1193657115 CA381641108	2	A>V		No	ClinGen gnomAD
rs1288663243 CA381641097	3	A>V		No	ClinGen gnomAD
rs764142098 CA6153106	4	S>F		No	ClinGen ExAC gnomAD
CA223381399 rs1016987919	5	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA381641064 rs765147530	7	T>A		No	ClinGen ExAC gnomAD
CA381641057 rs553560241	7	T>M		No	ClinGen gnomAD
CA6153102 rs765147530	7	T>P		No	ClinGen ExAC gnomAD
CA223381369 rs553560241	7	T>R		No	ClinGen gnomAD
CA223381356 rs933595985	8	V>D		No	ClinGen TOPMed
rs1344197380 CA381641053	8	V>F		No	ClinGen TOPMed
CA6153098 rs200690672	9	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA381641038 rs200690672	9	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6153099 rs570879590	9	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1022959231 CA223381307	10	L>*		No	ClinGen TOPMed gnomAD
CA381641027 rs1022959231	10	L>S		No	ClinGen TOPMed gnomAD
CA381641011 rs1477151342	12	R>W		No	ClinGen gnomAD
CA381640998 rs1266013993	13	L>P		No	ClinGen gnomAD
rs1594411495 CA381640963	17	C>G		No	ClinGen Ensembl
rs774637204 CA6153094	17	C>S		No	ClinGen ExAC gnomAD
CA223381291 rs749609896	18	S>R		No	ClinGen Ensembl
rs1168051714 CA381640931	19	H>Y		No	ClinGen TOPMed gnomAD
CA381640911 rs1448204668	20	S>N		No	ClinGen TOPMed
rs769010155 CA6153093	21	I>M		No	ClinGen ExAC gnomAD
CA381640879 rs1168518857	22	L>P		No	ClinGen TOPMed
CA381640856 rs1448251563	24	P>L		No	ClinGen Ensembl
rs374343543 CA6153092	24	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs138824749 CA6153091	25	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769739650 CA6153090	27	P>L		No	ClinGen ExAC
rs1315478106 CA381640830	27	P>T		No	ClinGen TOPMed gnomAD
rs896386997 CA381640817	28	G>A		No	ClinGen TOPMed
CA223381234 rs896386997	28	G>E		No	ClinGen TOPMed
rs149488370 CA6153089	28	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1320965412 CA381640813	29	A>T		No	ClinGen TOPMed
rs1216118522 CA381640250	32	L>F		No	ClinGen TOPMed
rs541342052 CA6153070	35	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6153071 rs541342052	35	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs137864766 CA6153068	37	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs137864766 CA381640221	37	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs146932385 CA381640220	37	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs146932385 CA6153067	37	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs754802573 CA6153066	38	R>G		No	ClinGen ExAC TOPMed gnomAD
CA381640206 rs376576401	39	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs753712080 CA6153065	39	F>V		No	ClinGen ExAC gnomAD
CA6153063 rs755730762	40	N>D		No	ClinGen ExAC gnomAD
CA6153062 rs750045430	40	N>S		No	ClinGen ExAC gnomAD
rs1239514766 CA381640193	42	Q>*		No	ClinGen TOPMed gnomAD
CA6153061 rs767047685	42	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1482621381 CA381640183	43	S>N		No	ClinGen gnomAD
CA6153060 rs756815802	45	S>L		No	ClinGen ExAC gnomAD
CA6153059 rs752038568	46	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA381640166 rs1289582426	46	Y>H		No	ClinGen TOPMed
rs763482916 CA6153057	49	G>E		No	ClinGen ExAC TOPMed gnomAD
rs767865918 CA6153032	50	Y>*		No	ClinGen ExAC TOPMed
CA6153034 rs371118102	50	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs147848594 CA6153030	52	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6153031 rs773363270	52	P>T		No	ClinGen ExAC gnomAD
CA223375818 rs1012846406	54	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA381640105 rs1336580784	54	T>I		No	ClinGen TOPMed
rs1241617344 CA381640097	56	L>V		No	ClinGen TOPMed
rs1313700004 CA381640081	58	S>L		No	ClinGen gnomAD
CA6153027 rs769601533	59	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1350556027 CA381640070	60	P>R		No	ClinGen TOPMed
rs745700362 CA6153026	61	W>*		No	ClinGen ExAC TOPMed gnomAD
CA381640067 rs1262157252	61	W>R		No	ClinGen gnomAD
CA6153025 rs148367955	64	V>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6153024 rs747939629	68	D>Y		No	ClinGen ExAC gnomAD
CA6153023 rs746668276	69	P>A		No	ClinGen ExAC TOPMed gnomAD
CA381640015 rs1402327414	69	P>Q		No	ClinGen gnomAD
CA6153022 rs777206792	72	E>D		No	ClinGen ExAC TOPMed gnomAD
CA381639987 rs1385914356	73	T>I		No	ClinGen gnomAD
rs371624461 CA223375795	73	T>P		No	ClinGen TOPMed
rs371624461 CA381639990	73	T>S		No	ClinGen TOPMed
CA381639984 rs368027804	74	R>K		No	ClinGen ExAC TOPMed gnomAD
rs368027804 CA6153020	74	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1341918165 CA381639974	75	H>Q		No	ClinGen Ensembl
rs1177004716 CA381639968	76	H>R		No	ClinGen TOPMed
CA223375791 rs1006140882	77	A>T		No	ClinGen TOPMed
CA381639944 rs1347658916	78	E>G		No	ClinGen TOPMed gnomAD
TCGA novel	80	V>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140815939 CA6152992	80	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764238493 CA6152991	82	K>M		No	ClinGen ExAC TOPMed gnomAD
CA6152990 rs759410925	83	V>L		No	ClinGen ExAC gnomAD
CA223374725 rs1013100011	85	E>A		No	ClinGen TOPMed gnomAD
CA6152987 rs760500617	88	V>I		No	ClinGen ExAC TOPMed gnomAD
rs772825939 CA6152986	89	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6152985 rs150988778	89	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768274589 CA6152982	90	G>E		No	ClinGen ExAC gnomAD
CA6152983 rs200445060	90	G>W		No	ClinGen ExAC TOPMed gnomAD
rs764557428 CA223374681	93	G>A		No	ClinGen Ensembl
TCGA novel	93	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6152979 rs756526515	93	G>S		No	ClinGen ExAC gnomAD
rs746187003 CA6152978	95	L>P		No	ClinGen ExAC TOPMed gnomAD
CA381639838 rs1486930542	95	L>V		No	ClinGen gnomAD
rs1566415792 CA381639825	97	A>T		No	ClinGen Ensembl
CA6152976 rs757355551	98	V>M		No	ClinGen ExAC TOPMed gnomAD
rs751820032 CA6152975	99	V>A		No	ClinGen ExAC gnomAD
rs751820032 CA381639810	99	V>G		No	ClinGen ExAC gnomAD
TCGA novel	100	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA381639806 rs1594405348	100	H>P		No	ClinGen Ensembl
CA381639794 rs1225047141	101	F>L		No	ClinGen gnomAD
rs764066653 CA6152974	102	A>T		No	ClinGen ExAC gnomAD
rs564042523 CA6152972	104	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148535951 COSM245773 CA6152971	104	R>H	lung prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA381639765 rs1399177148	106	W>*		No	ClinGen gnomAD
CA381639746 rs1358314498	108	V>G		No	ClinGen gnomAD
CA381639751 rs1456010809	108	V>M		No	ClinGen gnomAD
CA6152968 rs578139438	114	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA6152967 rs553569438	116	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6152965 rs768253705	121	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs372240224 CA6152964	123	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA381639617 rs1566415696	128	I>F		No	ClinGen Ensembl
CA223374612 COSM2043062 rs992841927	129	R>*	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs143584803 CA6152961	129	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs746382949 CA6152960	130	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1375362651 CA381639608	130	L>Q		No	ClinGen gnomAD
rs1594405221 CA381639591	132	K>N		No	ClinGen Ensembl
CA6152959 rs781353875	132	K>R		No	ClinGen ExAC gnomAD
rs1332146727 CA381639568	135	L>M		No	ClinGen TOPMed gnomAD
rs1332146727 CA381639569	135	L>V		No	ClinGen TOPMed gnomAD
CA6152940 rs373658531	136	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6152939 rs373658531	136	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA6152938 rs772240021	138	A>T		No	ClinGen ExAC gnomAD
CA381639544 rs1330737365	139	D>E		No	ClinGen gnomAD
rs748370669 CA6152937	139	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs778903810 CA6152936	140	N>D		No	ClinGen ExAC TOPMed gnomAD
rs755121519 CA381639537	140	N>K		No	ClinGen ExAC gnomAD
CA381639540 rs1356813251	140	N>S		No	ClinGen TOPMed gnomAD
COSM1298528 rs750300527 CA6152934	141	F>L	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs750300527 CA223372996	141	F>V		No	ClinGen ExAC gnomAD
CA6152932 rs757166826 COSM297129	142	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6152933 rs781241516	142	T>P		No	ClinGen ExAC
CA6152928 rs752456287	144	L>F		No	ClinGen ExAC
rs752456287 CA6152929	144	L>I		No	ClinGen ExAC
CA6152925 rs771419233	145	G>A		No	ClinGen ExAC gnomAD
CA6152924 rs771419233	145	G>D		No	ClinGen ExAC gnomAD
CA223372961 rs1024986320	146	K>E		No	ClinGen Ensembl
CA6152922 rs773495806	146	K>T		No	ClinGen ExAC gnomAD
rs772435666 CA6152920	147	P>Q		No	ClinGen ExAC gnomAD
TCGA novel	147	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370223908	149	L>=	Variant assessed as Somatic; 0.000231 impact. [NCI-TCGA]	No	NCI-TCGA
CA381639495 rs1277909402	149	L>V		No	ClinGen gnomAD
CA6152917 rs768600289	150	G>R		No	ClinGen ExAC gnomAD
TCGA novel	151	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773763327 CA223372772	152	D>G		No	ClinGen ExAC gnomAD
rs773763327 CA6152904	152	D>V		No	ClinGen ExAC gnomAD
rs1594402703 CA381639451	154	V>F		No	ClinGen Ensembl
rs374183424 CA6152902	155	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA381639447 rs374183424	155	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6152900 rs371171289	155	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371171289 CA6152901	155	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA381639444 rs1256468753	156	V>I		No	ClinGen TOPMed
CA223372760 rs887434660	157	E>K		No	ClinGen TOPMed gnomAD
CA381639425 rs1214752755	159	T>A		No	ClinGen TOPMed
rs749477981 CA6152899	159	T>I		No	ClinGen ExAC gnomAD
CA6152898 rs775584446	161	I>T		No	ClinGen ExAC gnomAD
CA381639414 rs1360218197	161	I>V		No	ClinGen TOPMed gnomAD
CA381639383 rs746939119	165	E>A		No	ClinGen ExAC gnomAD
CA381639387 rs1365088180	165	E>K		No	ClinGen gnomAD
CA6152896 rs746939119	165	E>V		No	ClinGen ExAC gnomAD
TCGA novel	166	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747901180 CA6152893	167	W>*		No	ClinGen ExAC gnomAD
rs528356268 CA6152894	167	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA223372729 rs770518415	172	M>K		No	ClinGen gnomAD
CA381639337 rs770518415	172	M>T		No	ClinGen gnomAD
CA223372732 rs865881697	172	M>V		No	ClinGen TOPMed gnomAD
rs199675137 CA6152892	173	R>K		No	ClinGen ExAC TOPMed gnomAD
CA381639315 rs1262185612	175	R>K		No	ClinGen gnomAD
CA381639301 rs1203659803	177	R>K		No	ClinGen gnomAD
rs1244182671 CA381639275	180	F>L		No	ClinGen gnomAD
CA381639264 rs1332698133	182	K>E		No	ClinGen gnomAD
rs140044531 CA6152891	183	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs35283923 CA6152834	186	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs986218392 CA223372041	187	T>M		No	ClinGen Ensembl
rs762955978 CA6152832	188	T>I		No	ClinGen ExAC gnomAD
CA381638634 rs1265903244	189	P>L		No	ClinGen gnomAD
CA6152831 rs775093931	189	P>S		No	ClinGen ExAC gnomAD
CA381638613 rs1346559514	193	L>F		No	ClinGen TOPMed
rs201987235 CA223372026	194	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6152829 rs745515841	194	R>W		No	ClinGen ExAC gnomAD
rs971909311 CA223372015	195	I>R		No	ClinGen Ensembl
CA6152828 rs780865180	197	S>T		No	ClinGen ExAC gnomAD
CA6152826 rs200169733	199	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1370409159 CA381638561	201	A>P		No	ClinGen TOPMed gnomAD
CA381638560 rs1370409159	201	A>T		No	ClinGen TOPMed gnomAD
rs758764572 CA6152824	202	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6152825 rs375095771	202	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs139341584 CA6152822	203	C>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6152819 rs766753927	206	L>R		No	ClinGen ExAC gnomAD
CA6152817 rs750406393	206	L>W		No	ClinGen ExAC gnomAD

No associated diseases with Q7Z2W9

No regional properties for Q7Z2W9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q7Z2W9

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit	The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40858	MRPL49	54S ribosomal protein L49, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9D1N9	Mrpl21	39S ribosomal protein L21, mitochondrial	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAASSLTVTL	GRLASACSHS	ILRPSGPGAA	SLWSASRRFN	SQSTSYLPGY	VPKTSLSSPP
70	80	90	100	110	120
WPEVVLPDPV	EETRHHAEVV	KKVNEMIVTG	QYGRLFAVVH	FASRQWKVTS	EDLILIGNEL
130	140	150	160	170	180
DLACGERIRL	EKVLLVGADN	FTLLGKPLLG	KDLVRVEATV	IEKTESWPRI	IMRFRKRKNF
190	200
KKKRIVTTPQ	TVLRINSIEI	APCLL