P40858

PR
Gene name
MRPL49 (YJL096W, J0904)
Protein name
54S ribosomal protein L49, mitochondrial
Names
Mitochondrial large ribosomal subunit protein bL21m, YmL49
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL096W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P40858

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A N 1-161 PDB
5MRC EM 325 A N 44-161 PDB
5MRE EM 375 A N 44-161 PDB
5MRF EM 497 A N 44-161 PDB
AF-P40858-F1 Predicted AlphaFoldDB

2 variants for P40858

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-246610 42 T>S No SGRP
s10-246774 97 L>V No SGRP

No associated diseases with P40858

No regional properties for P40858

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P40858

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z2W9 MRPL21 39S ribosomal protein L21, mitochondrial Homo sapiens (Human) PR
Q9D1N9 Mrpl21 39S ribosomal protein L21, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MLQLKFIWPV ARITPIYRPF TSHPFRNLAT SSSISSTKAK TTKTDTTPLK LSNELYAIFK
70 80 90 100 110 120
IHNRPYLVTE GDRVILPFKL KQAEVGDILN MTDVTTLGSR NYKLVGHPIN TSLYTLKATV
130 140 150 160
VGKTKRAFQT REVTKRRNRR VRHAKSKGDL TILRISELSM N