Q7TQD2

PR
Gene name
Tppp
Protein name
Tubulin polymerization-promoting protein
Names
TPPP, 25 kDa brain-specific protein, TPPP/p25, p25-alpha
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72948
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7TQD2

Entry ID Method Resolution Chain Position Source
AF-Q7TQD2-F1 Predicted AlphaFoldDB

15 variants for Q7TQD2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3404656654 44 A>S No EVA
rs3389289144 74 N>I No EVA
rs3389295779 85 I>N No EVA
rs3389309181 90 V>M No EVA
rs3389276707 103 K>E No EVA
rs3389219881 113 E>K No EVA
rs3389250604 116 Q>L No EVA
rs3389258727 144 E>* No EVA
rs3389295621 167 D>H No EVA
rs3389285718 170 K>N No EVA
rs3389276615 178 R>H No EVA
rs3389267894 180 D>V No EVA
rs3389304600 187 G>R No EVA
rs3389258708 194 L>Q No EVA
rs3389258721 197 E>K No EVA

No associated diseases with Q7TQD2

No regional properties for Q7TQD2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q7TQD2

Functions

Description
EC Number
Subcellular Localization
  • Golgi outpost
  • Cytoplasm, cytoskeleton, microtubule organizing center
  • Cytoplasm, cytoskeleton
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity)
  • Mainly localizes to the cytoskeleton (PubMed:18028908)
  • Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908)
  • Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies
  • During mitosis, colocalizes with LIMK2 at the mitotic spindle (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule bundle An arrangement of closely apposed microtubules running parallel to each other.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
postsynaptic Golgi apparatus The network of the Golgi apparatus structures located within the postsynapse.

5 GO annotations of molecular function

Name Definition
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein homodimerization activity Binding to an identical protein to form a homodimer.
tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules.

13 GO annotations of biological process

Name Definition
astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
microtubule bundle formation A process that results in a parallel arrangement of microtubules.
microtubule nucleation by microtubule organizing center The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.
microtubule polymerization The addition of tubulin heterodimers to one or both ends of a microtubule.
myelin assembly The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.
negative regulation of tubulin deacetylation Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
positive regulation of myelination Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
positive regulation of protein polymerization Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27957 TPPP Tubulin polymerization-promoting protein Bos taurus (Bovine) PR
O94811 TPPP Tubulin polymerization-promoting protein Homo sapiens (Human) PR
10 20 30 40 50 60
MADSKAKPAK AANKTPPKSP GDPARAAKRL SLESEGANEG ATAAPELSAL EEAFRRFAVH
70 80 90 100 110 120
GDTRATGKEM HGKNWSKLCK DCHVIDGKNV TVTDVDIVFS KIKGKSCRTI TFEQFQEALE
130 140 150 160 170 180
ELAKKRFKDK SSEEAVREVH RLIEGRAPVI SGVTKAVSSP TVSRLTDTSK FTGSHKERFD
190 200 210
QSGKGKGKAG RVDLVDESGY VPGYKHAGTY DQKVQGGK