Q27957

PR
Gene name
TPPP
Protein name
Tubulin polymerization-promoting protein
Names
TPPP, 25 kDa brain-specific protein, p25-alpha
Species
Bos taurus (Bovine)
KEGG Pathway
bta:280968
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q27957

Entry ID Method Resolution Chain Position Source
AF-Q27957-F1 Predicted AlphaFoldDB

131 variants for Q27957

Variant ID(s) Position Change Description Diseaes Association Provenance
rs441146081 2 A>G No EVA
rs460062993 2 A>P No EVA
rs462180032 3 D>A No EVA
rs443725274 3 D>E No EVA
rs476726039 4 S>G No EVA
rs451365329 4 S>I No EVA
rs432984241 4 S>R No EVA
rs451365329 4 S>T No EVA
rs472439334 5 R>G No EVA
rs453997031 5 R>M No EVA
rs435497653 5 R>S No EVA
rs437630692 7 K>N No EVA
rs449621050 7 K>R No EVA
rs464282056 8 P>A No EVA
rs464282056 8 P>T No EVA
rs445353068 9 A>P No EVA
rs445353068 9 A>S No EVA
rs478456948 9 A>V No EVA
rs459941945 10 N>K No EVA
rs480946680 12 T>M No EVA
rs447975156 12 T>P No EVA
rs447975156 12 T>S No EVA
rs458252829 15 K>Q No EVA
rs439338604 16 S>A No EVA
rs439338604 16 S>P No EVA
rs439338604 16 S>T No EVA
rs472421540 17 P>R No EVA
rs455944344 19 E>D No EVA
rs441845459 19 E>K No EVA
rs474732275 19 E>V No EVA
rs437568403 23 D>E No EVA
rs464178506 24 K>E No EVA
rs464178506 24 K>Q No EVA
rs452178507 25 A>G No EVA
rs466367071 28 R>G No EVA
rs480885040 30 S>* No EVA
rs447913653 30 S>A No EVA
rs480885040 30 S>W No EVA
rs468885336 31 L>P No EVA
rs483069930 32 E>A No EVA
rs483069930 32 E>G No EVA
rs460149591 38 E>G No EVA
rs441785886 42 A>E No EVA
rs474671039 43 A>P No EVA
rs474671039 43 A>T No EVA
rs444346769 45 A>G No EVA
rs452043735 46 E>G No EVA
rs466646534 47 L>Q No EVA
rs435786621 48 S>R No EVA
rs468821979 49 A>G No EVA
rs483348493 50 L>P No EVA
rs464543896 51 E>A No EVA
rs464543896 51 E>G No EVA
rs479122623 52 E>D No EVA
rs446018707 52 E>G No EVA
rs448147012 53 A>G No EVA
rs460491386 53 A>P No EVA
rs481019703 54 F>L No EVA
rs462626612 55 R>G No EVA
rs444304064 59 V>G No EVA
rs458520095 60 H>D No EVA
rs440006458 60 H>P No EVA
rs473094171 61 G>R No EVA
rs454626807 62 D>A No EVA
rs436121916 66 S>A No EVA
rs475189527 73 K>T No EVA
rs456757359 74 N>H No EVA
rs438258611 86 D>A No EVA
rs134935402 89 S>G No EVA
rs132791987 91 T>P No EVA
rs464840877 92 V>G No EVA
rs433979546 94 D>H No EVA
rs448486661 96 D>A No EVA
rs462561031 101 K>Q No EVA
rs466475702 105 K>N No EVA
rs447633050 107 C>G No EVA
rs480609964 108 R>T No EVA
rs443701515 112 F>I No EVA
rs483209911 116 K>Q No EVA
rs439402018 129 D>G No EVA
rs472258824 133 E>V No EVA
rs453877706 139 V>G No EVA
rs474396316 148 P>H No EVA
rs456097660 149 I>S No EVA
rs437665897 150 I>V No EVA
rs470690682 153 V>G No EVA
rs464503414 157 I>F No EVA
rs464503414 157 I>L No EVA
rs452414082 157 I>T No EVA
rs466914074 158 S>P No EVA
rs448147138 159 S>P No EVA
rs469241680 161 T>P No EVA
rs458499224 165 L>P No EVA
rs479465079 166 T>P No EVA
rs442552922 167 D>G No EVA
rs461046650 167 D>H No EVA
rs475193179 168 T>P No EVA
rs475193179 168 T>S No EVA
rs456748128 169 S>I No EVA
rs444665154 171 F>Y No EVA
rs471125770 172 T>P No EVA
rs433959310 174 S>C No EVA
rs466852710 177 E>Q No EVA
rs454864816 182 S>P No EVA
rs469128272 184 R>G No EVA
rs450686648 184 R>M No EVA
rs477310387 184 R>S No EVA
rs450686648 184 R>T No EVA
rs446410501 185 G>A No EVA
rs465272964 185 G>S No EVA
rs460977275 188 R>G No EVA
rs481991137 196 D>G No EVA
rs463079073 201 V>G No EVA
rs440702889 204 Y>* No EVA
rs459081700 204 Y>D No EVA
rs473187956 205 K>* No EVA
rs454945578 206 H>N No EVA
rs457035637 207 A>E No EVA
rs457035637 207 A>G No EVA
rs475966039 207 A>T No EVA
rs457035637 207 A>V No EVA
rs465209904 209 T>S No EVA
rs434700297 210 Y>C No EVA
rs446748654 210 Y>N No EVA
rs467340882 213 K>E No EVA
rs481936335 213 K>N No EVA
rs448883825 213 K>R No EVA
rs517585589 215 Q>H No EVA
rs463469900 216 G>E No EVA
rs444943745 217 G>C No EVA
rs459012879 218 K>E No EVA

No associated diseases with Q27957

No regional properties for Q27957

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q27957

Functions

Description
EC Number
Subcellular Localization
  • Golgi outpost
  • Cytoplasm, cytoskeleton, microtubule organizing center
  • Cytoplasm, cytoskeleton
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity)
  • Mainly localizes to the cytoskeleton
  • Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences
  • Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies
  • During mitosis, colocalizes with LIMK2 at the mitotic spindle (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
postsynaptic Golgi apparatus The network of the Golgi apparatus structures located within the postsynapse.

5 GO annotations of molecular function

Name Definition
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein homodimerization activity Binding to an identical protein to form a homodimer.
tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules.

13 GO annotations of biological process

Name Definition
astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
microtubule bundle formation A process that results in a parallel arrangement of microtubules.
microtubule nucleation by microtubule organizing center The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.
microtubule polymerization The addition of tubulin heterodimers to one or both ends of a microtubule.
myelin assembly The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.
negative regulation of tubulin deacetylation Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
positive regulation of myelination Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
positive regulation of protein polymerization Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O94811 TPPP Tubulin polymerization-promoting protein Homo sapiens (Human) PR
Q7TQD2 Tppp Tubulin polymerization-promoting protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MADSRPKPAN KTPPKSPGEP AKDKAAKRLS LEAEGAGEGA AAAGAELSAL EEAFRKFAVH
70 80 90 100 110 120
GDARASGREM HGKNWSKLCR DCQVIDGRSV TVTDVDIVFS KIKGKSCRTI TFEQFKEALE
130 140 150 160 170 180
ELAKKRFKDK SAEEAVREVH KLIEGKAPII SGVTKAISSP TVSRLTDTSK FTGSHKERFD
190 200 210
PSGRGKGRAG RVDLVDESGY VPGYKHAGTY DQKVQGGK