AiPD: Autoinhibited Protein Database

O94811

Gene name	TPPP
Protein name	Tubulin polymerization-promoting protein
Names	TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11076
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-74 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O94811

Entry ID	Method	Resolution	Chain	Position	Source
AF-O94811-F1	Predicted				AlphaFoldDB

196 variants for O94811

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3177480 rs746467325	2	A>V		No	ClinGen ExAC TOPMed gnomAD
rs62330308 CA112854032	5	A>D		No	ClinGen Ensembl
CA359041032 rs1414256346	6	K>N		No	ClinGen TOPMed gnomAD
CA3177479 rs779430730	6	K>Q		No	ClinGen ExAC gnomAD
rs1561089461 CA359040979	9	K>N		No	ClinGen Ensembl
rs1169389134 CA359040973	10	A>T		No	ClinGen gnomAD
rs750125717 CA3177477	12	N>K		No	ClinGen ExAC TOPMed gnomAD
CA3177476 rs765035106	13	R>G		No	ClinGen ExAC TOPMed gnomAD
rs536441219 CA3177475	13	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754225798 CA3177474	14	T>M		No	ClinGen ExAC TOPMed gnomAD
CA359040885 rs1235945329	15	P>L		No	ClinGen gnomAD
rs761102203 CA3177472	15	P>S		No	ClinGen ExAC gnomAD
CA359040875 rs1441579544	16	P>S		No	ClinGen TOPMed gnomAD
rs759660370 CA3177468	19	P>L		No	ClinGen ExAC TOPMed gnomAD
rs771208038 CA3177466	20	G>R		No	ClinGen ExAC gnomAD
rs1326647609 CA359040764	22	P>S		No	ClinGen TOPMed
CA3177463 rs375949324	23	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3177464 rs538571986	23	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs779571406 CA3177461	25	D>H		No	ClinGen ExAC TOPMed gnomAD
CA3177459 rs371401446	26	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA3177460 rs757964583	26	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1166376461 CA359040665	27	A>E		No	ClinGen gnomAD
rs1166376461 CA359040671	27	A>V		No	ClinGen gnomAD
TCGA novel	28	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3177458 rs570878136 COSM1132129	30	R>K	prostate [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA359040611 rs570878136	30	R>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757029406 CA3177457	31	L>V		No	ClinGen ExAC gnomAD
rs754176094 CA3177456	32	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA359040552 rs1187127409	34	E>Q		No	ClinGen TOPMed
rs370108467 CA359040522	35	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs370108467 CA3177450	35	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs759605283 CA3177451	35	S>T		No	ClinGen ExAC gnomAD
rs370108467 CA359040519	35	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1455635672 CA359040487	37	G>A		No	ClinGen TOPMed
rs1287169458 CA359040492	37	G>S		No	ClinGen gnomAD
CA3177447 rs776442248	38	A>V		No	ClinGen ExAC TOPMed gnomAD
CA112853849 rs386684289	39	G>A		No	ClinGen Ensembl
rs61731452 CA3177443 RCV000946828	39	G>A		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs151029018 CA3177445	39	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61731452 CA3177444	39	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359040434 rs1332176157	40	E>V		No	ClinGen gnomAD
CA359040407 rs1327091842	41	G>V		No	ClinGen gnomAD
CA3177442 rs745360667	42	A>P		No	ClinGen ExAC gnomAD
TCGA novel	42	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1323001547 CA359040392	42	A>V		No	ClinGen gnomAD
CA112853828 rs61731453	43	A>S		No	ClinGen Ensembl
rs770643131 CA3177440	44	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1447420944 CA359040320	46	P>H		No	ClinGen gnomAD
rs1397265561 CA359040279	48	L>P		No	ClinGen gnomAD
CA359040271 rs1489435847	49	S>I		No	ClinGen gnomAD
CA3177439 rs748925097	50	A>T		No	ClinGen ExAC TOPMed gnomAD
CA359040246 COSM1438515 rs1220144619	50	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	52	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200264279 CA3177437	53	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1047173226 CA112853796	53	E>G		No	ClinGen TOPMed gnomAD
CA3177438 COSM1695331 rs778150992	53	E>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA112853780 rs370031409	54	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA3177436 rs370031409	54	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs528458616 CA3177434	56	R>G		No	ClinGen ExAC TOPMed gnomAD
rs751569987 CA3177433	56	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs528458616 CA3177435	56	R>W		No	ClinGen ExAC TOPMed gnomAD
CA3177432 rs377528137	57	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA112853749 rs920050237	57	R>H		No	ClinGen TOPMed gnomAD
rs868224748 CA112853739	59	A>V		No	ClinGen Ensembl
CA112853720 rs147824661	60	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3177429 rs147824661	60	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs772078187 CA3177426 CA359040051	62	G>R		No	ClinGen ExAC TOPMed gnomAD
CA3177425 rs200010438	63	D>V		No	ClinGen ExAC TOPMed gnomAD
CA359040002 rs144404274	64	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144404274 CA3177423	64	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs142104899 CA3177420	68	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359039937 rs142104899	68	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3177416 rs535424103	71	M>I		No	ClinGen ExAC gnomAD
rs1301173646 CA359039869	72	H>D		No	ClinGen gnomAD
rs780583434 CA359039846 CA112853623	72	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1301173646 CA359039868	72	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs758380811 CA3177414	73	G>S		No	ClinGen ExAC TOPMed gnomAD
rs750587089 CA3177413	77	S>L		No	ClinGen ExAC TOPMed gnomAD
CA112853601 rs750587089	77	S>W		No	ClinGen ExAC TOPMed gnomAD
CA3177411 rs757517768	79	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	83	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA359039519 rs1434933315	85	V>M		No	ClinGen TOPMed
CA359039470 rs1467375576	87	D>H		No	ClinGen TOPMed gnomAD
CA359039473 rs1467375576	87	D>N		No	ClinGen TOPMed gnomAD
CA3177408 rs759499130	88	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1413473902 CA359039427	89	R>K		No	ClinGen gnomAD
CA359039379 rs1305624596	91	V>M		No	ClinGen gnomAD
CA3177405 rs762357148	92	T>N		No	ClinGen ExAC gnomAD
CA3177402 rs371009510	93	V>I		No	ClinGen ExAC TOPMed gnomAD
CA112853581 rs893812212	98	I>V		No	ClinGen TOPMed
CA3177399 rs374117987	99	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA112853561 rs1038490634	101	S>R		No	ClinGen TOPMed
rs924093775 CA112853553	102	K>E		No	ClinGen TOPMed gnomAD
rs1191730630 CA359039102	103	I>V		No	ClinGen TOPMed
rs1473908818 CA359035666	105	G>R		No	ClinGen gnomAD
CA359035645 rs1580072668	106	K>M		No	ClinGen Ensembl
CA3177319 rs768821190	109	R>L		No	ClinGen ExAC gnomAD
rs768821190 CA3177318	109	R>Q		No	ClinGen ExAC gnomAD
rs748214010 CA3177320	109	R>W		No	ClinGen ExAC gnomAD
CA359035575 rs745621126	110	T>I		No	ClinGen ExAC TOPMed gnomAD
CA3177317 rs745621126	110	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1282985175 CA359035521	115	Q>E		No	ClinGen gnomAD
rs1330708729 CA359035490	117	Q>R		No	ClinGen gnomAD
rs749246726 CA3177314	119	A>G		No	ClinGen ExAC gnomAD
rs749246726 CA359035465	119	A>V		No	ClinGen ExAC gnomAD
CA3177312 rs755620478	120	L>M		No	ClinGen ExAC gnomAD
rs569786637 CA112835606	124	A>T		No	ClinGen TOPMed
CA3177310 rs767137996	126	K>E		No	ClinGen ExAC gnomAD
rs754589560 CA3177309	127	R>*		No	ClinGen ExAC gnomAD
CA359035383 rs751932777	127	R>L		No	ClinGen ExAC gnomAD
CA3177308 rs751932777	127	R>Q		No	ClinGen ExAC gnomAD
rs139049812 CA112835599	130	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1018122715	130	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139049812 CA3177307	130	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs763456851 CA3177306	131	K>E		No	ClinGen ExAC gnomAD
CA3177303 rs150708894	132	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA3177302 rs761937617	132	S>R		No	ClinGen ExAC gnomAD
rs370610823 CA359035312	133	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs775980060 CA3177300	134	E>K		No	ClinGen ExAC TOPMed gnomAD
CA3177299 rs775980060	134	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1474399057 CA359035295	135	E>A		No	ClinGen TOPMed gnomAD
CA359035298 rs1190393182	135	E>K		No	ClinGen gnomAD
rs1474399057 CA359035292	135	E>V		No	ClinGen TOPMed gnomAD
CA3177296 rs749121992	137	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200582979 CA3177295	138	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs200582979 CA359035273	138	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs371896286 CA3177294	138	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs371896286 CA112835543	138	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs142977897 CA3177292	139	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs747626300 CA3177293	139	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1201662379 CA359035263	140	V>L		No	ClinGen TOPMed
rs1048417660 CA359035235	144	I>F		No	ClinGen TOPMed gnomAD
rs1580072378 CA359035233	144	I>T		No	ClinGen Ensembl
rs1048417660 CA112835540	144	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	145	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1473332977 CA359035227	145	E>A		No	ClinGen TOPMed
CA359035230 rs1248170111	145	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	146	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3177289 rs139757569	148	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139757569 CA3177290	148	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359035199 rs1430685035	149	P>L		No	ClinGen gnomAD
CA3177287 rs750871816	151	I>V		No	ClinGen ExAC gnomAD
rs1478685789 CA359035169	154	V>G		No	ClinGen gnomAD
rs762232901 CA3177284	154	V>L		No	ClinGen ExAC gnomAD
rs1266187364 CA359035167	155	T>A		No	ClinGen gnomAD
CA3177283 rs142128231	155	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs142128231 CA359035164	155	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA359035150 rs1379712492	156	K>E		No	ClinGen TOPMed
rs1335924594 CA359035125	159	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1390144157 CA359035119	160	S>L		No	ClinGen gnomAD
rs904005324 CA112835084	161	P>R		No	ClinGen TOPMed
rs1303367135 CA359035107	163	V>M		No	ClinGen TOPMed
CA3177242 rs745541895	164	S>L		No	ClinGen ExAC TOPMed gnomAD
CA359035096 rs1385012886	165	R>G		No	ClinGen gnomAD
rs1186270876 CA359035094	165	R>K		No	ClinGen TOPMed gnomAD
rs757531846 CA3177240	167	T>M		No	ClinGen ExAC TOPMed gnomAD
CA359035057 rs1245575409	171	K>E		No	ClinGen TOPMed
rs1204626526 CA359035039	173	T>M		No	ClinGen gnomAD
CA359035032 rs1561079576	174	G>A		No	ClinGen Ensembl
CA359035017 rs1270167206	176	H>Q		No	ClinGen TOPMed
rs767604979 CA3177234	179	R>C		No	ClinGen ExAC TOPMed gnomAD
rs766686208 CA3177231	181	D>H		No	ClinGen ExAC TOPMed gnomAD
rs766686208 COSM1069541 CA3177232	181	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs534292159 CA112835026	182	P>L		No	ClinGen 1000Genomes
CA3177230 rs761496826	183	S>A		No	ClinGen ExAC gnomAD
rs768645745 CA3177228	185	K>N		No	ClinGen ExAC gnomAD
CA3177227 rs760728231	187	K>Q		No	ClinGen ExAC gnomAD
CA359034928 rs1364625285	189	K>Q		No	ClinGen gnomAD
CA112834987 rs919720194	192	R>C		No	ClinGen TOPMed
rs745415593 CA3177222	192	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770675558 CA3177220	193	V>M		No	ClinGen ExAC TOPMed gnomAD
rs138152607 CA3177218 CA359034829	197	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359034839 rs1490242326	197	D>H		No	ClinGen TOPMed gnomAD
CA359034841 rs1490242326	197	D>Y		No	ClinGen TOPMed gnomAD
CA3177216 rs748630491	198	E>K		No	ClinGen ExAC TOPMed gnomAD
rs781693901 CA3177215	199	S>L		No	ClinGen ExAC TOPMed gnomAD
rs751715567 CA3177213	200	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1187324219 CA359034806	200	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA359034773 rs1284619208	202	V>A		No	ClinGen gnomAD
rs758647631 CA3177211	203	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3177209 rs764006684	204	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1394784071 CA359034747	205	Y>H		No	ClinGen gnomAD
CA3177207 rs550883414	208	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1379933580 CA359034698	209	G>R		No	ClinGen gnomAD
rs1174331335 CA359034682	210	T>I		No	ClinGen gnomAD
CA3177205 rs758956291	212	D>N		No	ClinGen ExAC TOPMed gnomAD
rs773926512 CA3177204	213	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs773926512 CA112834935	213	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs770425518 CA3177203	213	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1248189898 CA359034631	214	K>N		No	ClinGen TOPMed gnomAD
CA359034624 rs1195057918	215	V>L		No	ClinGen TOPMed gnomAD
CA359034628 rs1195057918	215	V>M		No	ClinGen TOPMed gnomAD
CA359034599 rs1561079383	217	G>A		No	ClinGen Ensembl
rs1345590978 CA359034602	217	G>R		No	ClinGen gnomAD
CA359034591 rs1322228236	218	G>D		No	ClinGen gnomAD
rs1221140806 CA359034596	218	G>S		No	ClinGen TOPMed gnomAD

No associated diseases with O94811

No regional properties for O94811

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O94811

Functions

		Description
EC Number
Subcellular Localization	Golgi outpost Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton Nucleus Cytoplasm, cytoskeleton, spindle	Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity) Mainly localizes to the cytoskeleton (PubMed:18028908) Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908) Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies (PubMed:15590652, PubMed:17027006) During mitosis, colocalizes with LIMK2 at the mitotic spindle (PubMed:22328514)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
mitotic spindle	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
postsynaptic Golgi apparatus	The network of the Golgi apparatus structures located within the postsynapse.

5 GO annotations of molecular function

Name	Definition
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
magnesium ion binding	Binding to a magnesium (Mg) ion.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
tubulin binding	Binding to monomeric or multimeric forms of tubulin, including microtubules.

13 GO annotations of biological process

Name	Definition
astral microtubule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
microtubule bundle formation	A process that results in a parallel arrangement of microtubules.
microtubule nucleation by microtubule organizing center	The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.
microtubule polymerization	The addition of tubulin heterodimers to one or both ends of a microtubule.
myelin assembly	The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.
negative regulation of tubulin deacetylation	Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation.
oligodendrocyte development	The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
oligodendrocyte differentiation	The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
positive regulation of myelination	Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
positive regulation of protein polymerization	Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.
positive regulation of protein-containing complex assembly	Any process that activates or increases the frequency, rate or extent of protein complex assembly.
regulation of microtubule cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q27957	TPPP	Tubulin polymerization-promoting protein	Bos taurus (Bovine)	PR
Q7TQD2	Tppp	Tubulin polymerization-promoting protein	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MADKAKPAKA	ANRTPPKSPG	DPSKDRAAKR	LSLESEGAGE	GAAASPELSA	LEEAFRRFAV
70	80	90	100	110	120
HGDARATGRE	MHGKNWSKLC	KDCQVIDGRN	VTVTDVDIVF	SKIKGKSCRT	ITFEQFQEAL
130	140	150	160	170	180
EELAKKRFKD	KSSEEAVREV	HRLIEGKAPI	ISGVTKAISS	PTVSRLTDTT	KFTGSHKERF
190	200	210
DPSGKGKGKA	GRVDLVDESG	YVSGYKHAGT	YDQKVQGGK