AiPD: Autoinhibited Protein Database

Q712K3

Gene name	UBE2R2 (CDC34B, UBC3B)
Protein name	Ubiquitin-conjugating enzyme E2 R2
Names	E2 ubiquitin-conjugating enzyme R2, Ubiquitin carrier protein R2, Ubiquitin-conjugating enzyme E2-CDC34B, Ubiquitin-protein ligase R2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54926
EC number	2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-238 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

152-238 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q712K3

Entry ID	Method	Resolution	Chain	Position	Source
6NYO	X-ray	150 A	A	1-202	PDB
8PQL	EM	376 A	C	1-238	PDB
8Q7R	EM	371 A	C	1-238	PDB
8R5H	EM	344 A	C	1-192	PDB
AF-Q712K3-F1	Predicted				AlphaFoldDB

65 variants for Q712K3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	16	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	46	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767478191	60	A>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA373223566 rs1249869746	60	A>T		No	ClinGen gnomAD
rs926251179 COSM1231555 CA192534642	60	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs750352043 CA5029415	61	H>Q		No	ClinGen ExAC gnomAD
CA192534646 rs1056601087	61	H>Y		No	ClinGen Ensembl
rs952222575 CA373223635	63	K>I		No	ClinGen TOPMed gnomAD
CA192534647 rs952222575	63	K>T		No	ClinGen TOPMed gnomAD
CA5029417 rs766028687	66	I>T		No	ClinGen ExAC gnomAD
rs142075824 CA5029416	66	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA373223702 rs1482314218	67	D>E		No	ClinGen TOPMed
rs1207326879 CA373223819	75	F>L		No	ClinGen gnomAD
CA373223897 rs1564000408	80	K>R		No	ClinGen Ensembl
CA192534665 rs112637167	85	N>H		No	ClinGen Ensembl
CA192534669 rs113299589	85	N>T		No	ClinGen Ensembl
rs752304792 CA5029421	87	Y>C		No	ClinGen ExAC gnomAD
rs1247979664 CA373224032	87	Y>H		No	ClinGen gnomAD
CA192534675 rs113727596	88	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	91	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1363142234 CA373225415	98	H>R		No	ClinGen gnomAD
rs757997369 CA5029443	99	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5029445 rs750997097	121	R>K		No	ClinGen ExAC
CA373226882 rs1212018439	123	I>N		No	ClinGen TOPMed
TCGA novel	129	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA192552869 rs979918615	136	T>P		No	ClinGen Ensembl
rs1343682995 CA373226983	138	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA373226980 rs1587485400	138	S>P		No	ClinGen Ensembl
TCGA novel	139	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5029468 rs779184762	141	N>S		No	ClinGen ExAC gnomAD
rs1468024826 CA373227030	146	V>I		No	ClinGen gnomAD
rs1392032219 CA373227040	147	M>T		No	ClinGen gnomAD
CA373227046 COSM1462095 rs1447755159	148	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs200839853 CA192552899	153	D>V		No	ClinGen 1000Genomes
rs776445334 CA5029474	154	S>N		No	ClinGen ExAC gnomAD
CA5029475 rs745750000	157	K>R		No	ClinGen ExAC gnomAD
rs769740820 CA5029476	158	D>E		No	ClinGen ExAC
TCGA novel	163	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA192557178 rs944112225	170	S>L		No	ClinGen TOPMed
rs1315118319 CA373227587	170	S>P		No	ClinGen gnomAD
CA5029499 rs749159569	172	T>S		No	ClinGen ExAC gnomAD
rs773893146 CA5029501	175	E>K		No	ClinGen ExAC gnomAD
rs771516938 CA5029503	177	E>D		No	ClinGen ExAC gnomAD
rs772731336 CA5029504	180	G>V		No	ClinGen ExAC gnomAD
TCGA novel	183	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5029505 rs760157116	185	T>K		No	ClinGen ExAC gnomAD
CA373227703 rs1181178013	188	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	191	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1202336903 CA373227751	195	K>E		No	ClinGen TOPMed
rs763320246 CA5029508	199	N>S		No	ClinGen ExAC gnomAD
COSM455857 CA192557252 rs372565481	201	N>K	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
TCGA novel	202	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145589627 CA5029511	204	D>N		No	ClinGen ESP ExAC
CA373227839 rs1320272305 COSM291309	208	D>N	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA373227860 rs1200306189	210	L>F		No	ClinGen Ensembl
CA5029517 rs143620598	214	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA373227914 rs1564008880	217	D>E		No	ClinGen Ensembl
rs778731566 CA5029520	219	D>E		No	ClinGen ExAC TOPMed
rs1026908813 CA192557356	225	A>V		No	ClinGen TOPMed
CA5029522 rs771807900	226	D>N		No	ClinGen ExAC TOPMed gnomAD
CA373227993 rs1564008900	228	Y>H		No	ClinGen Ensembl
rs867080039 CA192557398	234	G>E		No	ClinGen Ensembl
rs1455175817 CA373228039	234	G>R		No	ClinGen gnomAD
TCGA novel	236	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA192557402 rs960341662	238	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD

No associated diseases with Q712K3

2 regional properties for Q712K3

Type	Name	Position	InterPro Accession
domain	Ubiquitin-conjugating enzyme E2	8 - 174	IPR000608
active_site	Ubiquitin-conjugating enzyme, active site	82 - 97	IPR023313

Functions

		Description
EC Number	2.3.2.23	Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity	Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

4 GO annotations of biological process

Name	Definition
protein K48-linked ubiquitination	A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
protein monoubiquitination	Addition of a single ubiquitin group to a protein.
protein polyubiquitination	Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P49427	CDC34	Ubiquitin-conjugating enzyme E2 R1	Homo sapiens (Human)	PR
Q8CFI2	Cdc34	Ubiquitin-conjugating enzyme E2 R1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAQQQMTSSQ	KALMLELKSL	QEEPVEGFRI	TLVDESDLYN	WEVAIFGPPN	TLYEGGYFKA
70	80	90	100	110	120
HIKFPIDYPY	SPPTFRFLTK	MWHPNIYENG	DVCISILHPP	VDDPQSGELP	SERWNPTQNV
130	140	150	160	170	180
RTILLSVISL	LNEPNTFSPA	NVDASVMFRK	WRDSKGKDKE	YAEIIRKQVS	ATKAEAEKDG
190	200	210	220	230
VKVPTTLAEY	CIKTKVPSND	NSSDLLYDDL	YDDDIDDEDE	EEEDADCYDD	DDSGNEES