AiPD: Autoinhibited Protein Database

Gene name	Marchf6 (Kiaa0597, March6)
Protein name	E3 ubiquitin-protein ligase MARCHF6
Names	Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, RING-type E3 ubiquitin transferase MARCHF6
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:223455
EC number	2.3.2.27: Aminoacyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

158-280 (Predicted disordered autoinhibitory region) PR

158-280 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6ZQ89-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389357171	79	F>Y	No	EVA
rs3389346647	88	T>N	No	EVA
rs3389352504	89	A>T	No	EVA
rs3404451367	176	L>V	No	EVA
rs3389318359	206	D>Y	No	EVA
rs3389346580	227	G>D	No	EVA
rs3389353799	235	D>N	No	EVA
rs3389353728	236	N>K	No	EVA
rs3389318292	249	D>G	No	EVA
rs3389346663	289	H>Y	No	EVA
rs3389355435	405	T>I	No	EVA
rs3389359964	425	W>C	No	EVA
rs3405666740	491	V>A	No	EVA
rs3389352532	536	L>S	No	EVA
rs3389327929	545	T>M	No	EVA
rs3389327883	605	A>V	No	EVA
rs218931727	822	V>I	No	EVA
rs229784733	830	A>V	No	EVA
rs3389346618	835	G>A	No	EVA
rs3389350838	845	H>Y	No	EVA
rs3389327905	847	R>E	No	EVA
rs3389357103	848	I>F	No	EVA
rs3389366958	857	V>A	No	EVA
rs3389276014	875	H>Y	No	EVA
rs3389370882	877	K>*	No	EVA
rs3389370893	884	G>E	No	EVA

Type	Name	Position	InterPro Accession
domain	MAGE homology domain	85 - 285	IPR002190

		Description
EC Number	2.3.2.27	Aminoacyltransferases
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
ubiquitin conjugating enzyme binding	Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
ubiquitin-specific protease binding	Binding to a ubiquitin-specific protease.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
proteasomal protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein K48-linked ubiquitination	A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O60337	MARCHF6	E3 ubiquitin-protein ligase MARCHF6	Homo sapiens (Human)	PR
Q6NZQ8	Marchf1	E3 ubiquitin-protein ligase MARCHF1	Mus musculus (Mouse)	PR
Q28IK8	marchf8	E3 ubiquitin-protein ligase MARCHF8	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR