Q28IK8

PR
Gene name
marchf8 (march8, TNeu072c23.1)
Protein name
E3 ubiquitin-protein ligase MARCHF8
Names
Membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MARCH-VIII, RING-type E3 ubiquitin transferase MARCHF8
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448095
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28IK8

Entry ID Method Resolution Chain Position Source
AF-Q28IK8-F1 Predicted AlphaFoldDB

No variants for Q28IK8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28IK8

No associated diseases with Q28IK8

2 regional properties for Q28IK8

Type Name Position InterPro Accession
domain Zinc finger, RING-type 53 - 100 IPR001841
domain Zinc finger, RING-CH-type 45 - 106 IPR011016

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Cytoplasmic vesicle membrane ; Multi-pass membrane protein
  • Lysosome membrane ; Multi-pass membrane protein
  • Early endosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome membrane The lipid bilayer surrounding an early endosome.
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

4 GO annotations of molecular function

Name Definition
MHC protein binding Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
antigen processing and presentation of peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60337 MARCHF6 E3 ubiquitin-protein ligase MARCHF6 Homo sapiens (Human) PR
Q6NZQ8 Marchf1 E3 ubiquitin-protein ligase MARCHF1 Mus musculus (Mouse) PR
Q6ZQ89 Marchf6 E3 ubiquitin-protein ligase MARCHF6 Mus musculus (Mouse) PR
10 20 30 40 50 60
MHSCWKMKLQ NEKTLGHSVS RSSNISKAGS PTSVSAPSSF PRTSVTPSSQ DICRICHCEG
70 80 90 100 110 120
DDESPLITPC HCTGSLHFVH QACLQQWIKS SDTRCCELCK FEFIMETKLK PLRKWEKLQM
130 140 150 160 170 180
TASERRKIMC SVTFHVIAIT CVVWSLYVLI DRTAEEIKMG QNNGILEWPF WTKLVVVAIG
190 200 210 220 230 240
FTGGLLFMYV QCKVYVQLWK RLKAYNRVIY VQNCPETCKK KIFEKSVIIE PNLESKEALG
250 260
IHHSDTNSSY YTEPEDCGAA ILQV