AiPD: Autoinhibited Protein Database

Gene name	Drc7 (Ccdc135, Gm770, Srgl)
Protein name	Dynein regulatory complex subunit 7
Names	Coiled-coil domain-containing protein 135, Coiled-coil domain-containing protein lobo homolog, Spermatogenesis-related gene in late stages of spermatogenesis cells protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:330830
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-70 (Predicted disordered autoinhibitory region) PR

1-70 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6V3W6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389004040	26	T>I	No	EVA
rs3388983221	45	L>V	No	EVA
rs3388971791	54	E>G	No	EVA
rs245193873	65	Q>P	No	EVA
rs3389000955	144	L>P	No	EVA
rs3388999759	153	F>I	No	EVA
rs3388983261	201	S>F	No	EVA
rs3389003982	209	N>Y	No	EVA
rs3388952656	210	G>V	No	EVA
rs3388999761	234	E>G	No	EVA
rs3388995819	269	Q>*	No	EVA
rs252176710	334	E>D	No	EVA
rs3388999770	401	V>M	No	EVA
rs3389006835	433	R>H	No	EVA
rs3388989627	441	I>M	No	EVA
rs222220229	441	I>V	No	EVA
rs3388952701	452	S>P	No	EVA
rs3388977876	456	N>Y	No	EVA
rs3388989653	463	R>G	No	EVA
rs3388999723	518	Y>F	No	EVA
rs3389002610	556	G>W	No	EVA
rs3388999685	560	F>Y	No	EVA
rs3388977899	569	G>E	No	EVA
rs252613031	595	S>Y	No	EVA
rs235299796	610	L>V	No	EVA
rs3388977865	611	F>L	No	EVA
rs3413061518	658	S>G	No	EVA
rs3388983237	830	C>Y	No	EVA
rs3389007402	849	E>D	No	EVA
rs3388989620	861	K>R	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q6V3W6

		Description
EC Number
Subcellular Localization	Cell projection, cilium, flagellum Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, flagellum axoneme	Associated with the outer doublet microtubules (OD)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
motile cilium	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

Name	Definition
No GO annotations for molecular function

Name	Definition
cell motility	Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
flagellated sperm motility	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
sperm axoneme assembly	The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9M4	DRC7	Dynein regulatory complex subunit 7	Bos taurus (Bovine)	PR
G2HE57	DRC7	Dynein regulatory complex subunit 7	Pan troglodytes (Chimpanzee)	PR
Q8IY82	DRC7	Dynein regulatory complex subunit 7	Homo sapiens (Human)	PR