Q2T9M4
PR
Gene name |
DRC7 (CCDC135) |
Protein name |
Dynein regulatory complex subunit 7 |
Names |
Coiled-coil domain-containing protein 135, Coiled-coil domain-containing protein lobo homolog |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:504736 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2T9M4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2T9M4-F1 | Predicted | AlphaFoldDB |
221 variants for Q2T9M4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs797631240 | 18 | E>A | No | EVA | |
| rs436356472 | 32 | P>R | No | EVA | |
| rs454863598 | 34 | E>D | No | EVA | |
| rs467016742 | 35 | V>G | No | EVA | |
| rs434249936 | 59 | V>G | No | EVA | |
| rs452867736 | 64 | K>N | No | EVA | |
| rs436763327 | 68 | F>L | No | EVA | |
| rs469940471 | 68 | F>Y | No | EVA | |
| rs455352518 | 70 | K>N | No | EVA | |
| rs471543986 | 74 | D>A | No | EVA | |
| rs453233974 | 74 | D>N | No | EVA | |
| rs471543986 | 74 | D>V | No | EVA | |
| rs438662751 | 75 | T>A | No | EVA | |
| rs438662751 | 75 | T>P | No | EVA | |
| rs451696575 | 76 | S>P | No | EVA | |
| rs443719592 | 80 | L>F | No | EVA | |
| rs443719592 | 80 | L>V | No | EVA | |
| rs462123562 | 81 | S>A | No | EVA | |
| rs462123562 | 81 | S>P | No | EVA | |
| rs459923096 | 82 | Y>* | No | EVA | |
| rs480685488 | 82 | Y>H | No | EVA | |
| rs480685488 | 82 | Y>N | No | EVA | |
| rs441421319 | 82 | Y>S | No | EVA | |
| rs478202138 | 83 | Q>K | No | EVA | |
| rs469843610 | 84 | S>N | No | EVA | |
| rs481939870 | 84 | S>R | No | EVA | |
| rs445437119 | 84 | S>R | No | EVA | |
| rs469843610 | 84 | S>T | No | EVA | |
| rs448898462 | 85 | N>T | No | EVA | |
| rs467348292 | 86 | T>A | No | EVA | |
| rs460203095 | 86 | T>M | No | EVA | |
| rs467348292 | 86 | T>P | No | EVA | |
| rs465301820 | 87 | L>H | No | EVA | |
| rs465301820 | 87 | L>P | No | EVA | |
| rs465301820 | 87 | L>R | No | EVA | |
| rs457099945 | 88 | K>R | No | EVA | |
| rs475626421 | 89 | E>A | No | EVA | |
| rs475626421 | 89 | E>G | No | EVA | |
| rs475626421 | 89 | E>V | No | EVA | |
| rs455760514 | 90 | E>A | No | EVA | |
| rs474002071 | 90 | E>D | No | EVA | |
| rs455760514 | 90 | E>G | No | EVA | |
| rs437250419 | 90 | E>K | No | EVA | |
| rs437250419 | 90 | E>Q | No | EVA | |
| rs441209137 | 91 | H>L | No | EVA | |
| rs441209137 | 91 | H>P | No | EVA | |
| rs441209137 | 91 | H>R | No | EVA | |
| rs471933518 | 92 | L>P | No | EVA | |
| rs471933518 | 92 | L>R | No | EVA | |
| rs459861740 | 92 | L>V | No | EVA | |
| rs482488711 | 93 | L>P | No | EVA | |
| rs482488711 | 93 | L>Q | No | EVA | |
| rs482488711 | 93 | L>R | No | EVA | |
| rs463929784 | 93 | L>V | No | EVA | |
| rs448918460 | 94 | Q>E | No | EVA | |
| rs448918460 | 94 | Q>K | No | EVA | |
| rs461049102 | 94 | Q>P | No | EVA | |
| rs461049102 | 94 | Q>R | No | EVA | |
| rs479395399 | 95 | V>A | No | EVA | |
| rs479395399 | 95 | V>G | No | EVA | |
| rs446490125 | 96 | A>G | No | EVA | |
| rs450710049 | 97 | D>A | No | EVA | |
| rs469159581 | 97 | D>E | No | EVA | |
| rs432215050 | 97 | D>H | No | EVA | |
| rs432215050 | 97 | D>N | No | EVA | |
| rs432215050 | 97 | D>Y | No | EVA | |
| rs436233640 | 98 | N>H | No | EVA | |
| rs455810393 | 98 | N>I | No | EVA | |
| rs474140971 | 98 | N>K | No | EVA | |
| rs455810393 | 98 | N>T | No | EVA | |
| rs434725406 | 99 | F>L | No | EVA | |
| rs453159162 | 99 | F>S | No | EVA | |
| rs471624098 | 100 | S>A | No | EVA | |
| rs471624098 | 100 | S>P | No | EVA | |
| rs439045514 | 100 | S>Y | No | EVA | |
| rs464025025 | 101 | R>L | No | EVA | |
| rs464025025 | 101 | R>P | No | EVA | |
| rs476045787 | 103 | Y>H | No | EVA | |
| rs443034814 | 106 | L>M | No | EVA | |
| rs461025984 | 107 | C>G | No | EVA | |
| rs479532400 | 110 | R>C | No | EVA | |
| rs446576805 | 111 | V>M | No | EVA | |
| rs477003990 | 112 | P>T | No | EVA | |
| rs450766404 | 113 | L>R | No | EVA | |
| rs469295780 | 114 | F>V | No | EVA | |
| rs448214308 | 116 | H>R | No | EVA | |
| rs466627557 | 119 | N>S | No | EVA | |
| rs466627557 | 119 | N>T | No | EVA | |
| rs434815212 | 120 | E>A | No | EVA | |
| rs453294020 | 121 | C>S | No | EVA | |
| rs465150116 | 123 | V>G | No | EVA | |
| rs432420001 | 124 | P>A | No | EVA | |
| rs458092926 | 128 | S>R | No | EVA | |
| rs476401681 | 130 | T>S | No | EVA | |
| rs443450625 | 139 | P>T | No | EVA | |
| rs462991172 | 146 | T>S | No | EVA | |
| rs481487902 | 159 | P>H | No | EVA | |
| rs442159424 | 160 | L>F | No | EVA | |
| rs441484706 | 167 | P>R | No | EVA | |
| rs459740894 | 174 | T>A | No | EVA | |
| rs478452359 | 177 | L>V | No | EVA | |
| rs444927164 | 178 | K>* | No | EVA | |
| rs462424373 | 186 | D>N | No | EVA | |
| rs481852311 | 187 | F>V | No | EVA | |
| rs448930042 | 196 | I>T | No | EVA | |
| rs434630218 | 199 | G>D | No | EVA | |
| rs432217612 | 200 | Y>F | No | EVA | |
| rs465120177 | 200 | Y>H | No | EVA | |
| rs437282757 | 210 | S>P | No | EVA | |
| rs455542946 | 219 | T>S | No | EVA | |
| rs447035929 | 220 | R>W | No | EVA | |
| rs441420982 | 222 | V>G | No | EVA | |
| rs474014129 | 222 | V>L | No | EVA | |
| rs453588451 | 226 | T>P | No | EVA | |
| rs472014277 | 227 | M>L | No | EVA | |
| rs439017633 | 230 | K>Q | No | EVA | |
| rs477428725 | 248 | P>H | No | EVA | |
| rs450945320 | 250 | R>S | No | EVA | |
| rs469391718 | 256 | F>V | No | EVA | |
| rs448805661 | 260 | Q>K | No | EVA | |
| rs467167165 | 261 | E>* | No | EVA | |
| rs434213951 | 265 | Q>K | No | EVA | |
| rs452096449 | 271 | E>A | No | EVA | |
| rs464292377 | 273 | E>K | No | EVA | |
| rs472118163 | 277 | K>N | No | EVA | |
| rs515955967 | 285 | E>K | No | EVA | |
| rs437615283 | 287 | E>G | No | EVA | |
| rs435193422 | 288 | N>T | No | EVA | |
| rs468003065 | 288 | N>Y | No | EVA | |
| rs453863222 | 289 | A>P | No | EVA | |
| rs439508479 | 290 | K>M | No | EVA | |
| rs451443985 | 290 | K>N | No | EVA | |
| rs476418979 | 291 | T>S | No | EVA | |
| rs378366887 | 353 | W>L | No | EVA | |
| rs454184340 | 365 | D>G | No | EVA | |
| rs443564103 | 409 | F>I | No | EVA | |
| rs439736889 | 422 | S>Y | No | EVA | |
| rs436016107 | 426 | F>S | No | EVA | |
| rs473069261 | 435 | K>N | No | EVA | |
| rs433855496 | 436 | V>G | No | EVA | |
| rs452187226 | 437 | I>T | No | EVA | |
| rs470813183 | 442 | A>V | No | EVA | |
| rs463843473 | 458 | C>S | No | EVA | |
| rs442809296 | 467 | E>G | No | EVA | |
| rs475970253 | 467 | E>K | No | EVA | |
| rs442950665 | 474 | M>I | No | EVA | |
| rs454923533 | 476 | E>G | No | EVA | |
| rs473436305 | 477 | W>G | No | EVA | |
| rs721271403 | 478 | Y>F | No | EVA | |
| rs459209594 | 503 | P>R | No | EVA | |
| rs440728655 | 503 | P>S | No | EVA | |
| rs477762449 | 508 | A>S | No | EVA | |
| rs1117909858 | 510 | R>H | No | EVA | |
| rs449945403 | 511 | V>G | No | EVA | |
| rs454312833 | 517 | M>V | No | EVA | |
| rs466306557 | 527 | F>V | No | EVA | |
| rs433343700 | 530 | T>K | No | EVA | |
| rs451825471 | 533 | V>G | No | EVA | |
| rs476307988 | 540 | E>G | No | EVA | |
| rs443349235 | 543 | P>T | No | EVA | |
| rs455325477 | 544 | K>Q | No | EVA | |
| rs441119907 | 545 | T>M | No | EVA | |
| rs446437561 | 548 | E>D | No | EVA | |
| rs459610881 | 553 | R>W | No | EVA | |
| rs438541195 | 555 | D>A | No | EVA | |
| rs463520397 | 556 | F>L | No | EVA | |
| rs483160216 | 558 | S>F | No | EVA | |
| rs468393862 | 571 | L>V | No | EVA | |
| rs384810635 | 572 | A>P | No | EVA | |
| rs482509581 | 590 | F>V | No | EVA | |
| rs443181583 | 593 | N>S | No | EVA | |
| rs455630110 | 599 | D>E | No | EVA | |
| rs480035976 | 599 | D>G | No | EVA | |
| rs719684925 | 604 | E>K | No | EVA | |
| rs464992148 | 606 | V>G | No | EVA | |
| rs477150471 | 614 | I>S | No | EVA | |
| rs136356366 | 619 | H>P | No | EVA | |
| rs450356354 | 622 | S>P | No | EVA | |
| rs468853537 | 624 | H>P | No | EVA | |
| rs454713247 | 632 | F>L | No | EVA | |
| rs466584544 | 634 | R>G | No | EVA | |
| rs433736084 | 634 | R>L | No | EVA | |
| rs471830293 | 636 | T>P | No | EVA | |
| rs457315368 | 638 | V>G | No | EVA | |
| rs475830918 | 640 | S>R | No | EVA | |
| rs443120118 | 642 | G>V | No | EVA | |
| rs480165772 | 648 | T>A | No | EVA | |
| rs440554572 | 648 | T>N | No | EVA | |
| rs480165772 | 648 | T>P | No | EVA | |
| rs459151698 | 650 | D>H | No | EVA | |
| rs477140709 | 653 | I>T | No | EVA | |
| rs450540020 | 655 | F>C | No | EVA | |
| rs468792136 | 656 | E>D | No | EVA | |
| rs449859274 | 657 | V>G | No | EVA | |
| rs436473561 | 695 | L>R | No | EVA | |
| rs433943591 | 715 | Y>S | No | EVA | |
| rs109899111 | 723 | C>S | No | EVA | |
| rs464817680 | 725 | E>D | No | EVA | |
| rs479145152 | 732 | R>C | No | EVA | |
| rs446132828 | 735 | H>R | No | EVA | |
| rs464367250 | 737 | E>G | No | EVA | |
| rs482797628 | 739 | L>R | No | EVA | |
| rs450008976 | 742 | V>E | No | EVA | |
| rs468663583 | 745 | Q>L | No | EVA | |
| rs447855139 | 746 | L>R | No | EVA | |
| rs435889680 | 746 | L>V | No | EVA | |
| rs466366047 | 751 | P>Q | No | EVA | |
| rs451451753 | 755 | Q>H | No | EVA | |
| rs432853723 | 755 | Q>P | No | EVA | |
| rs476329405 | 756 | L>P | No | EVA | |
| rs474121956 | 763 | T>K | No | EVA | |
| rs459531748 | 774 | C>G | No | EVA | |
| rs471598836 | 778 | F>I | No | EVA | |
| rs458044232 | 784 | D>A | No | EVA | |
| rs482934768 | 786 | A>P | No | EVA | |
| rs449945467 | 787 | N>S | No | EVA | |
| rs462027386 | 790 | Q>K | No | EVA | |
| rs480943941 | 791 | A>P | No | EVA | |
| rs876296151 | 807 | Y>D | No | EVA | |
| rs479562074 | 812 | V>G | No | EVA | |
| rs441350907 | 862 | P>A | No | EVA |
No associated diseases with Q2T9M4
No regional properties for Q2T9M4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q2T9M4 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell motility | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. |
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| sperm axoneme assembly | The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVLKEKVEE | EEAAEREEAA | ERAERGEKTK | RPMEVRREET | TMTQEMLRDL | ERKLSEIEVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPEKLLAFTK | DTIDTSKLPL | SYQSNTLKEE | HLLQVADNFS | RQYSHLCPDR | VPLFLHPLNE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CEVPKFVSTT | IRPTLMPYPE | LYNWDTCAQF | ISDFLSMVPL | PDPLKPPLYL | YSSTTVLKYQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KGNCFDFSTL | LCSMLIGAGY | DAYCVNGYGS | QDLCHMDLTR | EVCPLTMKPK | ESVKEEEKAP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKKYAIKPPR | DLTSRFEQEQ | EMKRQEAIKA | EEENRRKQEE | ARLLEQENAK | TDPLHGLRVH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SWVLVLSGKR | EVPESFFIDP | FTARSYSTQD | DHFLGIESLW | NHKNYWVNMQ | DCWNCCKDLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDLGDPVRWE | YLLLGTDKPF | LSLTEEEDEG | MNDDDDVENL | GKEDEDKSFD | MPPSWVEQIE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ISPEAFETRC | PNGKKVIQYK | RAKLEKWAPY | LNNNGLVCRL | TTYEDLECTK | TLEMKEWYQN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| REDMLELKHI | NKITGLNVDY | FKPGHPQALR | VHSYKSMQPE | MDRVMEFYET | ARVDGLIKRE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ETPKTMTEHY | QGRPDFLSYR | HVNFGPRMKK | LALNSAESNP | RPMVKITERF | FRNPAKPADE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DVAERVFLIA | EERIQLRYHC | RSDHITANKR | EFLRRTEVDS | KGNKIIMTPD | MCISFEVEPM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EHTKKLLYQY | EAMMKLKNEE | KLSRHQAWES | ELEVLEILKL | REEEEEAHTL | TISIYDTKRN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EKCKEYREAM | ERVLHEEHLR | QVEAQLDYLA | PFLAQLPPGE | KLTRWQAVRL | KDECLNDFKQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RLIDKANLIQ | ARFEKETQEL | QKKQQWYQEN | QVTLTPEDED | LYLSYCSQAM | FRIRILEQRL |
| 850 | 860 | 870 | |||
| SRHKELAPLK | YLALEEKLYK | DPRLVELLKV | FV |