G2HE57

PR
Gene name
DRC7 (CCDC135)
Protein name
Dynein regulatory complex subunit 7
Names
Coiled-coil domain-containing protein 135, Coiled-coil domain-containing protein lobo homolog
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
ptr:454123
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for G2HE57

Entry ID Method Resolution Chain Position Source
AF-G2HE57-F1 Predicted AlphaFoldDB

No variants for G2HE57

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G2HE57

No associated diseases with G2HE57

No regional properties for G2HE57

Type Name Position InterPro Accession
No domain, repeats, and functional sites for G2HE57

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium, flagellum
  • Cytoplasm, cytoskeleton, cilium axoneme
  • Cytoplasm, cytoskeleton, flagellum axoneme
  • Associated with the outer doublet microtubules (OD)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
sperm axoneme assembly The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2T9M4 DRC7 Dynein regulatory complex subunit 7 Bos taurus (Bovine) PR
Q8IY82 DRC7 Dynein regulatory complex subunit 7 Homo sapiens (Human) PR
Q6V3W6 Drc7 Dynein regulatory complex subunit 7 Mus musculus (Mouse) PR
10 20 30 40 50 60
MEVLREKVEE EEEAEREEAA ERAEWARMEK MMRPVEVRKE ENTLKQETLR DLEKKLSEIQ
70 80 90 100 110 120
ITVSAELPAF TKDTIDISKL PVSYKTNTPK EEHLLQVADN FSCQYSHLCP DRVPLFLHPL
130 140 150 160 170 180
NECEVPKFVS TTLRPTLMPY PELYNWDSCA QFVSDFLTMV PLPDPLKPPS HLYSSTTVLK
190 200 210 220 230 240
YQKGNCFDFS TLLCSMLIGS GYDAYCVNGY GSLDLCHMDL TREVCPLTVK PKETIKKEEK
250 260 270 280 290 300
VLPKKYTIKP PRDLCSRFEQ EQEVKKQQEI RAQEKKRLRE EEERLMEAEK AKPDALHGLR
310 320 330 340 350 360
VHSWVLVLSG KREVPENFFI DPFTGHSYST QDEHFLGIES LWNHKNYWIN MQDCWNCCKD
370 380 390 400 410 420
LIFDLGDPVR WEYMLLGTDK SQLSLTEEDD SGINDEDDVE NLGKEDEDKS FDMPHSWVEQ
430 440 450 460 470 480
IEISPEAFET RCPNGKKVIQ YKRAKLEKWA PYLNSNGLVS RLTTYEDLQC TNILEIKEWY
490 500 510 520 530 540
QNREDMLELK HINKTTDLKT DYFKPGHPQA LRVHSYKSMQ PEMDRVIEFY ETARVDGLMK
550 560 570 580 590 600
REETPRTMTE YYQGRPDFLS YRHASFGPRV KKLTLSSAES NPRPIVKITE RFFRNPAKPA
610 620 630 640 650 660
EEDVAERVFL VAEERIQLRY HCREDHITAS KREFLRRTEV DSKGNKIIMT PDMCISFEVE
670 680 690 700 710 720
PMEHTKKLLY QYEAMMHLKR EEKLSRHQVW ESELEVLEIL KLREEEEAAH TLTISIYDTK
730 740 750 760 770 780
RNEKSKEYRE AMERMMHEEH LRQVETQLDY LAPFLAQLPP GEKLTRWQAV RLKDECLSDF
790 800 810 820 830 840
KQRLINKANL IQARFEKETQ ELQKKQQWYQ ENQVTLTPED EDLYLSYCSQ AMFRIRILEQ
850 860 870
RLNRHKELAP LKYLALEEKL YKDPRLGELQ KIFA