Q6S7B0
Gene name |
TAF5 (At5g25150, F21J6) |
Protein name |
Transcription initiation factor TFIID subunit 5 |
Names |
TBP-associated factor 5, AtTAF5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G25150 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6S7B0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6S7B0-F1 | Predicted | AlphaFoldDB |
34 variants for Q6S7B0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07038147 | 21 | S>T | No | 1000Genomes | |
| ENSVATH03118447 | 30 | H>N | No | 1000Genomes | |
| ENSVATH00646543 | 35 | N>S | No | 1000Genomes | |
| tmp_5_8677228_T_G | 38 | S>A | No | 1000Genomes | |
| ENSVATH03118449 | 42 | V>I | No | 1000Genomes | |
| ENSVATH07038171 | 96 | V>A | No | 1000Genomes | |
| ENSVATH00646546 | 115 | A>T | No | 1000Genomes | |
| ENSVATH00646547 | 132 | L>I | No | 1000Genomes | |
| tmp_5_8678033_C_G | 135 | L>V | No | 1000Genomes | |
| ENSVATH14183318 | 141 | P>L | No | 1000Genomes | |
| ENSVATH03118505 | 196 | S>L | No | 1000Genomes | |
| ENSVATH07038192 | 253 | G>E | No | 1000Genomes | |
| tmp_5_8678825_A_C | 254 | Q>P | No | 1000Genomes | |
| ENSVATH07038193 | 257 | S>G | No | 1000Genomes | |
| tmp_5_8678858_G_A | 265 | S>N | No | 1000Genomes | |
| ENSVATH11025033 | 272 | I>V | No | 1000Genomes | |
| ENSVATH11025034 | 287 | A>G | No | 1000Genomes | |
| tmp_5_8679016_G_A | 292 | A>T | No | 1000Genomes | |
| tmp_5_8679026_C_T | 295 | A>V | No | 1000Genomes | |
| ENSVATH03118521 | 300 | I>V | No | 1000Genomes | |
| ENSVATH03118522 | 304 | P>S | No | 1000Genomes | |
| ENSVATH07038203 | 362 | H>L | No | 1000Genomes | |
| ENSVATH11025078 | 376 | I>V | No | 1000Genomes | |
| tmp_5_8679619_G_A | 378 | V>I | No | 1000Genomes | |
| ENSVATH00646550 | 393 | Q>P | No | 1000Genomes | |
| ENSVATH03118548 | 394 | A>G | No | 1000Genomes | |
| ENSVATH00646551 | 404 | G>R | No | 1000Genomes | |
| ENSVATH07038213 | 450 | N>I | No | 1000Genomes | |
| tmp_5_8680228_C_A | 470 | P>T | No | 1000Genomes | |
| ENSVATH11025142 | 567 | T>N | No | 1000Genomes | |
| tmp_5_8680963_G_A | 576 | A>T | No | 1000Genomes | |
| tmp_5_8681493_G_A | 598 | G>S | No | 1000Genomes | |
| ENSVATH11025200 | 639 | T>I | No | 1000Genomes | |
| tmp_5_8682051_C_T | 668 | A>V | No | 1000Genomes |
No associated diseases with Q6S7B0
11 regional properties for Q6S7B0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 341 - 381 | IPR001680-1 |
| repeat | WD40 repeat | 406 - 446 | IPR001680-2 |
| repeat | WD40 repeat | 449 - 623 | IPR001680-3 |
| domain | TFIID subunit TAF5, NTD2 domain | 61 - 195 | IPR007582 |
| conserved_site | WD40 repeat, conserved site | 367 - 381 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 517 - 531 | IPR019775-2 |
| conserved_site | WD40 repeat, conserved site | 559 - 573 | IPR019775-3 |
| conserved_site | WD40 repeat, conserved site | 601 - 615 | IPR019775-4 |
| repeat | G-protein beta WD-40 repeat | 433 - 447 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 517 - 531 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 601 - 615 | IPR020472-3 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transcription initiation at RNA polymerase II promoter | A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPEQINEFV | VGYLKKKGFS | SAAKDLESYH | HQNNNGSSFT | SVDYHNDPEL | TKLIRSFSQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDDPTRYREG | YSKLRSWAYN | SLDLYKHELL | RVMYPVFIHC | YMDLVGKGHT | QEARAFFNSF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKDHEMVHLR | DLQKLEGVLS | PSHLEEMEFA | RSLRKSKVNI | KFCQYSYELL | LQYLHSTVST |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LMLGIINEHI | NFQVYSGQPT | SSSDDIEAVT | IVGSFQDTAN | HINQKEIQWG | LLEDSLEDRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EKTGGLLSDS | EKGQGESKDG | DADDSKKRST | EIGKQGSSLK | KLKKDKAGNA | TAKVARLETI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TVSPAPRVKP | ELALPVMSTD | VEQSILEDLR | NRVQLSSVAM | PSVSFYTFVN | THNGLNCSSI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SHDGSLVAGG | FSDSSIKVWD | MAKIGQAGSG | ALQAENDSSD | QSIGPNGRRS | YTLLLGHSGP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VYSATFSPPG | DFVLSSSADT | TIRLWSTKLN | ANLVCYKGHN | YPVWDAQFSP | FGHYFASCSH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DRTARIWSMD | RIQPLRIMAG | HLSDVDCVQW | HPNCNYIATG | SSDKTVRLWD | VQTGECVRIF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IGHRSMVLSL | AMSPDGRYMA | SGDEDGTIMM | WDLSTARCIT | PLMGHNSCVW | SLSYSGEGSL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LASGSADCTV | KLWDVTSSTK | LTKAEEKNGN | SNRLRSLRTF | PTKSTPVHAL | RFSRRNLLFA |
| AGAISKPAN |