P49846
Gene name |
Taf5 (TAF80, CG7704) |
Protein name |
Transcription initiation factor TFIID subunit 5 |
Names |
TAFII-80, Transcription initiation factor TFIID 85 kDa subunit, p85 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG7704 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P49846
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P49846-F1 | Predicted | AlphaFoldDB |
No variants for P49846
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P49846 | |||||
No associated diseases with P49846
7 regional properties for P49846
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 367 - 414 | IPR001680-1 |
| repeat | WD40 repeat | 439 - 646 | IPR001680-2 |
| domain | TFIID subunit TAF5, NTD2 domain | 112 - 245 | IPR007582 |
| conserved_site | WD40 repeat, conserved site | 591 - 605 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 465 - 479 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 549 - 563 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 591 - 605 | IPR020472-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transcription initiation at RNA polymerase II promoter | A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLEVSNING | GNGTQLSHDK | RELLCLLKLI | KKYQLKSTEE | LLCQEANVSS | VELSEISESD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VQQVLGAVLG | AGDANRERKH | VQSPAQGHKQ | SAVTEANAAE | ELAKFIDDDS | FDAQHYEQAY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KELRTFVEDS | LDIYKHELSM | VLYPILVQIY | FKILASGLRE | KAKEFIEKYK | CDLDGYYIEG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFNLLLLSKP | EELLENDLVV | AMEQDKFVIR | MSRDSHSLFK | RHIQDRRQEV | VADIVSKYLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FDTYEGMARN | KLQCVATAGS | HLGEAKRQDN | KMRVYYGLLK | EVDFQTLTTP | APAPEEEDDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDAPDRPKKK | KPKKDPLLSK | KSKSDPNAPS | IDRIPLPELK | DSDKLLKLKA | LREASKRLAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SKDQLPSAVF | YTVLNSHQGV | TCAEISDDST | MLACGFGDSS | VRIWSLTPAK | LRTLKDADSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RELDKESADI | NVRMLDDRSG | EVTRSLMGHT | GPVYRCAFAP | EMNLLLSCSE | DSTIRLWSLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TWSCVVTYRG | HVYPVWDVRF | APHGYYFVSC | SYDKTARLWA | TDSNQALRVF | VGHLSDVDCV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QFHPNSNYVA | TGSSDRTVRL | WDNMTGQSVR | LMTGHKGSVS | SLAFSACGRY | LASGSVDHNI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IIWDLSNGSL | VTTLLRHTST | VTTITFSRDG | TVLAAAGLDN | NLTLWDFHKV | TEDYISNHIT |
| 670 | 680 | 690 | 700 | ||
| VSHHQDENDE | DVYLMRTFPS | KNSPFVSLHF | TRRNLLMCVG | LFKS |