P38129

PR
Gene name
TAF5 (TAF90, YBR198C, YBR1410)
Protein name
Transcription initiation factor TFIID subunit 5
Names
TAFII-90, TBP-associated factor 5, TBP-associated factor 90 kDa
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR198C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P38129

Entry ID Method Resolution Chain Position Source
2J49 X-ray 230 A A 147-290 PDB
6T9I EM 390 A D 1-798 PDB
6T9K EM 330 A D 1-798 PDB
AF-P38129-F1 Predicted AlphaFoldDB

12 variants for P38129

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-618419 34 G>S No SGRP
s02-618391 43 G>D No SGRP
s02-617645 292 A>T No SGRP
s02-617384 379 T>A No SGRP
s02-617360 387 I>L No SGRP
s02-617308 404 V>A No SGRP
s02-617291 410 D>N No SGRP
s02-617102 473 D>N No SGRP
s02-616718 601 P>S No SGRP
s02-616649 624 V>M No SGRP
s02-616555 655 I>T No SGRP
s02-616298 741 Y>D No SGRP

No associated diseases with P38129

11 regional properties for P38129

Type Name Position InterPro Accession
repeat WD40 repeat 455 - 503 IPR001680-1
repeat WD40 repeat 514 - 595 IPR001680-2
repeat WD40 repeat 598 - 731 IPR001680-3
domain LIS1 homology motif 56 - 88 IPR006594
domain TFIID subunit TAF5, NTD2 domain 148 - 283 IPR007582
conserved_site WD40 repeat, conserved site 624 - 638 IPR019775-1
conserved_site WD40 repeat, conserved site 666 - 680 IPR019775-2
conserved_site WD40 repeat, conserved site 709 - 723 IPR019775-3
repeat G-protein beta WD-40 repeat 540 - 554 IPR020472-1
repeat G-protein beta WD-40 repeat 624 - 638 IPR020472-2
repeat G-protein beta WD-40 repeat 709 - 723 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
SAGA complex A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
SLIK (SAGA-like) complex A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction.
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

4 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
identical protein binding Binding to an identical protein or proteins.
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

8 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone acetylation The modification of a histone by the addition of an acetyl group.
histone deubiquitination The modification of histones by removal of ubiquitin groups.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49846 Taf5 Transcription initiation factor TFIID subunit 5 Drosophila melanogaster (Fruit fly) PR
Q6S7B0 TAF5 Transcription initiation factor TFIID subunit 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSQKQSTNQN QNGTHQPQPV KNQRTNNAAG ANSGQQPQQQ SQGQSQQQGR SNGPFSASDL
70 80 90 100 110 120
NRIVLEYLNK KGYHRTEAML RAESGRTLTP QNKQSPANTK TGKFPEQSSI PPNPGKTAKP
130 140 150 160 170 180
ISNPTNLSSK RDAEGGIVSS GRLEGLNAPE NYIRAYSMLK NWVDSSLEIY KPELSYIMYP
190 200 210 220 230 240
IFIYLFLNLV AKNPVYARRF FDRFSPDFKD FHGSEINRLF SVNSIDHIKE NEVASAFQSH
250 260 270 280 290 300
KYRITMSKTT LNLLLYFLNE NESIGGSLII SVINQHLDPN IVESVTAREK LADGIKVLSD
310 320 330 340 350 360
SENGNGKQNL EMNSVPVKLG PFPKDEEFVK EIETELKIKD DQEKQLNQQT AGDNYSGANN
370 380 390 400 410 420
RTLLQEYKAM NNEKFKDNTG DDDKDKIKDK IAKDEEKKES ELKVDGEKKD SNLSSPARDI
430 440 450 460 470 480
LPLPPKTALD LKLEIQKVKE SRDAIKLDNL QLALPSVCMY TFQNTNKDMS CLDFSDDCRI
490 500 510 520 530 540
AAAGFQDSYI KIWSLDGSSL NNPNIALNNN DKDEDPTCKT LVGHSGTVYS TSFSPDNKYL
550 560 570 580 590 600
LSGSEDKTVR LWSMDTHTAL VSYKGHNHPV WDVSFSPLGH YFATASHDQT ARLWSCDHIY
610 620 630 640 650 660
PLRIFAGHLN DVDCVSFHPN GCYVFTGSSD KTCRMWDVST GDSVRLFLGH TAPVISIAVC
670 680 690 700 710 720
PDGRWLSTGS EDGIINVWDI GTGKRLKQMR GHGKNAIYSL SYSKEGNVLI SGGADHTVRV
730 740 750 760 770 780
WDLKKATTEP SAEPDEPFIG YLGDVTASIN QDIKEYGRRR TVIPTSDLVA SFYTKKTPVF
790
KVKFSRSNLA LAGGAFRP