Q6PEI3
Gene name |
phactr4b (zgc:63484) |
Protein name |
Phosphatase and actin regulator 4B |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:393643 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PEI3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PEI3-F1 | Predicted | AlphaFoldDB |
No variants for Q6PEI3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6PEI3 | |||||
No associated diseases with Q6PEI3
1 regional properties for Q6PEI3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 51 - 324 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| protein phosphatase 1 binding | Binding to a protein phosphatase 1. |
| protein phosphatase activator activity | Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| closure of optic fissure | The closure of the temporary ventral gap in the optic cup that contributes to its shaping. |
| enteric nervous system development | The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. |
| negative regulation of integrin-mediated signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway. |
| neural crest cell migration | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| neural tube closure | The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
| positive regulation of catalytic activity | Any process that activates or increases the activity of an enzyme. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| Rho protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MENRDDEVEH | QHSTMGSEGG | TAGDGTPPPK | RKGKFSTLGK | IFKPWKWRKK | KSSEKFKETS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVLERKMSMR | RPRQELIEQG | VLKELPDNES | GEAHGHKAPY | VKNGHTLPVG | VGGSLALEQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSPSESEFRI | NPVWLPQPED | RRARAPSDGD | HRGALGPRAS | NQDDGRRGGW | SVGTEDWKNN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAWHGEDIRR | GGRAHAEMDK | RPGLMKAPSE | DGRRTRPEPD | WKPTLPRHSS | VEEGRGRRES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DSSQYLPNSE | MMRDTLREPL | PPKQSIMPPK | WLMTSTPEPG | SDSLPRTPVH | NPAAPSFCSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSSSSSSAGK | PLRNVSSAGA | NTAPPGGAPL | TTSSAPCSMG | TIPNHPSKQP | PMPPPKPINR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNNPAIMAEL | TQGGMNLVPA | KPSPPMPPKR | TTPVTKRNPE | DSPLTIASLP | SILSEDMRAN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IPGGYQLPPP | PPSPPLPTHI | PPSPPRAHTH | HLLHQHSYPY | PLPQPLPVHF | DPPSPPEDPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ARDEDDYSDE | EEEEEDDEDD | EEPPPDHLPS | PQSQPELEPR | SRRCLVGELS | VSVIPEGNNS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEEEEDEEDQ | HPEESDSDGP | VLYKDDESDE | DEEDDSPPSA | LASRVKRKDT | LALKLSSRPS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| APDRQAPERQ | AKSEHSGLSW | QSKEQWEAIR | TQIGTALTRR | LSQRPTAEEL | EQRNILQPKN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EADRQAEVRE | IKRRLTRKLS | QRPTVAELQA | RKILRFHEYV | EVTSAQDYDR | RADKPWTKLT |
| 730 | 740 | 750 | |||
| PADKAAIRKE | LNEFKSSEME | VHEESRIYTR | FHRP |