P33304
Gene name |
AFR1 (YDR085C, D4471) |
Protein name |
Protein AFR1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR085C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P33304
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P33304-F1 | Predicted | AlphaFoldDB |
29 variants for P33304
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-616138 | 4 | S>T | No | SGRP | |
| s04-615972 | 59 | S>N | No | SGRP | |
| s04-615970 | 60 | G>S | No | SGRP | |
| s04-615813 | 112 | S>N | No | SGRP | |
| s04-615795 | 118 | Q>R | No | SGRP | |
| s04-615732 | 139 | R>T | No | SGRP | |
| s04-615691 | 153 | L>I | No | SGRP | |
| s04-615646 | 168 | S>P | No | SGRP | |
| s04-615627 | 174 | F>C | No | SGRP | |
| s04-615577 | 191 | P>S | No | SGRP | |
| s04-615445 | 235 | V>I | No | SGRP | |
| s04-615316 | 278 | L>M | No | SGRP | |
| s04-615316 | 278 | L>V | No | SGRP | |
| s04-615255 | 298 | K>R | No | SGRP | |
| s04-615244 | 302 | I>V | No | SGRP | |
| s04-615240 | 303 | L>P | No | SGRP | |
| s04-615222 | 309 | R>K | No | SGRP | |
| s04-615205 | 315 | S>P | No | SGRP | |
| s04-615111 | 346 | R>K | No | SGRP | |
| s04-615092 | 352 | M>I | No | SGRP | |
| s04-615057 | 364 | N>S | No | SGRP | |
| s04-615041 | 369 | M>I | No | SGRP | |
| s04-614937 | 404 | L>S | No | SGRP | |
| s04-614661 | 496 | P>Q | No | SGRP | |
| s04-614662 | 496 | P>S | No | SGRP | |
| s04-614610 | 513 | N>T | No | SGRP | |
| s04-614452 | 566 | A>T | No | SGRP | |
| s04-614430 | 573 | N>S | No | SGRP | |
| s04-614428 | 574 | R>C | No | SGRP |
No associated diseases with P33304
No regional properties for P33304
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P33304 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mating projection base | The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cell morphogenesis involved in conjugation with cellular fusion | The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion. |
| protein localization to bud neck | A process in which a protein is transported to, or maintained at, a location within a cellular bud neck. |
| septin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IZ21 | PHACTR4 | Phosphatase and actin regulator 4 | Homo sapiens (Human) | PR |
| Q9C0D0 | PHACTR1 | Phosphatase and actin regulator 1 | Homo sapiens (Human) | PR |
| Q2M3X8 | Phactr1 | Phosphatase and actin regulator 1 | Mus musculus (Mouse) | PR |
| P62024 | Phactr1 | Phosphatase and actin regulator 1 | Rattus norvegicus (Rat) | PR |
| Q6PEI3 | phactr4b | Phosphatase and actin regulator 4B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGSYLSAQE | NQPIPERLIP | RSNSTSNLFA | LSSTFSKLNV | RNDADYNYSN | PNKKRHIYSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIDCRSVTAA | RKFPVRSCSM | TAAQQRKRTA | LFTVRERNSY | HEGFNNDQDY | VSQYQKPQYT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FGVYKELTPY | QLQRSKMKRS | FQFPNGEIYK | PKLDGKCTHS | LKKPELNSRD | SSLFKFSEKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GRNLSKDFVG | PHNGTSVIHI | PPNDTGYGVN | SLELNTSVPS | TIKSSVSSTS | PISAVNTLTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPESQTDDDD | GYENKTVTIS | YCFENTVNEK | HGSHIEKLDL | STKEKTKPTT | NSGLFDRKKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TILGTEKYRC | IKSQSKLKLG | SVLKKLWRTS | GNSNTKHGKK | DTKRRRIPID | DMVTHSDGNS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAENDIELMD | ANLDGIEFDD | DETLMDTDSI | FDDLLSKEND | KYDLRRRQLE | IRQKLHETSH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NDDGKVSFRD | TEKHNVNEGL | IDKTIIEEFS | KLGEYIIDTR | NQPPPRSSKR | PSLDDNESAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YFYNISTDLR | QSLSGPISLP | MHVGNDMVNR | LRNDWEYIRF | EDRRNSLPDS | SFDKVETPPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PIKKDVRFAK | EVCLASTWSS | NAYERANPEF | IMNRHRLLWM | MKVHPSMNSA | MNEIKLELNS |
| 610 | |||||
| YKKNEMVVHE | NSKCFTHYLI |