Q2M3X8
PR
Gene name |
Phactr1 |
Protein name |
Phosphatase and actin regulator 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:218194 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
24 variants for Q2M3X8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389279238 | 41 | L>F | No | EVA | |
| rs3389276176 | 54 | D>V | No | EVA | |
| rs3389253274 | 73 | A>P | No | EVA | |
| rs3389263589 | 78 | S>Y | No | EVA | |
| rs3389272990 | 80 | N>K | No | EVA | |
| rs3389263588 | 130 | S>G | No | EVA | |
| rs3389280211 | 138 | A>S | No | EVA | |
| rs3389208558 | 141 | E>G | No | EVA | |
| rs3389208539 | 142 | R>K | No | EVA | |
| rs3389277359 | 145 | S>T | No | EVA | |
| rs3413117599 | 159 | L>S | No | EVA | |
| rs3389253259 | 176 | D>N | No | EVA | |
| rs3389280210 | 208 | S>P | No | EVA | |
| rs3389288873 | 242 | P>Q | No | EVA | |
| rs3412243596 | 266 | S>I | No | EVA | |
| rs3389296118 | 273 | Q>H | No | EVA | |
| rs3389272946 | 275 | H>L | No | EVA | |
| rs3404168074 | 320 | L>H | No | EVA | |
| rs3389253323 | 368 | V>L | No | EVA | |
| rs3389279173 | 377 | E>D | No | EVA | |
| rs3389281247 | 416 | M>K | No | EVA | |
| rs3389276224 | 440 | K>E | No | EVA | |
| rs3389276194 | 562 | S>C | No | EVA | |
| rs3389288870 | 570 | L>F | No | EVA |
No associated diseases with Q2M3X8
1 regional properties for Q2M3X8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 147 - 416 | IPR017452 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| protein phosphatase 1 binding | Binding to a protein phosphatase 1. |
| protein phosphatase inhibitor activity | Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
| cell motility | Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. |
| cerebral cortex development | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. |
| dendrite arborization | The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches. |
| regulation of neuron migration | Any process that modulates the frequency, rate or extent of neuron migration. |
| regulation of phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. |
| stress fiber assembly | The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33304 | AFR1 | Protein AFR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9C0D0 | PHACTR1 | Phosphatase and actin regulator 1 | Homo sapiens (Human) | PR |
| Q8IZ21 | PHACTR4 | Phosphatase and actin regulator 4 | Homo sapiens (Human) | PR |
| P62024 | Phactr1 | Phosphatase and actin regulator 1 | Rattus norvegicus (Rat) | PR |
| Q6PEI3 | phactr4b | Phosphatase and actin regulator 4B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDYPKMDYFL | DVESAHRLLD | VESAQRFFYS | QGAQARRATL | LLPPTLMAAS | SEDDIDRRPI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRVRSKSDTP | YLAEARISFN | LGAAEEVERL | AAMRSDSLVP | GTHTPPIRRR | SKFANLGRIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPWKWRKKKS | EKFKHTSAAL | ERKISMRQSR | EELIKRGVLK | EIYDKDGELS | ISNEDDSLEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GQSLSSSQLS | LPALSEMEPV | PMPRDPCSYE | VLQASDIMDG | PDPGAPVKLP | CLPVKLSPPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPKKVLICMP | VGGPELTLAS | YAAQKSSQQA | VAQHHHTVLP | SQMQHQLQYG | SHGQHLPSST |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTLPMHPSGC | RMIDELNKTL | AMTMQRLESS | EQRVPCSTSY | HSSGLHSSDG | ITKAGPMGLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EIRQVPTVVI | ECDDNKENVP | HEPDYEDSPC | LYGREEEEEE | EDEDDDASLY | TSSLAMKVCR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KDSLAIKLSN | RPSKRELEEK | NILPRQTDEE | RLELRQQIGT | KLTRRLSQRP | TAEELEQRNI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKPRNEQEEQ | EEKREIKRRL | TRKLSQRPTV | EELRERKILI | RFSDYVEVAD | AQDYDRRADK |
| 550 | 560 | 570 | |||
| PWTRLTAADK | AAIRKELNEF | KSTEMEVHEL | SRHLTRFHRP |