AiPD: Autoinhibited Protein Database

Gene name	Ppp4r3a
Protein name	Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Names	SMEK homolog 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:68734
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

81-162 (Predicted disordered autoinhibitory region) PR

81-162 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6P2K6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389222776	42	V>A	No	EVA
rs3389255405	93	I>V	No	EVA
rs218363045	108	D>E	No	EVA
rs3389251935	112	D>E	No	EVA
rs3389263480	114	V>I	No	EVA
rs3389240352	135	C>Y	No	EVA
rs3389263453	139	R>Q	No	EVA
rs3389254405	144	A>P	No	EVA
rs3389187231	150	S>P	No	EVA
rs3403708699	170	I>M	No	EVA
rs3402924590	174	L>*	No	EVA
rs3403652680	175	E>K	No	EVA
rs3389249004	176	L>P	No	EVA
rs3389240430	177	F>C	No	EVA
rs3403623242	178	H>N	No	EVA
rs3389222852	182	D>*	No	EVA
rs3389213969	183	L>W	No	EVA
rs3389187235	242	K>*	No	EVA
rs3389222791	244	A>P	No	EVA
rs3389251967	252	I>L	No	EVA
rs3389264669	260	K>E	No	EVA
rs3389222845	269	Y>*	No	EVA
rs3389251991	272	D>G	No	EVA
rs3389256679	272	D>N	No	EVA
rs3389258551	294	F>L	No	EVA
rs1134221966	319	T>K	No	EVA
rs1131767157	325	E>Q	No	EVA
rs32969052	375	T>A	No	EVA
rs3389256723	526	R>*	No	EVA
rs3389213935	527	V>M	No	EVA
rs3389251998	666	E>VSDG*	No	EVA
rs3389249016	669	W>C	No	EVA
rs3389263396	672	T>I	No	EVA
rs3389256690	674	E>G	No	EVA
rs3389269440	690	T>P	No	EVA
rs3389264644	700	I>V	No	EVA
rs3389240361	785	G>*	No	EVA
rs3389240405	787	L>V	No	EVA
rs3389249013	788	V>G	No	EVA
rs3403707779	802	E>Q	No	EVA
rs3389228512	817	K>E	No	EVA

Type	Name	Position	InterPro Accession
domain	Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain	166 - 357	IPR006887

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus	In interphase localized in the cytoplasm and in the nucleus (with higher levels) During metaphase located in pericentriolar regions (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase 4 complex	A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.

Name	Definition
protein phosphatase activator activity	Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
gluconeogenesis	The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
positive regulation of gluconeogenesis	Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6IN85	PPP4R3A	Serine/threonine-protein phosphatase 4 regulatory subunit 3A	Homo sapiens (Human)	PR
Q6DFT3	ppp4r3b	Serine/threonine-protein phosphatase 4 regulatory subunit 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR