AiPD: Autoinhibited Protein Database

Q6IN85

Gene name	PPP4R3A
Protein name	Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Names	SMEK homolog 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55671
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-160 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

82-160 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q6IN85

Entry ID	Method	Resolution	Chain	Position	Source
6R8I	X-ray	152 A	A	1-117	PDB
AF-Q6IN85-F1	Predicted				AlphaFoldDB

366 variants for Q6IN85

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs765108460 CA7311060	5	R>Q		No	ClinGen ExAC gnomAD
CA390634604 rs1313747322	5	R>W		No	ClinGen gnomAD
rs950227605 CA265558414	8	V>G		No	ClinGen Ensembl
TCGA novel	9	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390634550 rs1350272476	9	K>R		No	ClinGen gnomAD
rs774324266 CA7311055	12	T>M		No	ClinGen ExAC TOPMed gnomAD
CA7311053 rs763429914	13	L>F		No	ClinGen ExAC gnomAD
TCGA novel	21	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770515342 CA7311048	28	S>L		No	ClinGen ExAC gnomAD
rs1006713516 CA265558364	30	G>S		No	ClinGen TOPMed
CA390634219 rs1308779029	35	L>Q		No	ClinGen gnomAD
CA390634215 rs1308779029	35	L>R		No	ClinGen gnomAD
CA390634178 rs1331261315	38	M>L		No	ClinGen TOPMed
CA265558331 rs200747494	39	S>C		No	ClinGen 1000Genomes ExAC gnomAD
rs200747494 CA390634156	39	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA7311044 rs200747494	39	S>Y		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	40	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402932705 CA390634114	43	R>K		No	ClinGen gnomAD
CA390634099 rs1308910988	44	A>S		No	ClinGen TOPMed gnomAD
CA390634073 rs1169758979	46	S>G		No	ClinGen gnomAD
CA390634066 rs1434262934	46	S>N		No	ClinGen gnomAD
CA390634055 rs1197882486	47	D>N		No	ClinGen gnomAD
TCGA novel	52	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201169979 CA390628953	52	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1363552449 CA390628936	54	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7311006 rs761101764	60	T>I		No	ClinGen ExAC gnomAD
rs1223030716 CA390628708	68	T>A		No	ClinGen gnomAD
rs908206251 CA265536150	77	N>S		No	ClinGen TOPMed
CA265536132 rs759120978	89	G>V		No	ClinGen Ensembl
CA390628221 rs1324778079	95	E>A		No	ClinGen gnomAD
CA7310962 rs751192835	107	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1049300288 CA265533744	109	I>M		No	ClinGen TOPMed
rs1177105600 CA390626572	109	I>V		No	ClinGen gnomAD
rs1198339093 CA390626472	114	V>M		No	ClinGen gnomAD
rs1455405600 CA390626427	116	E>K		No	ClinGen TOPMed
rs751288688 CA265533740	116	E>V		No	ClinGen Ensembl
CA390626412 rs1470388848	117	S>Y		No	ClinGen gnomAD
rs752287387 CA7310959	121	R>H		No	ClinGen ExAC gnomAD
CA7310958 rs764698174	125	M>L		No	ClinGen ExAC gnomAD
rs759497847 CA7310957	125	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	125	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1321945223 CA390626247	127	S>L		No	ClinGen gnomAD
rs1321945223 CA390626249	127	S>W		No	ClinGen gnomAD
TCGA novel	128	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390626222 rs1224740650	129	G>A		No	ClinGen gnomAD
TCGA novel	134	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs78124650 CA265533681	135	C>S		No	ClinGen Ensembl
TCGA novel	137	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7310953 rs768951187	139	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs768951187 CA7310952	139	R>L		No	ClinGen ExAC gnomAD
rs780157659 CA7310950	146	L>V		No	ClinGen ExAC TOPMed gnomAD
rs746372581 CA7310948	147	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7310946 rs757637900	154	P>S		No	ClinGen ExAC gnomAD
CA390625879 rs1409851996	156	R>H		No	ClinGen gnomAD
rs1171077154 CA390625862	157	R>C		No	ClinGen gnomAD
rs751996385 CA7310945	157	R>H		No	ClinGen ExAC gnomAD
CA390625812 rs1567154553	159	K>R		No	ClinGen Ensembl
rs1460024126 CA390625688	165	E>D		No	ClinGen gnomAD
CA390625627 rs1319137050	167	E>D		No	ClinGen gnomAD
CA390625645 rs1243118522	167	E>K	Variant assessed as Somatic; 0.0001848 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7310942 rs752344182	167	E>V		No	ClinGen ExAC TOPMed gnomAD
CA390625619 rs935835317	168	G>C		No	ClinGen TOPMed gnomAD
CA390625617 rs1180395101	168	G>D		No	ClinGen TOPMed
CA265533573 rs935835317	168	G>R		No	ClinGen TOPMed gnomAD
rs1282534136 CA390625605	169	Y>D		No	ClinGen TOPMed gnomAD
CA390625591 rs1282534136	169	Y>H		No	ClinGen TOPMed gnomAD
CA7310941 rs764794753	170	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1352440378 CA390625538	171	K>R		No	ClinGen gnomAD
rs760418868 CA7310937	178	H>R		No	ClinGen ExAC TOPMed gnomAD
CA7310938 rs200456384	178	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7310935 rs771809496	179	V>A		No	ClinGen ExAC gnomAD
CA390625357 rs1158064030	179	V>M		No	ClinGen TOPMed
TCGA novel	180	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775640436 CA390625280	183	L>M		No	ClinGen ExAC TOPMed gnomAD
rs769845796 CA7310932	183	L>S		No	ClinGen ExAC TOPMed gnomAD
CA7310933 rs775640436	183	L>V		No	ClinGen ExAC TOPMed gnomAD
rs745959269 CA7310931	185	N>S		No	ClinGen ExAC gnomAD
rs781746912 CA7310930	186	I>T		No	ClinGen ExAC gnomAD
TCGA novel	187	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770307956 CA7310928	189	L>QV*		No	ClinGen ExAC
CA265533479 rs376796437	192	L>F		No	ClinGen ESP TOPMed gnomAD
CA265533464 rs373332248	193	Y>C		No	ClinGen ESP TOPMed
rs771597992 CA7310927	193	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	194	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	194	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775499610 CA265533458	195	I>L		No	ClinGen Ensembl
CA390625107 rs1215606759	195	I>T		No	ClinGen gnomAD
rs775499610 CA390625111	195	I>V		No	ClinGen Ensembl
rs1349110500 CA390625076	197	K>R		No	ClinGen TOPMed
rs1228391484 CA390625048	199	I>S		No	ClinGen TOPMed
CA390625022 rs1292115993	201	L>I		No	ClinGen gnomAD
CA7310925 rs778179619	204	R>Q		No	ClinGen ExAC gnomAD
rs758752190 CA7310924	206	A>T		No	ClinGen ExAC gnomAD
CA390624919 rs1287028931	209	E>K		No	ClinGen gnomAD
rs1323035299 CA390624789	218	M>L		No	ClinGen gnomAD
rs1323035299 CA390624788	218	M>V		No	ClinGen gnomAD
CA390624755 rs756021186	219	D>E		No	ClinGen ExAC TOPMed gnomAD
CA7310919 rs765911270	219	D>G		No	ClinGen ExAC gnomAD
CA265533392 rs886135544	220	V>A		No	ClinGen TOPMed gnomAD
rs750383941 CA7310917	220	V>I		No	ClinGen ExAC gnomAD
CA7310916 rs767339965	221	I>T		No	ClinGen ExAC TOPMed gnomAD
CA7310913 rs533591917	226	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1224284352 CA390624615	227	D>E		No	ClinGen TOPMed gnomAD
rs759650627 CA7310912	227	D>G		No	ClinGen ExAC gnomAD
CA7310911 rs776823120	231	S>L		No	ClinGen ExAC gnomAD
rs771187036 CA7310910	232	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA390624534 rs1420697845	233	P>A		No	ClinGen TOPMed
CA390624516 rs1204669997	234	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs374959471 CA265533335	238	E>V		No	ClinGen ESP
rs78875778 CA265533334	241	T>K		No	ClinGen Ensembl
TCGA novel	243	T>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390624403 rs1293395184	244	A>S		No	ClinGen gnomAD
CA7310908 rs773664066	245	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	248	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA265533317 rs879003474	252	I>M		No	ClinGen Ensembl
TCGA novel	260	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	262	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1352814952 CA390623799	273	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7310904 rs754591155	273	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7310903 rs748987963	276	P>R		No	ClinGen ExAC gnomAD
rs1470565172 CA390623734	277	T>A		No	ClinGen gnomAD
TCGA novel	278	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7310902 rs779523621	279	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1312920705 CA390623493	288	T>R		No	ClinGen TOPMed
rs867665153 CA390623470	290	H>N		No	ClinGen gnomAD
rs867665153 CA265533275	290	H>Y		No	ClinGen gnomAD
CA7310900 rs750307811	292	F>L		No	ClinGen ExAC gnomAD
CA7310898 rs757028562	293	I>V		No	ClinGen ExAC gnomAD
CA390621697 rs1325330384	309	K>E		No	ClinGen gnomAD
rs1290942967 CA390621646	312	T>I		No	ClinGen gnomAD
CA7310881 rs781144838	317	Q>H		No	ClinGen ExAC gnomAD
CA390621549 rs1157643037	319	T>I		No	ClinGen gnomAD
CA390621501 rs1386506625	323	T>A		No	ClinGen gnomAD
CA7310879 rs751566194	324	D>V		No	ClinGen ExAC gnomAD
rs975008935 CA265530168	326	E>D		No	ClinGen TOPMed
CA390621433 rs1441704692	328	R>G		No	ClinGen gnomAD
CA7310859 rs780547287	332	V>I		No	ClinGen ExAC gnomAD
CA390621002 rs1201806768	334	F>L		No	ClinGen TOPMed
rs746918216 CA7310857	338	F>L		No	ClinGen ExAC gnomAD
rs777862008 CA7310856	339	C>F		No	ClinGen ExAC gnomAD
rs758213999 CA7310855	340	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA390620849 rs1463941060	344	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1171310106 CA390620846	345	L>Q		No	ClinGen TOPMed
rs1373545401 CA390620822	348	Q>H		No	ClinGen TOPMed
CA390620793 rs1431605008	352	A>G		No	ClinGen TOPMed
rs756265570 CA7310852	354	F>L		No	ClinGen ExAC TOPMed gnomAD
CA7310851 rs750713194	357	L>M		No	ClinGen ExAC gnomAD
rs1198398439 CA390620751	358	S>L		No	ClinGen gnomAD
CA390620741 rs1405335769	360	M>V		No	ClinGen TOPMed
TCGA novel	362	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376854978 CA7310847	362	I>V		No	ClinGen ExAC gnomAD
CA390620709 rs1294860116	364	P>L		No	ClinGen TOPMed
CA7310846 rs763263594	368	V>L		No	ClinGen ExAC gnomAD
TCGA novel	371	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758881648 CA7310822	372	M>I		No	ClinGen ExAC TOPMed gnomAD
rs983822366 CA265529352	372	M>T		No	ClinGen TOPMed gnomAD
rs753263157 CA7310821	373	D>G		No	ClinGen ExAC gnomAD
CA390620644 rs1337336412	373	D>N		No	ClinGen gnomAD
rs765517627 CA390620631 CA7310820	374	D>E		No	ClinGen ExAC gnomAD
rs140684085 CA390620608	378	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs140684085 CA7310819	378	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA390620601 rs1595062053	379	S>N		No	ClinGen Ensembl
CA7310818 rs776093984	382	T>I		No	ClinGen ExAC TOPMed gnomAD
rs766082516 CA7310817	384	I>M		No	ClinGen ExAC gnomAD
rs1157047022 CA390620564	384	I>T		No	ClinGen gnomAD
rs754204744 CA265529289	384	I>V		No	ClinGen Ensembl
TCGA novel	387	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390620497 rs1185972729	389	V>A		No	ClinGen gnomAD
CA265529273 rs959473713	390	E>D		No	ClinGen gnomAD
CA390620420 rs1217042715	395	M>T		No	ClinGen gnomAD
rs760440115 CA7310816	395	M>V		No	ClinGen ExAC gnomAD
TCGA novel	398	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150940624 CA7310815	398	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs748091651 CA7310813	401	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7310812 rs774347968	402	Q>L		No	ClinGen ExAC gnomAD
TCGA novel	406	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7310811 rs372384377	407	N>S		No	ClinGen ESP ExAC gnomAD
CA390620150 rs1567151518	408	D>N		No	ClinGen Ensembl
CA390620136 rs1376958785	409	D>N		No	ClinGen gnomAD
rs749129628 CA7310810	418	K>N		No	ClinGen ExAC gnomAD
CA265529245 rs766599822	419	I>M		No	ClinGen Ensembl
rs1198163763 CA390619817	421	S>N		No	ClinGen TOPMed
rs952737840 CA265526788	423	D>G		No	ClinGen TOPMed
CA7310777 rs780559000	423	D>N		No	ClinGen ExAC gnomAD
CA7310776 rs143493713	424	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs767298918 CA7310774	425	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1025873617 CA390618709	427	I>M		No	ClinGen TOPMed gnomAD
rs912288691 CA265526752	428	N>S		No	ClinGen gnomAD
rs1453477370 CA390618661	430	I>F		No	ClinGen TOPMed
rs751049083 CA7310772	433	H>Q		No	ClinGen ExAC gnomAD
rs1453949515 CA390618495	438	T>K		No	ClinGen gnomAD
rs763562211 CA7310771	440	P>A		No	ClinGen ExAC TOPMed gnomAD
rs201007128 CA265526727	442	L>F		No	ClinGen 1000Genomes
rs762935380 CA7310770	448	L>F		No	ClinGen ExAC gnomAD
CA265526722 rs200834500	450	G>R		No	ClinGen Ensembl
CA7310767 rs759343277	453	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1292921882 CA390618254	456	V>I		No	ClinGen TOPMed
rs1595059474 CA390618237	457	D>A		No	ClinGen Ensembl
CA390618171 rs1177941808	461	M>I		No	ClinGen gnomAD
CA7310765 rs61752313	466	N>S		No	ClinGen ExAC TOPMed gnomAD
CA390618064 rs1465687620	467	K>R		No	ClinGen Ensembl
CA390618009 rs1172954665	471	T>S		No	ClinGen Ensembl
rs762031947 CA7310746	475	G>A		No	ClinGen ExAC gnomAD
CA390617919 rs1398530708	476	F>Y		No	ClinGen gnomAD
CA7310743 rs749378173	479	K>N		No	ClinGen ExAC gnomAD
CA390617847 rs770385675	480	H>Q		No	ClinGen ExAC gnomAD
rs776110952 CA7310742	480	H>R		No	ClinGen ExAC gnomAD
rs1376343335 CA390617773	484	V>I		No	ClinGen TOPMed
CA7310740 rs746399518	486	T>I		No	ClinGen ExAC gnomAD
CA390617614 rs1476702233	494	T>A		No	ClinGen gnomAD
rs1199795807 CA390617602	495	E>K		No	ClinGen gnomAD
CA7310738 rs757566591	500	K>T		No	ClinGen ExAC gnomAD
CA7310720 rs771311249	503	F>V		No	ClinGen ExAC gnomAD
rs1317806903 CA390617418	504	Q>H		No	ClinGen TOPMed
rs533898148 CA265524695	508	L>V		No	ClinGen 1000Genomes
rs1219458748 CA390617377	511	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA390617272 rs1450307807	519	C>F		No	ClinGen TOPMed
CA7310719 rs747379927	521	E>D		No	ClinGen ExAC gnomAD
CA7310717 rs757944827	528	K>R		No	ClinGen ExAC gnomAD
CA390617077 rs1567148879	531	I>V		No	ClinGen Ensembl
rs778331899 CA7310715	538	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	538	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595056842 CA390616876	540	V>A		No	ClinGen Ensembl
rs1399292270 CA390616867	541	L>V		No	ClinGen gnomAD
rs766278446 CA7310712	544	M>T		No	ClinGen ExAC TOPMed gnomAD
rs755909017 CA7310711	545	A>T		No	ClinGen ExAC gnomAD
TCGA novel	546	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	560	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761024848 CA7310681	563	I>L		No	ClinGen ExAC gnomAD
TCGA novel	568	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390615331 rs1400363234	572	R>C		No	ClinGen gnomAD
CA7310676 rs768259398	579	L>F		No	ClinGen ExAC gnomAD
rs745788259 CA7310672	585	K>T		No	ClinGen ExAC TOPMed gnomAD
CA7310671 rs781247545	586	A>T		No	ClinGen ExAC TOPMed gnomAD
CA390615120 rs1171916182	586	A>V		No	ClinGen gnomAD
rs757094294 CA7310670	589	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7310669 rs536770708	590	N>D		No	ClinGen 1000Genomes ExAC gnomAD
CA390615093 rs1460657977	590	N>S		No	ClinGen TOPMed
rs777739532 CA7310668	591	G>R		No	ClinGen ExAC gnomAD
rs1485276355 CA390615080	592	S>P		No	ClinGen gnomAD
rs1485276355 CA390615077	592	S>T		No	ClinGen gnomAD
rs1246714322 CA390615061	593	R>H		No	ClinGen gnomAD
rs1398570794 CA390633549	613	I>V		No	ClinGen gnomAD
CA390633514 rs1595048268	618	A>S		No	ClinGen Ensembl
CA390633500 rs1298018688	620	V>I		No	ClinGen gnomAD
rs756118736 CA7310643	622	E>G		No	ClinGen ExAC gnomAD
rs757704936 CA7310640	630	D>N		No	ClinGen ExAC gnomAD
rs372908590 CA7310639	632	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	633	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763432828 CA7310637	634	V>I		No	ClinGen ExAC gnomAD
TCGA novel	640	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390633306 rs1488985228	641	K>N		No	ClinGen TOPMed
rs774983570 CA390633303	642	L>M		No	ClinGen ExAC gnomAD
CA7310636 rs774983570	642	L>V		No	ClinGen ExAC gnomAD
CA7310635 rs764979244	644	F>L		No	ClinGen ExAC gnomAD
CA390633273 rs1483443992	644	F>S		No	ClinGen gnomAD
CA7310633 rs776229776	651	Q>*		No	ClinGen ExAC gnomAD
rs1263168352 CA390633171	652	D>N		No	ClinGen Ensembl
rs1286753004 CA390633154	653	N>D		No	ClinGen gnomAD
CA7310632 rs770575828	653	N>S		No	ClinGen ExAC gnomAD
rs1375412717 CA390633140	654	P>S		No	ClinGen gnomAD
CA7310631 rs746871715	656	L>F		No	ClinGen ExAC gnomAD
CA390633098 rs1381733049	657	D>E		No	ClinGen TOPMed gnomAD
rs370036690 CA7310614	660	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1354471306 CA390632536	662	I>L		No	ClinGen gnomAD
rs918863379 CA265562921	662	I>M		No	ClinGen gnomAD
rs765980139 CA7310613	665	N>D		No	ClinGen ExAC gnomAD
CA390632477 rs1422204562	666	H>R		No	ClinGen TOPMed
CA390632465 rs1382095599	667	R>K		No	ClinGen gnomAD
CA265562912 rs935361912	669	R>Q		No	ClinGen TOPMed gnomAD
rs1370102345 CA390632393	671	D>V		No	ClinGen gnomAD
rs1567144474 CA390632143	681	M>I		No	ClinGen Ensembl
rs1210498171 CA390631925	690	M>V		No	ClinGen gnomAD
rs774139925 CA7310607	691	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1297849503 CA390631819	695	A>G		No	ClinGen TOPMed
rs768342743 CA7310606	695	A>P		No	ClinGen ExAC TOPMed gnomAD
CA390631767 rs1318983606	698	S>P		No	ClinGen gnomAD
rs180892588 CA7310604	702	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7310603 rs770975042	705	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1567144432 CA390631521	709	I>L		No	ClinGen Ensembl
rs970991898 CA265562809	710	M>R		No	ClinGen Ensembl
rs747131542 CA7310600	711	D>G		No	ClinGen ExAC gnomAD
rs1567144421 CA390631416	713	I>M		No	ClinGen Ensembl
CA7310598 rs758888383	716	F>Y		No	ClinGen ExAC gnomAD
rs780589967 CA7310575	722	L>S		No	ClinGen ExAC gnomAD
rs1271878301 CA390631101	723	K>N		No	ClinGen gnomAD
CA390631083 rs1349421784	725	S>G		No	ClinGen TOPMed gnomAD
rs1277497308 CA390631044	727	E>G		No	ClinGen TOPMed gnomAD
rs1232926138 CA390631017	728	K>N		No	ClinGen gnomAD
TCGA novel	728	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755772710 CA7310574	730	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	731	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1335114165 CA390630899	734	T>R		No	ClinGen gnomAD
TCGA novel	735	N>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7310570 rs751492645	736	L>P		No	ClinGen ExAC gnomAD
rs201851813 CA265562287	737	S>C		No	ClinGen Ensembl
CA7310569 rs763976950	738	G>R		No	ClinGen ExAC gnomAD
CA7310568 rs762908427	739	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA390630825 rs1173163762	739	R>W		No	ClinGen TOPMed gnomAD
CA7310567 rs757937284	741	S>I		No	ClinGen ExAC TOPMed gnomAD
CA265562264 rs757937284	741	S>T		No	ClinGen ExAC TOPMed gnomAD
CA7310566 rs765029180	742	P>R		No	ClinGen ExAC
rs889764726 CA265562240	744	F>L		No	ClinGen TOPMed gnomAD
rs1486480970 CA390630683	750	S>G		No	ClinGen gnomAD
rs1384327040 CA390630677	750	S>T		No	ClinGen TOPMed
rs141774507 CA7310564	752	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA7310562 rs202092029	753	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1221939886 CA390630621	754	T>I		No	ClinGen gnomAD
CA7310561 rs774525152	755	N>H		No	ClinGen ExAC
rs1349709630 CA390630613	755	N>T		No	ClinGen gnomAD
rs749829204 CA7310559	756	L>P		No	ClinGen ExAC gnomAD
rs756614479 CA7310557	757	T>P		No	ClinGen ExAC gnomAD
rs1289007710 CA390630562	759	Q>R		No	ClinGen TOPMed
CA7310556 rs535877362	760	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7310555 rs780757822	760	S>L		No	ClinGen ExAC gnomAD
rs149860251 CA7310554	762	T>A		No	ClinGen ESP ExAC gnomAD
rs1037612500 CA265562162	763	T>A		No	ClinGen gnomAD
rs750993627 CA7310553	763	T>R		No	ClinGen ExAC gnomAD
CA390630511 rs763617268	764	N>H		No	ClinGen ExAC TOPMed gnomAD
CA390630506 rs1415242026	764	N>S		No	ClinGen gnomAD
CA7310552 rs763617268	764	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs752631714 CA390630497	765	L>M		No	ClinGen ExAC TOPMed gnomAD
CA7310549 rs371876416	765	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA390630474 rs759382262	767	G>R		No	ClinGen ExAC TOPMed gnomAD
rs759382262 CA7310548	767	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7310547 rs773458405	769	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1332341494 CA390630434	770	G>A		No	ClinGen gnomAD
CA265562092 rs918181214	772	P>A		No	ClinGen gnomAD
rs774242522 CA7310544	773	G>R		No	ClinGen ExAC
TCGA novel	776	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7310543 rs768864624	776	G>E		No	ClinGen ExAC gnomAD
rs1378090946 CA390630340	778	P>L		No	ClinGen TOPMed
CA7310542 rs201142813	779	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA390630320 rs776197370	780	S>C		No	ClinGen ExAC TOPMed gnomAD
CA7310541 rs776197370	780	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs139686419 CA7310535	784	V>I		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs139686419 CA265562051	784	V>L		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs756809008 CA7310533	785	P>S		No	ClinGen ExAC
rs746687953 CA7310532	787	N>S		No	ClinGen ExAC TOPMed gnomAD
rs573892996 CA7310530	791	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7310528 rs778869091	792	A>V		No	ClinGen ExAC gnomAD
rs1272249421 CA390630158	794	I>T		No	ClinGen gnomAD
CA7310527 rs754768561	794	I>V		No	ClinGen ExAC gnomAD
rs753530016 CA7310526	796	T>A		No	ClinGen ExAC gnomAD
CA390630137 rs1309464900	796	T>R		No	ClinGen TOPMed
rs189558489 CA7310504	801	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7310505 rs189558489	801	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1394428127 CA390629154	809	D>E		No	ClinGen gnomAD
rs200723204 CA7310501	811	E>D		No	ClinGen ESP TOPMed
CA390629128 rs1420661348	813	D>G		No	ClinGen gnomAD
CA7310500 rs150626793	813	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs753823528 CA7310499	814	D>E		No	ClinGen ExAC gnomAD
rs1176401615 CA390629122	814	D>H		No	ClinGen gnomAD
CA7310494 rs779713377	816	D>A		No	ClinGen ExAC
CA390629096 rs1259842446	817	E>V		No	ClinGen gnomAD
rs989940377 CA390629093	818	D>N		No	ClinGen gnomAD
rs989940377 CA265559430	818	D>Y		No	ClinGen gnomAD
rs924502502 CA265559407	820	E>D		No	ClinGen Ensembl
rs955968587 CA265559409	820	E>V		No	ClinGen Ensembl
rs764452668 CA7310491	822	T>M		No	ClinGen ExAC gnomAD
rs1028208566 CA265559406	823	L>S		No	ClinGen gnomAD
CA265559398 rs867002947	824	P>L		No	ClinGen Ensembl
rs964682464 CA265559363	833	S>*		No	ClinGen TOPMed
rs771183788 CA7310485	833	S>P		No	ClinGen ExAC gnomAD
rs761146743 CA7310484	834	S>S		No	ClinGen ExAC TOPMed gnomAD
rs199784699 CA7310482	834	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q6IN85

1 regional properties for Q6IN85

Type	Name	Position	InterPro Accession
domain	Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain	166 - 357	IPR006887

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus	In interphase localized in the cytoplasm and in the nucleus (with higher levels) During metaphase located in pericentriolar regions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
protein phosphatase 4 complex	A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.

1 GO annotations of molecular function

Name	Definition
protein phosphatase activator activity	Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

2 GO annotations of biological process

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6P2K6	Ppp4r3a	Serine/threonine-protein phosphatase 4 regulatory subunit 3A	Mus musculus (Mouse)	PR
Q6DFT3	ppp4r3b	Serine/threonine-protein phosphatase 4 regulatory subunit 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MTDTRRRVKV	YTLNEDRQWD	DRGTGHVSSG	YVERLKGMSL	LVRAESDGSL	LLESKINPNT
70	80	90	100	110	120
AYQKQQDTLI	VWSEAENYDL	ALSFQEKAGC	DEIWEKICQV	QGKDPSVDIT	QDLVDESEEE
130	140	150	160	170	180
RFDDMSSPGL	ELPSCELSRL	EEIAELVASS	LPSPLRREKL	ALALENEGYI	KKLLELFHVC
190	200	210	220	230	240
EDLENIEGLH	HLYEIIKGIF	LLNRTALFEV	MFSEECIMDV	IGCLEYDPAL	SQPRKHREFL
250	260	270	280	290	300
TKTAKFKEVI	PISDPELKQK	IHQTYRVQYI	QDMVLPTPSV	FEENMLSTLH	SFIFFNKVEI
310	320	330	340	350	360
VGMLQEDEKF	LTDLFAQLTD	EATDEEKRQE	LVNFLKEFCA	FSQTLQPQNR	DAFFKTLSNM
370	380	390	400	410	420
GILPALEVIL	GMDDTQVRSA	ATDIFSYLVE	YNPSMVREFV	MQEAQQNDDV	SKKLTEQKIT
430	440	450	460	470	480
SKDILLINLI	IEHMICDTDP	ELGGAVQLMG	LLRTLVDPEN	MLATANKTEK	TEFLGFFYKH
490	500	510	520	530	540
CMHVLTAPLL	ANTTEDKPSK	DDFQTAQLLA	LVLELLTFCV	EHHTYHIKNY	IINKDILRRV
550	560	570	580	590	600
LVLMASKHAF	LALCALRFKR	KIIGLKDEFY	NRYIMKSFLF	EPVVKAFLNN	GSRYNLMNSA
610	620	630	640	650	660
IIEMFEFIRV	EDIKSLTAHV	IENYWKALED	VDYVQTFKGL	KLRFEQQRER	QDNPKLDSMR
670	680	690	700	710	720
SILRNHRYRR	DARTLEDEEE	MWFNTDEDDM	EDGEAVVSPS	DKTKNDDDIM	DPISKFMERK
730	740	750	760	770	780
KLKESEEKEV	LLKTNLSGRQ	SPSFKLSLSS	GTKTNLTSQS	STTNLPGSPG	SPGSPGSPGS
790	800	810	820	830
PGSVPKNTSQ	TAAITTKGGL	VGLVDYPDDD	EDDDEDEDKE	DTLPLSKKAK	FDS