Q6DFT3

PR
Gene name
ppp4r3b
Protein name
Serine/threonine-protein phosphatase 4 regulatory subunit 3
Names
SMEK homolog 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448490
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

705-805 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DFT3

Entry ID Method Resolution Chain Position Source
AF-Q6DFT3-F1 Predicted AlphaFoldDB

No variants for Q6DFT3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DFT3

No associated diseases with Q6DFT3

1 regional properties for Q6DFT3

Type Name Position InterPro Accession
domain Serine/threonine-protein phosphatase 4 regulatory subunit 3-like, central domain 168 - 359 IPR006887

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
protein phosphatase 4 complex A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.

1 GO annotations of molecular function

Name Definition
protein phosphatase activator activity Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

2 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6IN85 PPP4R3A Serine/threonine-protein phosphatase 4 regulatory subunit 3A Homo sapiens (Human) PR
Q6P2K6 Ppp4r3a Serine/threonine-protein phosphatase 4 regulatory subunit 3A Mus musculus (Mouse) PR
10 20 30 40 50 60
MSDTRRRVKV YTLNEDRQWD DRGTGHVSST YVERLKGMSL LVRAESDGSL LLESKINPNT
70 80 90 100 110 120
AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVEVT QDPIDESEEE
130 140 150 160 170 180
RFEEMPETSN LIDLPTCELS KLEEIADLVT SVLSSPIRRE KLALALENEG YIKKLLQLFQ
190 200 210 220 230 240
TCENLDNTEG LHHLYEIIRG ILFLNKAALF EVMFSDECIM DVVGCLEYDP ALAQPKRHRE
250 260 270 280 290 300
FLTKTAKFKE VIPITDSELR QKIHQTYRVQ YIQDVILPTP SVFEENFLST LTSFIFFNKV
310 320 330 340 350 360
EIVSMLQEDE KFLSEVFAQL TDEATDDDKR RELVNFFKEF CAFSQTLQPQ NRDAFFKTLA
370 380 390 400 410 420
NLGILPALEI VMGMDDLQVR AAATDIFSYL VEFSPSMVRE FVMQEAQQSD DDILLINVVI
430 440 450 460 470 480
EQMICDSDPE LGGAVQLMGL LRTLIDPENM LATANKTEKS EFLNFFYNHC MHVLTAPLLA
490 500 510 520 530 540
NTSEDKLEKD AVLGSIKTST VCPDNYQTAQ LLALILELLT FCVEHHTYHI KNYIMNKDLL
550 560 570 580 590 600
RRVLILMNSK HTFLALCALR FMRRIIGLKD EFYNRYIIKG NLFEPVINAL LDNGTRYNLL
610 620 630 640 650 660
NSAIIELFEF IRVEDIKSLT SHIVENFYKA LESIEYVQTF KGLKTRYEQE KDRQSQKLSS
670 680 690 700 710 720
VPSILRSNRF RRDARALEDD EELWFNEDEE EEGEAVVPPV EKTKTEDDFP EGYEKFLETK
730 740 750 760 770 780
KAKELEDKEN LPKRTSVGGF KFTFSHSVSA ANGANSTNSK SVAAHTPPAS SNGSSSKNTS
790 800 810
LTTTVASAKG SLIGLVDYPD DEDEEEEEDT SPRKRPRLGS