Q6NY52
Gene name |
thoc5 (zgc:76912) |
Protein name |
THO complex subunit 5 homolog |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:325064 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NY52
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NY52-F1 | Predicted | AlphaFoldDB |
No variants for Q6NY52
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6NY52 | |||||
No associated diseases with Q6NY52
No regional properties for Q6NY52
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6NY52 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| THO complex part of transcription export complex | The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| positive regulation of DNA-templated transcription, elongation | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSDAVKKRK | PKVIRSEAGT | PETKRGRAES | EQDVRVYNEE | VELEGRDPQQ | DYTLYKETCA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALAKLMSEIQ | ELKTSGAKDG | SAEIELRRKQ | SSIHFITLKK | LNRLAHMRLK | KGRDQTHEAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QRVDVLHLQL | QNLLYEVMHL | QKEIGKCLEF | KSQHEEIELV | SEDEFFQDAP | AEISRPQVTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDHHQLTLAR | LDWELDQRKR | LAEQYKTSLS | SKEKIQKAIE | QKREYLSSLQ | PGLHNIMQAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPVQEYLSMP | FEHMQKQAEV | ARHLPPPLYV | LFVQAGAYGQ | ACDKNLTVSI | RGDVDEAKAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRPPEDSQDD | ESDSDAEEEQ | QNTKRRRPTV | GVQLDDKRKE | MLRRHPLSLG | IDLKCKDGSV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LHLYFYYLMN | LNILTVKTKV | STSVDLSGAI | SAGELLNSES | LLNCLYASDH | GNETPNPANR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YQFDKVGITT | FADYVSDLGH | PYVWVQKLSG | LQFSSDAAQS | ELSGSALSAS | HMEKSMKLLR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GRLQSRLALH | KQFSSLEHSI | VPVSSECQHL | FPAKVVSGLT | RWTMMSHQEF | TELSFVQHVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KAGLVSETDL | FFKAVVERGT | ARLLAAVVVN | PRYPEVTPLF | SLSLLWKGER | SGRTDDNLRA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MESEVNVFRA | ELQGPRPGLQ | LLTNQIQRLC | MCLDVYLETE | SQVSDGSEGP | KEFPREKMCL |
| 670 | 680 | ||||
| RTARGPSRLK | PFKYNHPQGF | FSHR |