AiPD: Autoinhibited Protein Database

Q13769

Gene name	THOC5 (C22orf19, KIAA0983)
Protein name	THO complex subunit 5 homolog
Names	NAC-alpha, Alpha-NAC, Functional spliceosome-associated protein 79, fSAP79, NF2/meningioma region protein pK1.3, Placental protein 39.2, PP39.2, hTREX90
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8563
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-64 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q13769

Entry ID	Method	Resolution	Chain	Position	Source
7APK	EM	330 A	E/M/e/m	1-683	PDB
7ZNK	EM	390 A	E/M/e/m	1-683	PDB
7ZNL	EM	345 A	E/M/e/m	1-683	PDB
AF-Q13769-F1	Predicted				AlphaFoldDB

468 variants for Q13769

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA411149478 rs1178604752	2	S>A		No	ClinGen TOPMed gnomAD
rs1480743800 CA411149474	2	S>L		No	ClinGen gnomAD
COSM1229176 CA411149460 rs1210280856	4	E>*	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs999138709 COSM285710 CA323090144	5	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA411149443 rs999138709	5	S>W		No	ClinGen TOPMed gnomAD
rs769104748 CA10175250	7	K>Q		No	ClinGen ExAC
CA10175249 rs749735788	7	K>R		No	ClinGen ExAC gnomAD
TCGA novel	8	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10175247 rs769756307	9	R>Q		No	ClinGen ExAC gnomAD
rs776121993 CA10175248 COSM1033205	9	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA10175245 rs781503625	12	K>R		No	ClinGen ExAC TOPMed gnomAD
rs757572358 CA10175244	14	I>V		No	ClinGen ExAC
rs1415092767 CA411149064	15	R>Q		No	ClinGen TOPMed
rs747907483 CA10175243	16	S>C		No	ClinGen ExAC gnomAD
CA10175241 rs142300226	17	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs536112773 CA10175240	21	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA411148963 rs1601466000	24	K>E		No	ClinGen Ensembl
CA10175239 rs766346839	25	R>Q		No	ClinGen ExAC gnomAD
CA323090080 rs922178802	25	R>W		No	ClinGen Ensembl
COSM1033203 CA411148927 rs1309125296	27	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs112246632 CA323090036	30	T>I		No	ClinGen Ensembl
rs199976569 CA10175234	31	E>D		No	ClinGen ExAC TOPMed gnomAD
CA10175235 rs761423844	31	E>K		No	ClinGen ExAC gnomAD
rs753777475 CA323082566	35	K>N		No	ClinGen TOPMed gnomAD
CA323082580 rs940880646	35	K>R		No	ClinGen TOPMed gnomAD
CA10175211 rs777339042	36	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs777339042 CA411147924	36	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs377268660 CA10175210	37	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA411147905 rs1199343713	38	S>I		No	ClinGen gnomAD
rs556759265 CA10175208	42	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1368072332 CA411147872	43	V>M		No	ClinGen gnomAD
CA10175206 rs748998599	44	D>E		No	ClinGen ExAC gnomAD
CA10175205 rs61740613	45	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10175203 rs372607483	46	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411147849 rs1601455860	47	D>A		No	ClinGen Ensembl
rs1601455838 CA411147844	48	P>A		No	ClinGen Ensembl
rs781172346 CA10175202	48	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781172346 CA411147840	48	P>R		No	ClinGen ExAC TOPMed gnomAD
CA411147821 rs1478588289	51	D>V		No	ClinGen TOPMed
rs751091978 CA323082506	52	Y>C		No	ClinGen ExAC gnomAD
CA10175200 rs751091978	52	Y>F		No	ClinGen ExAC gnomAD
CA10175201 rs756687525	52	Y>H		No	ClinGen ExAC TOPMed
CA411147798 rs1174951008	55	Y>H		No	ClinGen gnomAD
CA323082492 rs906388926	56	K>R		No	ClinGen TOPMed gnomAD
CA10175198 rs758098447	57	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA411147775 rs1158323663	58	T>A		No	ClinGen gnomAD
rs1158323663 CA411147774	58	T>P		No	ClinGen gnomAD
CA10175196 rs765670316	59	C>Y		No	ClinGen ExAC gnomAD
rs1351386285 CA411147742	63	Q>*		No	ClinGen TOPMed
CA323082453 rs749843086	64	R>K		No	ClinGen Ensembl
rs760624772 CA10175192	66	M>T		No	ClinGen ExAC gnomAD
CA411147676 rs112764070	72	L>P		No	ClinGen TOPMed gnomAD
CA323082448 rs112764070	72	L>Q		No	ClinGen TOPMed gnomAD
CA411147673 rs1302742190	73	K>E		No	ClinGen TOPMed
rs975154119 CA411147668	73	K>N		No	ClinGen TOPMed
rs199913081 CA10175190	73	K>R		No	ClinGen ExAC TOPMed gnomAD
CA10175189 rs145337041	74	S>G		No	ClinGen ESP ExAC gnomAD
CA10175188 rs774614717	74	S>N		No	ClinGen ExAC gnomAD
rs1601455553 CA411147658	75	R>T		No	ClinGen Ensembl
rs769571329 CA10175187	76	G>V		No	ClinGen ExAC TOPMed gnomAD
rs781047344 CA10175185	77	G>R		No	ClinGen ExAC gnomAD
CA10175186 rs781047344	77	G>S		No	ClinGen ExAC gnomAD
CA411147641 rs1222541425	78	K>R		No	ClinGen TOPMed
CA411147608 rs1345529504	81	A>V		No	ClinGen TOPMed
CA10175159 rs748989318	82	I>T		No	ClinGen ExAC TOPMed gnomAD
rs780546677 CA10175158	83	E>G		No	ClinGen ExAC gnomAD
CA411147592 rs1569232611	84	I>V		No	ClinGen Ensembl
CA411147577 rs1489754334	86	E>Q		No	ClinGen gnomAD
CA411147568 rs1342286257	87	R>Q		No	ClinGen TOPMed gnomAD
CA10175157 rs756494460	87	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	88	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10175155 rs750937181	92	C>S		No	ClinGen ExAC gnomAD
CA411147529 rs1292758984	93	V>M		No	ClinGen gnomAD
CA10175154 rs767913507	96	M>I		No	ClinGen ExAC gnomAD
rs1254859816 CA411147502	96	M>K		No	ClinGen TOPMed gnomAD
CA411147507 rs1405687503	96	M>V		No	ClinGen Ensembl
rs1227705649 CA411147494	97	T>I		No	ClinGen TOPMed gnomAD
COSM1318780 CA411147467 rs1198338106	101	L>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1316661059 CA411147456	103	R>Q		No	ClinGen TOPMed
CA411147447 rs1342897913	104	L>F		No	ClinGen gnomAD
CA411147424 rs1327771251	107	I>F		No	ClinGen gnomAD
TCGA novel	108	R>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1490736324 CA411147411	108	R>T		No	ClinGen TOPMed
CA10175152 rs751658280	112	G>A		No	ClinGen ExAC gnomAD
CA411147352 rs1569232455	113	R>S		No	ClinGen Ensembl
CA323081741 rs772172673	116	T>I		No	ClinGen Ensembl
rs150044669 CA10175151	117	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1336135448 CA411146736	119	A>T		No	ClinGen gnomAD
TCGA novel	120	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10175115 rs368727977	121	Q>R		No	ClinGen ESP ExAC TOPMed
rs1046306339 CA323081336	125	A>S		No	ClinGen TOPMed gnomAD
CA10175114 rs781378466	128	L>R		No	ClinGen ExAC gnomAD
CA411146559 rs1439902779	136	E>K		No	ClinGen gnomAD
CA10175111 rs778315400	138	M>L		No	ClinGen ExAC TOPMed
rs1569231833 CA411146473	142	K>N		No	ClinGen Ensembl
rs1446851427 CA411146484	142	K>Q		No	ClinGen TOPMed
TCGA novel	142	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752746788 CA10175109	146	K>R		No	ClinGen ExAC gnomAD
rs1485762985 CA411146408	148	L>F		No	ClinGen gnomAD
CA411146416 rs1440558526	148	L>M		No	ClinGen TOPMed gnomAD
rs1456907506 CA411146381	150	F>L		No	ClinGen TOPMed
rs1365820850 CA411146386	150	F>S		No	ClinGen TOPMed
rs916502833 CA323081311	151	K>R		No	ClinGen TOPMed
rs867784904 CA323078941	155	E>G		No	ClinGen Ensembl
CA411145420 rs1226658879	156	E>D		No	ClinGen gnomAD
CA411145430 rs1266090036	156	E>K		No	ClinGen gnomAD
CA10175083 rs780430300	158	D>E		No	ClinGen ExAC gnomAD
CA10175084 rs749467731	158	D>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	160	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411145375 rs1279507561	161	S>R		No	ClinGen TOPMed
rs764080620 CA10175080	163	E>K		No	ClinGen ExAC TOPMed gnomAD
CA10175081 rs764080620	163	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs758237134 CA10175079	164	E>A		No	ClinGen ExAC TOPMed gnomAD
rs752728914 CA10175078	164	E>D		No	ClinGen ExAC gnomAD
rs139746799 CA323078858	166	Y>H		No	ClinGen ESP gnomAD
CA10175077 rs372080987	170	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA323078839 rs905741778	170	P>S		No	ClinGen TOPMed
CA10175076 rs759147891	171	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10175075 rs776077736	173	I>S		No	ClinGen ExAC gnomAD
rs1569228706 CA411145234	173	I>V		No	ClinGen Ensembl
CA323078811 rs1044210858	177	E>K		No	ClinGen TOPMed
CA10175072 rs200573702	180	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10175070 rs748590222	183	P>R		No	ClinGen ExAC gnomAD
CA411145094 rs1471606311	185	Q>L		No	ClinGen TOPMed
CA10175069 rs774989498	187	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1268231076 COSM1415536 CA411145056	190	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1415535 CA323078793 rs1045252108	190	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1316082102 CA411145038	193	W>R		No	ClinGen gnomAD
CA411145016 rs1259919428	196	E>K		No	ClinGen gnomAD
rs780373178 CA10175066	198	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs749401750 CA10175067	198	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1392027854 CA411144997	199	K>E		No	ClinGen TOPMed
CA411144987 rs1349143790	200	R>K		No	ClinGen TOPMed
CA411144964 rs1332706153	201	L>R		No	ClinGen gnomAD
CA411144967 rs1359083725	201	L>V		No	ClinGen gnomAD
CA411144951 rs1354655401	203	E>D		No	ClinGen TOPMed gnomAD
CA10175041 rs754915675	206	R>*		No	ClinGen ExAC gnomAD
CA411144925 rs758510325	207	E>A		No	ClinGen TOPMed
rs758510325 CA323076910	207	E>G		No	ClinGen TOPMed
TCGA novel	207	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1555964501 CA411144905	210	S>C		No	ClinGen Ensembl
CA10175037 rs750011915	211	N>D		No	ClinGen ExAC gnomAD
CA10175035 rs762036354	219	I>T		No	ClinGen ExAC TOPMed gnomAD
rs751983589 CA10175034	221	V>A		No	ClinGen ExAC TOPMed gnomAD
CA411144798 rs751983589	221	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1442819561 CA411144805	221	V>M		No	ClinGen gnomAD
rs1360019009 CA411144793	222	K>E		No	ClinGen TOPMed
rs763530832 CA10175032	225	Y>S		No	ClinGen ExAC gnomAD
rs1409453695 CA411144723	228	S>G		No	ClinGen gnomAD
CA411144678 rs1376497584	232	R>C		No	ClinGen gnomAD
CA10175030 rs769986095	232	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA323076850 rs762390559	234	N>D		No	ClinGen Ensembl
rs1569226468 CA411144659	234	N>T		No	ClinGen Ensembl
COSM1033197 CA10175007 rs768373921	239	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA411144487 rs775359319	242	P>L		No	ClinGen ExAC gnomAD
CA10175005 rs775359319	242	P>Q		No	ClinGen ExAC gnomAD
rs780729690 CA10175002	244	Q>*		No	ClinGen ExAC gnomAD
CA10175001 rs756774398	248	F>Y		No	ClinGen ExAC gnomAD
CA411144445 rs200730095	249	M>L		No	ClinGen 1000Genomes gnomAD
rs200730095 CA323073336	249	M>V		No	ClinGen 1000Genomes gnomAD
rs201916810 CA10175000	250	P>A		No	ClinGen ExAC TOPMed gnomAD
CA411144433 rs1365742138	250	P>L		No	ClinGen TOPMed gnomAD
rs758773781 CA10174998	251	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1003877736 CA323073303	252	D>N		No	ClinGen TOPMed gnomAD
CA10174997 rs202047216	252	D>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10174996 rs765796771	254	A>T		No	ClinGen ExAC gnomAD
rs1345323199 CA411144409	254	A>V		No	ClinGen TOPMed
rs143914834 CA10174995	255	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA10174994 rs754362956	256	K>E		No	ClinGen ExAC gnomAD
TCGA novel	256	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766479621 CA10174993	257	Q>P		No	ClinGen ExAC gnomAD
rs760679652 CA10174992	258	Y>C		No	ClinGen ExAC gnomAD
rs997537875 CA323073229	260	T>I		No	ClinGen TOPMed gnomAD
rs773425771 CA10174991	261	A>T		No	ClinGen ExAC gnomAD
CA411144348 rs1601424585	263	H>P		No	ClinGen Ensembl
rs887594664 CA323073213	263	H>Q		No	ClinGen TOPMed gnomAD
rs1331762702 CA411144343	264	L>P		No	ClinGen gnomAD
CA10174989 rs199572850	265	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10174990 rs767749920	265	P>S		No	ClinGen ExAC gnomAD
rs769624235 CA10174987	267	P>S		No	ClinGen ExAC gnomAD
CA411144325 rs1365795580	268	L>V		No	ClinGen TOPMed
CA10174986 rs745803082	269	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA411144283 rs1235239045	274	Q>R		No	ClinGen gnomAD
TCGA novel	276	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10174983 rs139046318	277	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA10174981 rs758152713	278	Y>C		No	ClinGen ExAC
rs1328629296 CA411144252	279	G>E		No	ClinGen TOPMed
rs1397107027 CA411144254	279	G>R		No	ClinGen gnomAD
CA323073146 rs922936248	283	D>N		No	ClinGen Ensembl
rs547667686 CA323071096	284	K>T		No	ClinGen gnomAD
CA10174950 rs374911362	285	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141199207 CA10174949	285	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs141199207 CA10174948	285	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10174951 rs374911362	285	T>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1222898567 CA411144137	288	V>M		No	ClinGen TOPMed
CA411144121 rs1477715602	289	A>G		No	ClinGen gnomAD
rs760505803 CA10174945	290	I>S		No	ClinGen ExAC TOPMed gnomAD
rs766234153 CA10174946	290	I>V		No	ClinGen ExAC TOPMed gnomAD
rs576714272 CA10174943	291	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761426189 CA10174942	294	V>M		No	ClinGen ExAC gnomAD
CA411144064 rs1283860586	295	D>N		No	ClinGen TOPMed
CA411143986 rs1336963965	302	K>Q		No	ClinGen gnomAD
CA411143924 rs1362744251	308	Q>*		No	ClinGen gnomAD
CA411143914 rs1217887403	309	D>H		No	ClinGen TOPMed gnomAD
rs1217887403 CA411143915	309	D>N		No	ClinGen TOPMed gnomAD
rs1441651279 CA411143457	311	E>K		No	ClinGen gnomAD
rs986942532 CA323070415	316	A>P		No	ClinGen gnomAD
rs1222781972 CA411143413	317	E>Q		No	ClinGen TOPMed
CA10174916 rs746243178	319	E>*		No	ClinGen ExAC gnomAD
rs760121204 CA10174914	322	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1309562207 CA411143360	323	K>T		No	ClinGen gnomAD
CA10174874 rs768917796	324	R>H		No	ClinGen ExAC gnomAD
CA10174873 rs201126344	326	R>K		No	ClinGen 1000Genomes ExAC
CA10174872 rs780426209	328	T>R		No	ClinGen ExAC gnomAD
rs770788532 CA10174871	329	L>P		No	ClinGen ExAC gnomAD
rs1402129811 CA411143316	331	V>F		No	ClinGen TOPMed
rs746839409 CA323070066	332	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA10174870 rs746839409	332	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA10174869 rs777527911	334	D>N		No	ClinGen ExAC gnomAD
rs758325423 CA10174868	337	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA411143274 rs1463363364	337	R>H		No	ClinGen gnomAD
rs188617925 CA10174866	339	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753433320 CA411143261	339	E>G		No	ClinGen ExAC gnomAD
rs188617925 CA10174865	339	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10174864 rs753433320	339	E>V		No	ClinGen ExAC gnomAD
rs766044119 CA10174863	341	L>P		No	ClinGen ExAC gnomAD
CA411143217 rs1438478102	345	P>L		No	ClinGen gnomAD
rs1193695787 CA411143220	345	P>S		No	ClinGen gnomAD
CA411143206 rs1481835776	347	S>F		No	ClinGen gnomAD
CA411143208 rs1481835776	347	S>Y		No	ClinGen gnomAD
CA10174862 rs760909560	349	M>T		No	ClinGen ExAC gnomAD
CA10174860 rs775277517	351	D>N		No	ClinGen ExAC TOPMed gnomAD
rs769652979 CA323070003	352	L>V		No	ClinGen TOPMed gnomAD
rs534448374 CA10174858	355	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA10174839 rs141439716	358	S>G		No	ClinGen ESP ExAC TOPMed
rs531814697 CA323068385	358	S>N		No	ClinGen gnomAD
rs1159780511 CA411142927	359	V>M		No	ClinGen gnomAD
CA10174838 rs759214429	361	H>G		No	ClinGen ExAC gnomAD
rs1164786658 CA411142909	361	H>Q		No	ClinGen gnomAD
CA10174837 rs775675787	361	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	362	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	368	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420448893 CA411142865	368	M>T		No	ClinGen gnomAD
CA10174836 rs765281455	368	M>V		No	ClinGen ExAC gnomAD
CA10174835 rs759789729	371	N>S		No	ClinGen ExAC gnomAD
CA10174834 rs776783828	372	I>V		No	ClinGen ExAC gnomAD
TCGA novel	373	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10174833 rs751817583	373	M>L		No	ClinGen ExAC gnomAD
rs751817583 CA323068353	373	M>V		No	ClinGen ExAC gnomAD
CA10174831 rs774233122	375	V>I		No	ClinGen ExAC TOPMed gnomAD
VAR_035692 COSM33271 rs1264823745 CA411142781	380	T>K	breast a breast cancer sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt dbSNP gnomAD
rs768550266 CA10174830	381	T>A		No	ClinGen ExAC gnomAD
rs749273094 CA10174829	381	T>I		No	ClinGen ExAC gnomAD
CA10174828 rs779529697	382	A>T		No	ClinGen ExAC gnomAD
CA323068271 rs868069890	382	A>V		No	ClinGen Ensembl
rs755649674 CA10174827	383	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1569217318 CA411142760	384	E>G		No	ClinGen Ensembl
rs138718205 CA10174826	385	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA10174824 rs757589926	387	T>A		No	ClinGen ExAC TOPMed gnomAD
rs764589498 CA10174822	387	T>I		No	ClinGen ExAC gnomAD
CA10174823 rs764589498	387	T>N		No	ClinGen ExAC gnomAD
rs757589926 CA411142745	387	T>P		No	ClinGen ExAC TOPMed gnomAD
CA10174821 rs758948259	388	P>T		No	ClinGen ExAC gnomAD
CA10174820 rs753314101	389	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1166082247 CA411142695	391	A>S		No	ClinGen gnomAD
rs765353596 CA10174819	391	A>V		No	ClinGen ExAC TOPMed gnomAD
rs753186190 CA411142538	393	D>G		No	ClinGen ExAC gnomAD
CA10174802 rs753186190	393	D>V		No	ClinGen ExAC gnomAD
rs1235862266 CA411142531	394	L>W		No	ClinGen gnomAD
rs1371047488 CA411142512	397	P>L		No	ClinGen gnomAD
COSM1714253 CA411142515 rs1420423412	397	P>S	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs779299711 CA10174801	398	D>G		No	ClinGen ExAC TOPMed gnomAD
rs766530547 CA10174798	405	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA10174797 rs750714760	406	P>L		No	ClinGen ExAC TOPMed gnomAD
rs750714760 CA10174796	406	P>R		No	ClinGen ExAC TOPMed gnomAD
rs746820500 CA323065024	408	D>G		No	ClinGen Ensembl
rs1171965251 CA411142436	409	H>R		No	ClinGen gnomAD
CA10174794 rs762752503	411	K>N		No	ClinGen ExAC gnomAD
CA10174795 rs763813845	411	K>R		No	ClinGen ExAC gnomAD
rs1601400267 CA411142412	413	T>P		No	ClinGen Ensembl
rs769647299 CA10174792	417	A>D		No	ClinGen ExAC gnomAD
CA323065015 rs891992262	417	A>S		No	ClinGen TOPMed gnomAD
COSM3800110 CA411142379 rs1182268471	418	N>S	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs185059963 CA10174791	419	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1255003668 CA411142359	421	Q>K		No	ClinGen gnomAD
CA10174790 rs775977624	426	G>A		No	ClinGen ExAC gnomAD
rs759375537 CA10174774	427	I>T		No	ClinGen ExAC gnomAD
TCGA novel	427	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA323064400 rs915644536	428	L>V		No	ClinGen TOPMed gnomAD
rs914364867 CA323064395	432	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs370093602 CA10174771	436	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1601398343 CA411142018	438	G>D		No	ClinGen Ensembl
rs1461234077 CA411142021	438	G>S		No	ClinGen gnomAD
CA10174770 rs772949797	440	P>S		No	ClinGen ExAC gnomAD
CA10174769 rs151070468	442	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1569212908 CA411141992	442	L>S		No	ClinGen Ensembl
CA10174768 rs747885558	444	V>M		No	ClinGen ExAC gnomAD
rs769133043 CA10174766	448	G>A		No	ClinGen ExAC gnomAD
CA10174765 rs749694898	451	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA323064336 rs981738196	451	H>R		No	ClinGen TOPMed
rs1161960965 CA411141913	454	K>R		No	ClinGen TOPMed gnomAD
rs376490705 CA10174763	457	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1432356954 CA411141863	459	Q>R		No	ClinGen gnomAD
TCGA novel	460	T>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368730206 CA10174743	460	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	462	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1284952002 CA411141836	463	A>V		No	ClinGen TOPMed
CA411141832 rs1211125935	464	D>A		No	ClinGen TOPMed
CA10174742 rs781231653	464	D>E		No	ClinGen ExAC gnomAD
CA411141831 rs1211125935	464	D>G		No	ClinGen TOPMed
CA10174741 rs757421498	465	H>N		No	ClinGen ExAC TOPMed gnomAD
CA411141826 rs1601395935	465	H>P		No	ClinGen Ensembl
CA10174740 rs200435124	466	S>L		No	ClinGen ExAC TOPMed gnomAD
rs754679373 CA10174738	467	L>V		No	ClinGen ExAC gnomAD
CA10174737 rs753715867	469	A>T		No	ClinGen ExAC TOPMed gnomAD
CA411141800 rs1282557849	469	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1316281519 CA411141778	472	M>K		No	ClinGen gnomAD
CA411141781 rs1310130069	472	M>L		No	ClinGen gnomAD
rs1304695592 CA411141774	473	E>K		No	ClinGen gnomAD
CA10174735 rs756109353	474	T>I		No	ClinGen ExAC gnomAD
rs8141153 CA323063675 VAR_037134	475	T>S		No	ClinGen UniProt Ensembl dbSNP
CA411141750 TCGA novel rs1376819698	476	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
rs761402487 CA10174732	476	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1378709735 CA411141743	477	K>I		No	ClinGen TOPMed
CA323063670 rs1011510688	478	L>H		No	ClinGen TOPMed
CA323063662 COSM1033193 rs377263785	481	T>I	endometrium [Cosmic]	No	ClinGen cosmic curated ESP
rs1440675913 CA411141707	483	V>E		No	ClinGen gnomAD
CA411141708 rs1452362652	483	V>L		No	ClinGen gnomAD
rs1157508618 CA411141700	484	Q>R		No	ClinGen gnomAD
rs999127606 CA323063646	485	S>F		No	ClinGen Ensembl
CA10174730 rs763840864	486	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1413120428 CA411141687	486	R>H		No	ClinGen gnomAD
CA411141686 rs957238717	487	L>M		No	ClinGen TOPMed gnomAD
rs957238717 CA323063631	487	L>V		No	ClinGen TOPMed gnomAD
CA10174728 rs775806886	488	A>V		No	ClinGen ExAC gnomAD
CA411141648 rs1258909767	492	Q>H		No	ClinGen TOPMed gnomAD
CA10174725 rs372598011	494	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	497	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1186605360 CA411141592 COSM1415530	499	G>D	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
VAR_035693 COSM32545 rs1280359906 CA411141593	499	G>S	breast a breast cancer sample; somatic mutation [Cosmic, UniProt]	No	ClinGen cosmic curated UniProt TOPMed dbSNP
rs553069874 CA323062598	500	I>T		No	ClinGen 1000Genomes
rs765514565 CA10174708	501	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	502	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1393294084 CA411141556	505	S>T		No	ClinGen TOPMed gnomAD
CA411141552 rs1164094918	506	D>Y		No	ClinGen gnomAD
TCGA novel	508	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA323062588 rs779508937	508	Q>P		No	ClinGen TOPMed gnomAD
CA10174706 rs777072161	509	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1190613642 CA411141513	511	F>Y		No	ClinGen gnomAD
CA411141506 rs1450093037	512	P>S		No	ClinGen gnomAD
CA411141502 rs1252334469	513	A>T		No	ClinGen gnomAD
rs376347187 CA10174704	515	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1180052505 CA411141488	515	V>I		No	ClinGen TOPMed
rs773329602 CA10174703	516	V>A		No	ClinGen ExAC gnomAD
rs534672070 CA10174702	518	R>C		No	ClinGen 1000Genomes ExAC gnomAD
COSM3424104 CA10174701 rs748316559	518	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10174699 rs769666296	520	V>A		No	ClinGen ExAC TOPMed gnomAD
rs779292136 CA10174700	520	V>L		No	ClinGen ExAC gnomAD
rs35832657 CA10174698	523	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000964052 rs35832657 CA10174697	523	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA411141432 rs1303373947	524	T>I		No	ClinGen gnomAD
CA10174695 rs751505477	525	V>A		No	ClinGen ExAC TOPMed gnomAD
rs737976 CA10174696 VAR_037135	525	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs737976 CA411141431	525	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1329728104 CA411141423	526	A>D		No	ClinGen TOPMed
rs1569210313 CA411141417	527	H>R		No	ClinGen Ensembl
CA411141419 rs1324607261	527	H>Y		No	ClinGen gnomAD
CA323062476 rs868103810	531	M>T		No	ClinGen TOPMed
rs1182531344 CA411141281	534	H>R		No	ClinGen gnomAD
rs757853867 CA10174676	535	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs747685711 CA10174675	536	T>A		No	ClinGen ExAC gnomAD
rs369317265 CA411141189	542	A>E		No	ClinGen ExAC TOPMed gnomAD
rs369317265 CA411141187	542	A>G		No	ClinGen ExAC TOPMed gnomAD
CA10174673 rs369317265	542	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	545	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	545	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1000173221 CA411141155	546	G>E		No	ClinGen TOPMed gnomAD
rs1000173221 CA323062283	546	G>V		No	ClinGen TOPMed gnomAD
CA10174670 rs756449903	547	D>G		No	ClinGen ExAC gnomAD
rs768173834 CA10174668	548	T>A		No	ClinGen ExAC gnomAD
rs768173834 CA411141146	548	T>P		No	ClinGen ExAC gnomAD
rs762452125 CA10174667	549	N>S		No	ClinGen ExAC gnomAD
CA411141139 rs1450323971	549	N>Y		No	ClinGen gnomAD
CA323062271 rs1025534560	553	M>V		No	ClinGen TOPMed gnomAD
rs1209583592 CA411141099	554	A>T		No	ClinGen TOPMed
rs774555001 CA10174666	554	A>V		No	ClinGen ExAC gnomAD
rs763259869 CA10174664	555	L>P		No	ClinGen ExAC
CA10174662 rs76322387	556	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200216982 CA10174660	558	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1472869432 CA411141052	559	G>V		No	ClinGen gnomAD
rs748133475	560	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1174521957 CA411141043	561	A>T		No	ClinGen TOPMed
CA10174637 rs768108084	563	L>Q		No	ClinGen ExAC gnomAD
rs779657865 CA411140942	566	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779657865 CA10174635	566	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1601377471 CA411140937	567	V>M		No	ClinGen Ensembl
rs1272479310 CA411140931	568	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	570	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411140894 rs1273129690	573	Y>C		No	ClinGen TOPMed
CA411140887 rs1344351446	574	S>Y		No	ClinGen TOPMed gnomAD
TCGA novel	575	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10174633 rs745596484	575	S>T		No	ClinGen ExAC gnomAD
rs781689948 CA10174632	578	P>L		No	ClinGen ExAC
rs1295057252 CA411140864	578	P>S		No	ClinGen gnomAD
CA10174631 VAR_021410 rs1049534	579	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA411140854 rs1353590415	580	F>V		No	ClinGen gnomAD
TCGA novel	581	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	582	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1285867534 CA411140834	583	C>R		No	ClinGen TOPMed
rs1305743131 CA411140830	583	C>S		No	ClinGen gnomAD
CA411140819 rs1431155805	585	N>Y		No	ClinGen gnomAD
CA411140804 rs1390219069	586	W>C		No	ClinGen gnomAD
rs1169850456 CA411140785	589	E>G		No	ClinGen gnomAD
CA411140758 rs1454207115	593	S>G		No	ClinGen gnomAD
rs139476051 CA10174629	595	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA411140731 rs1488989944	596	D>G		No	ClinGen gnomAD
rs758461075 CA10174628	597	N>S		No	ClinGen ExAC gnomAD
COSM173059 rs765406287 CA10174626	599	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA411140712 rs1197793903	599	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10174613 rs200015572	600	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10174612 rs200015572	600	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1437644967 CA411140692	601	M>L		No	ClinGen gnomAD
CA10174610 rs201316386	604	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs975319085 CA323102701	605	V>I		No	ClinGen Ensembl
CA10174609 rs778853698	606	N>S		No	ClinGen ExAC gnomAD
rs755098807 CA10174608	607	V>A		No	ClinGen ExAC gnomAD
rs1569205489 CA411140650	607	V>L		No	ClinGen Ensembl
CA323102697 rs966234485	609	Y>C		No	ClinGen gnomAD
rs1157419489 CA411140628	610	K>R		No	ClinGen gnomAD
rs1273097734 CA411140615	612	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766621463 CA10174606 COSM1682184	616	W>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs893922361 CA323102691	621	L>M		No	ClinGen TOPMed gnomAD
CA411140553 rs893922361	621	L>V		No	ClinGen TOPMed gnomAD
rs150527574 CA10174603	628	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751336548 CA10174604	628	R>W		No	ClinGen ExAC TOPMed gnomAD
rs966723453 CA323102688	630	C>R		No	ClinGen Ensembl
rs1485508597 CA411140496	630	C>S		No	ClinGen gnomAD
rs200906350 CA323102679	631	V>A		No	ClinGen Ensembl
rs376177761 CA10174602	631	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA411140481 rs1569205368	633	L>Q		No	ClinGen Ensembl
rs764590279 CA10174600	634	D>N		No	ClinGen ExAC gnomAD
CA10174597 rs770673888	640	E>K		No	ClinGen ExAC gnomAD
rs746706029 CA10174596	642	H>R		No	ClinGen ExAC gnomAD
CA10174594 rs772553472	644	D>N		No	ClinGen ExAC gnomAD
CA411140385 rs1569205288	647	E>*		No	ClinGen Ensembl
CA10174593 rs748536803	650	K>R		No	ClinGen ExAC gnomAD
rs1569205257 CA411140346	652	F>L		No	ClinGen Ensembl
CA323102621 rs907027013	655	E>K		No	ClinGen gnomAD
rs1370354065 CA411140317	656	K>N		No	ClinGen gnomAD
CA323102620 rs371492673	660	R>L		No	ClinGen ESP ExAC gnomAD
CA10174591 rs371492673	660	R>Q		No	ClinGen ESP ExAC gnomAD
rs1448896186 CA411140292	660	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1190413585 CA411140277	662	F>L		No	ClinGen gnomAD
rs1401556622 CA411140281	662	F>S		No	ClinGen TOPMed
CA411140272 rs1465217490	663	R>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10174573 rs139614127	666	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10174572 rs199857074	673	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	673	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1335369277 CA411140176	674	N>K		No	ClinGen TOPMed
rs1274550104 CA411140179	674	N>S		No	ClinGen TOPMed
rs774619990 CA10174570	676	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10174569 rs548085328	678	G>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA323101333 rs991854809	679	F>L		No	ClinGen Ensembl
CA10174568 rs749853907	683	R>C		No	ClinGen ExAC TOPMed gnomAD
rs749853907 CA411140118	683	R>G		No	ClinGen ExAC TOPMed gnomAD
CA10174567 rs200592450	683	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA323101325 rs200592450	683	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA323101331 rs749853907	683	R>S		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q13769

No regional properties for Q13769

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q13769

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Shuttles between nucleus and cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
THO complex	The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.
THO complex part of transcription export complex	The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.
transcription export complex	The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.

1 GO annotations of molecular function

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

8 GO annotations of biological process

Name	Definition
monocyte differentiation	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.
mRNA export from nucleus	The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
negative regulation of DNA damage checkpoint	Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint.
positive regulation of DNA-templated transcription, elongation	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
primitive hemopoiesis	A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.
RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
viral mRNA export from host cell nucleus	The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8BKT7	Thoc5	THO complex subunit 5 homolog	Mus musculus (Mouse)	PR
Q68FX7	Thoc5	THO complex subunit 5 homolog	Rattus norvegicus (Rat)	PR
Q6NY52	thoc5	THO complex subunit 5 homolog	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSSESSKKRK	PKVIRSDGAP	AEGKRNRSDT	EQEGKYYSEE	AEVDLRDPGR	DYELYKYTCQ
70	80	90	100	110	120
ELQRLMAEIQ	DLKSRGGKDV	AIEIEERRIQ	SCVHFMTLKK	LNRLAHIRLK	KGRDQTHEAK
130	140	150	160	170	180
QKVDAYHLQL	QNLLYEVMHL	QKEITKCLEF	KSKHEEIDLV	SLEEFYKEAP	PDISKAEVTM
190	200	210	220	230	240
GDPHQQTLAR	LDWELEQRKR	LAEKYRECLS	NKEKILKEIE	VKKEYLSSLQ	PRLNSIMQAS
250	260	270	280	290	300
LPVQEYLFMP	FDQAHKQYET	ARHLPPPLYV	LFVQATAYGQ	ACDKTLSVAI	EGSVDEAKAL
310	320	330	340	350	360
FKPPEDSQDD	ESDSDAEEEQ	TTKRRRPTLG	VQLDDKRKEM	LKRHPLSVML	DLKCKDDSVL
370	380	390	400	410	420
HLTFYYLMNL	NIMTVKAKVT	TAMELITPIS	AGDLLSPDSV	LSCLYPGDHG	KKTPNPANQY
430	440	450	460	470	480
QFDKVGILTL	SDYVLELGHP	YLWVQKLGGL	HFPKEQPQQT	VIADHSLSAS	HMETTMKLLK
490	500	510	520	530	540
TRVQSRLALH	KQFASLEHGI	VPVTSDCQYL	FPAKVVSRLV	KWVTVAHEDY	MELHFTKDIV
550	560	570	580	590	600
DAGLAGDTNL	YYMALIERGT	AKLQAAVVLN	PGYSSIPPVF	QLCLNWKGEK	TNSNDDNIRA
610	620	630	640	650	660
MEGEVNVCYK	ELCGPWPSHQ	LLTNQLQRLC	VLLDVYLETE	SHDDSVEGPK	EFPQEKMCLR
670	680
LFRGPSRMKP	FKYNHPQGFF	SHR