Q6KAI0

PR
Gene name
PNP2 (Os02g0617700, LOC_Os02g40460, OJ1014_H03.14)
Protein name
Polyribonucleotide nucleotidyltransferase 2, mitochondrial
Names
Polynucleotide phosphorylase 2, PNPase 2
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

816-903 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6KAI0

Entry ID Method Resolution Chain Position Source
AF-Q6KAI0-F1 Predicted AlphaFoldDB

No variants for Q6KAI0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6KAI0

No associated diseases with Q6KAI0

7 regional properties for Q6KAI0

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 70 - 206 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 387 - 520 IPR001247-2
domain S1 domain 686 - 757 IPR003029
domain Exoribonuclease, phosphorolytic domain 2 209 - 271 IPR015847
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 305 - 384 IPR015848
domain RNA-binding domain, S1 687 - 757 IPR022967-1
domain RNA-binding domain, S1 918 - 981 IPR022967-2

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name Definition
mitochondrial mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
mitochondrial RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P05055 pnp Polyribonucleotide nucleotidyltransferase Escherichia coli (strain K12) PR
Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial Homo sapiens (Human) PR
Q8K1R3 Pnpt1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MSMAVASLRL LARGGRRRAR FPAPLSVPGG RAAFLSGAAE EVAQADAPPP PPPGRKVLES
70 80 90 100 110 120
FREEFEIGGR VISFETGKMA RFANGSVVIS MDDTHVLSTV AAAKSSEPVR DFLPLTVDYQ
130 140 150 160 170 180
EKQYAQGVIP TTYMRREGAP KERELLCGRI IDRPIRPLFP PGFYHEVQVM NATIIMVNVI
190 200 210 220 230 240
SSDGKQDPDV MAANASSAAL MLSDIPWNGP IGVIRVGRID GNFVLNPTVD ELGLSDLNLV
250 260 270 280 290 300
YACSRDKTLM IDVQAREITE RDLQAGMKLA HAEAVKCINP QLRLAKRAGK KKKEYKISLI
310 320 330 340 350 360
SDKSYEKIRT LSEAPIEEVF TDSTYGKFER GEALENITQS VKAKLEEECD EDSLKFLHKA
370 380 390 400 410 420
VDTVRKQVIR KRIIEKGLRV DGRQLDEVRP LYCESSTYPI LHGSALFSRG DTQVLCTVTL
430 440 450 460 470 480
GAPGDAQRLD SIVGPPTKRF MLHYSFPPFS INEVAKRGGL NRREVGHGTL AEKALLAVLP
490 500 510 520 530 540
PEGEFPYTVR VNSEVMASDG STSMASVCGG SMALMDAGIP VREHVAGVSV GLVSEVDQTT
550 560 570 580 590 600
GDISSYRILT DILGLEDHLG DMDFKIAGTR RGITAIQLDI KPAGIPLDII CESLEPARKA
610 620 630 640 650 660
RNQILDRMDQ EISSARAFND GSSPRLATLS FSSDSLRKLL FHRKKIEQET GARVSVSDGT
670 680 690 700 710 720
VTIVAKTQPI MDKAIEKVEF LVGREIEVGR TYKGVVSSIK EYGAFVEFNG GQQGLLHISE
730 740 750 760 770 780
LSHDKVSKVS DVVSVGQVLS LTCIGQDLRG NIKLSLKATL PHAHEKKDLA SNHTDPLPSQ
790 800 810 820 830 840
EVVGWTAVEN MPSKDANAEP SISKDEDNMI EETPGCSTPA VIIRSAAECD AQDVTNDPKK
850 860 870 880 890 900
KRPKVAKSSP KLSKPASERQ EVKRTSAKKT SGASTTAKKN KKEKADSSND VLDAIPEQNK
910 920 930 940 950 960
SNIMNYSSPS NFRSGSMKLG DVVTAKVYQI RAYGLVLELS DGVRGMHKFA ENGHKDFEVG
970 980
EELLVKCSSF NAKGIPVFSL LD