Q6ID18

PR
Gene name
LAC10 (At5g01190, F7J8.170)
Protein name
Laccase-10
Names
Benzenediol:oxygen oxidoreductase 10, Diphenol oxidase 10, Urishiol oxidase 10
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G01190
EC number
1.10.3.2: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

277-394 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6ID18

Entry ID Method Resolution Chain Position Source
AF-Q6ID18-F1 Predicted AlphaFoldDB

38 variants for Q6ID18

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00806135 4 P>Q No 1000Genomes
ENSVATH03000944 13 L>W No 1000Genomes
tmp_5_72452_C_G 21 H>D No 1000Genomes
ENSVATH13864954 38 R>Q No 1000Genomes
ENSVATH06901189 44 Q>R No 1000Genomes
ENSVATH10471568 46 V>I No 1000Genomes
ENSVATH06901190 57 I>V No 1000Genomes
ENSVATH10471569 65 I>V No 1000Genomes
tmp_5_72734_G_A 70 V>I No 1000Genomes
ENSVATH03000953 145 L>P No 1000Genomes
tmp_5_73202_T_A 166 W>R No 1000Genomes
tmp_5_73253_G_T 183 A>S No 1000Genomes
ENSVATH00806137 198 F>L No 1000Genomes
ENSVATH03000970 227 L>M No 1000Genomes
ENSVATH10471666 251 K>N No 1000Genomes
ENSVATH06901200 252 P>L No 1000Genomes
tmp_5_73575_T_C 253 F>S No 1000Genomes
tmp_5_73580_A_C 255 T>P No 1000Genomes
tmp_5_73587_C_T 257 T>I No 1000Genomes
ENSVATH13865066 276 S>P No 1000Genomes
tmp_5_73679_G_A 288 D>N No 1000Genomes
tmp_5_73716_C_A 300 T>N No 1000Genomes
ENSVATH10471669 304 H>R No 1000Genomes
tmp_5_73783_A_C 322 Q>H No 1000Genomes
tmp_5_73785_A_C 323 N>T No 1000Genomes
tmp_5_73848_C_G 344 P>R No 1000Genomes
tmp_5_73855_C_G 346 N>K No 1000Genomes
ENSVATH10471671 349 I>T No 1000Genomes
ENSVATH06901204 368 S>N No 1000Genomes
tmp_5_73928_G_A 371 A>T No 1000Genomes
ENSVATH06901205 374 F>Y No 1000Genomes
tmp_5_74214_T_A 466 F>Y No 1000Genomes
tmp_5_74221_C_A 468 F>L No 1000Genomes
tmp_5_74252_A_C 479 N>H No 1000Genomes
ENSVATH13865067 505 W>R No 1000Genomes
tmp_5_74495_G_A 520 M>I No 1000Genomes
tmp_5_74565_C_T 544 P>S No 1000Genomes
ENSVATH00806138 549 R>L No 1000Genomes

No associated diseases with Q6ID18

8 regional properties for Q6ID18

Type Name Position InterPro Accession
domain Multicopper oxidase, second cupredoxin domain 158 - 307 IPR001117
binding_site Multicopper oxidase, copper-binding site 521 - 532 IPR002355
domain Multicopper oxidase, C-terminal 413 - 541 IPR011706
domain Multicopper oxidase, N-terminal 31 - 144 IPR011707
conserved_site Multicopper oxidases, conserved site 516 - 536 IPR033138
domain Laccase, second cupredoxin domain 158 - 305 IPR034285
domain Laccase, first cupredoxin domain 27 - 143 IPR034288
domain Laccase, third cupredoxin domain 404 - 541 IPR034289

Functions

Description
EC Number 1.10.3.2 With oxygen as acceptor
Subcellular Localization
  • Secreted, extracellular space, apoplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.

3 GO annotations of molecular function

Name Definition
copper ion binding Binding to a copper (Cu) ion.
hydroquinone:oxygen oxidoreductase activity Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5N7A3 LAC6 Laccase-6 Oryza sativa subsp japonica (Rice) PR
Q2R0L2 LAC19 Laccase-19 Oryza sativa subsp japonica (Rice) PR
Q2R0L0 LAC20 Laccase-20 Oryza sativa subsp japonica (Rice) PR
Q8VZA1 LAC11 Laccase-11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FY79 LAC14 Laccase-14 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFD1 LAC9 Laccase-9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFD2 LAC8 Laccase-8 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVFPIRILVL FALLAFPACV HGAIRKYTFN VVTKQVTRIC STKQIVTVNG KFPGPTIYAN
70 80 90 100 110 120
EDDTILVNVV NNVKYNVSIH WHGIRQLRTG WADGPAYITQ CPIKPGHSYV YNFTVTGQRG
130 140 150 160 170 180
TLWWHAHVLW LRATVHGAIV ILPKLGLPYP FPKPHREEVI ILGEWWKSDT ETVVNEALKS
190 200 210 220 230 240
GLAPNVSDAH VINGHPGFVP NCPSQGNFKL AVESGKTYML RLINAALNEE LFFKIAGHRF
250 260 270 280 290 300
TVVEVDAVYV KPFNTDTILI APGQTTTALV SAARPSGQYL IAAAPFQDSA VVAVDNRTAT
310 320 330 340 350 360
ATVHYSGTLS ATPTKTTSPP PQNATSVANT FVNSLRSLNS KTYPANVPIT VDHDLLFTVG
370 380 390 400 410 420
LGINRCHSCK AGNFSRVVAA INNITFKMPK TALLQAHYFN LTGIYTTDFP AKPRRVFDFT
430 440 450 460 470 480
GKPPSNLATM KATKLYKLPY NSTVQVVLQD TGNVAPENHP IHLHGFNFFV VGLGTGNYNS
490 500 510 520 530 540
KKDSNKFNLV DPVERNTVGV PSGGWAAIRF RADNPGVWFM HCHLEVHTTW GLKMAFLVEN
550
GKGPNQSIRP PPSDLPKC