Q6DRF9

PR
Gene name
wdr55
Protein name
WD repeat-containing protein 55
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:445394
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DRF9

Entry ID Method Resolution Chain Position Source
AF-Q6DRF9-F1 Predicted AlphaFoldDB

No variants for Q6DRF9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DRF9

No associated diseases with Q6DRF9

6 regional properties for Q6DRF9

Type Name Position InterPro Accession
repeat WD40 repeat 22 - 63 IPR001680-1
repeat WD40 repeat 70 - 109 IPR001680-2
repeat WD40 repeat 112 - 193 IPR001680-3
repeat WD40 repeat 198 - 235 IPR001680-4
repeat WD40 repeat 280 - 320 IPR001680-5
domain Anaphase-promoting complex subunit 4-like, WD40 domain 42 - 124 IPR024977

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
pharynx development The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
swim bladder development The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ.
thymus development The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O80775 WDR55 WD repeat-containing protein 55 Arabidopsis thaliana (Mouse-ear cress) PR
A2CEH0 poc1b POC1 centriolar protein homolog B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATPTEHEDL SEQEVTEDEF KTPKIRETPE DIKLEAIVNT IAFHPKQDIL AAGDIDGDIY
70 80 90 100 110 120
LFSYSCTEGE NKELWSSGHH LKSCRKVLFS SDGQKLFSVS KDKAIHIMDV EAGKLETRIP
130 140 150 160 170 180
KAHKVPINAM LLIDENIFAT GDDEGTLKVW DMRKGTSFMD LKHHEDYISD ITIDQAKRTL
190 200 210 220 230 240
LTSSGDGTLG VFNIKRRRFE LLSEIQNGDL TSVSIMKRGR KVVCGSGEGT IYIFNWNGFG
250 260 270 280 290 300
ATSDRFAVQA ESVDCIVPIT DSILCAASTD GVIRAINILP NRVVGSIGQH VGEAIEEIAR
310 320 330 340 350 360
CRDTHFLASC AHDELIKFWD ISSLPDEKVN DYRRRKKKDR RLKALSNKAF DTGQNFFAGL
370 380
LDTTEENGKE GENDEDDDDE DSDSGSD