O80775

PR
Gene name
WDR55
Protein name
WD repeat-containing protein 55
Names
Protein WD repeat domain 55, Protein WDR55 homolog
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G34260
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

289-353 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O80775

Entry ID Method Resolution Chain Position Source
AF-O80775-F1 Predicted AlphaFoldDB

21 variants for O80775

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13526186 3 I>T No 1000Genomes
ENSVATH00259518 3 I>V No 1000Genomes
ENSVATH13526190 47 V>I No 1000Genomes
tmp_2_14466229_G_A 49 A>T No 1000Genomes
ENSVATH05654123 49 A>V No 1000Genomes
ENSVATH05654124 64 Q>H No 1000Genomes
tmp_2_14466367_A_T 68 T>S No 1000Genomes
ENSVATH00259519 85 Q>K No 1000Genomes
ENSVATH13526193 92 A>T No 1000Genomes
ENSVATH05654139 140 G>D No 1000Genomes
ENSVATH05654152 237 T>S No 1000Genomes
tmp_2_14467826_C_T 251 P>S No 1000Genomes
ENSVATH13526210 253 R>K No 1000Genomes
ENSVATH13526211 261 H>Y No 1000Genomes
ENSVATH05654155 262 D>N No 1000Genomes
ENSVATH00259523 270 L>H No 1000Genomes
tmp_2_14467998_A_G 272 H>R No 1000Genomes
ENSVATH05654163 300 V>G No 1000Genomes
ENSVATH05654164 301 N>D No 1000Genomes
ENSVATH13526226 335 K>N No 1000Genomes
tmp_2_14468360_A_G 336 T>A No 1000Genomes

No associated diseases with O80775

6 regional properties for O80775

Type Name Position InterPro Accession
repeat WD40 repeat 40 - 79 IPR001680-1
repeat WD40 repeat 82 - 121 IPR001680-2
repeat WD40 repeat 124 - 205 IPR001680-3
repeat WD40 repeat 251 - 292 IPR001680-4
conserved_site WD40 repeat, conserved site 277 - 291 IPR019775
domain Anaphase-promoting complex subunit 4-like, WD40 domain 14 - 100 IPR024977

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
determination of bilateral symmetry The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
developmental vegetative growth The increase in size or mass of non-reproductive plant parts.
embryo development ending in seed dormancy The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
embryo sac development The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
endosperm development The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo.
polar nucleus fusion The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6DRF9 wdr55 WD repeat-containing protein 55 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEIDLGANAF GIDFHPSTNL VAAGLIDGHL HLYRYDSDSS LVRERKVRAH KESCRAVRFI
70 80 90 100 110 120
DDGQRIVTAS ADCSILATDV ETGAQVAHLE NAHEDAVNTL INVTETTIAS GDDKGCVKIW
130 140 150 160 170 180
DTRQRSCSHE FNAHEDYISG MTFASDSMKL VVTSGDGTLS VCNLRTSKVQ SQSEFSEDEL
190 200 210 220 230 240
LSVVIMKNGR KVICGTQNGT LLLYSWGFFK DCSDRFVDLA PNSVDALLKL DEDRLITGCD
250 260 270 280 290 300
NGIISLVGIL PNRIIQPIGS HDYPIEDLAL SHDKKFLGST AHDSMLKLWN LEEILEGSNV
310 320 330 340 350
NSGNASGAAE DSDSDNDGMD LDNDPSKSSK GSKRKTKSKA NTLNATNNFF ADL