Q6DI86

PR
Gene name
Fastkd1 (Kiaa1800)
Protein name
FAST kinase domain-containing protein 1, mitochondrial
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:320720
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

282-445 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DI86

Entry ID Method Resolution Chain Position Source
AF-Q6DI86-F1 Predicted AlphaFoldDB

50 variants for Q6DI86

Variant ID(s) Position Change Description Diseaes Association Provenance
rs27957069 10 L>F No EVA
rs27957070 17 L>V No EVA
rs27957071 34 N>D No EVA
rs222205939 46 T>S No EVA
rs3388560161 68 K>* No EVA
rs3388560912 69 T>A No EVA
rs27957073 89 S>N No EVA
rs3388557174 99 S>N No EVA
rs215234531 105 D>N No EVA
rs3388560230 115 V>A No EVA
rs3388559303 119 H>Y No EVA
rs3388560997 124 A>S No EVA
rs244218142 161 K>N No EVA
rs27957088 200 I>T No EVA
rs3388557168 212 S>P No EVA
rs222542743 222 L>Q No EVA
rs3388559486 230 S>I No EVA
rs3388560137 287 D>V No EVA
rs3388551352 314 T>P No EVA
rs3388560062 330 V>M No EVA
rs3388556713 403 S>C No EVA
rs241304029 421 A>G No EVA
rs27957117 443 Y>C No EVA
rs27957118 452 L>H No EVA
rs3388556776 457 S>N No EVA
rs3388554680 458 T>N No EVA
rs27957119 471 Q>H No EVA
rs3388554885 477 L>Q No EVA
rs236881847 482 N>S No EVA
rs27957120 518 D>N No EVA
rs3391642024 538 L>E No EVA
rs232545066 538 L>Q No EVA
rs27957122 548 I>V No EVA
rs3388556701 565 P>S No EVA
rs3388560059 572 D>G No EVA
rs3388554708 587 C>R No EVA
rs3388554710 590 Y>C No EVA
rs3388557207 619 K>* No EVA
rs226628714 670 R>H No EVA
rs3388554859 693 M>L No EVA
rs3388548804 695 A>VSDG* No EVA
rs3400428526 697 V>SDG* No EVA
rs3391746705 715 T>S No EVA
rs3391719931 740 K>E No EVA
rs3391592430 740 K>N No EVA
rs3391724832 741 S>F No EVA
rs256500983 765 L>F No EVA
rs3388548692 771 F>L No EVA
rs262212135 825 G>A No EVA
rs3388557230 829 S>T No EVA

No associated diseases with Q6DI86

3 regional properties for Q6DI86

Type Name Position InterPro Accession
domain FAST kinase leucine-rich 559 - 630 IPR010622
domain FAST kinase-like protein, subdomain 2 647 - 730 IPR013579
domain RAP domain 761 - 822 IPR013584

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Preferentially localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
ribonucleoprotein granule A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
mitochondrial RNA metabolic process The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
mitochondrial RNA processing The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.
regulation of mitochondrial mRNA stability Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7TMV3 Fastkd5 FAST kinase domain-containing protein 5, mitochondrial Mus musculus (Mouse) PR
Q5M9G9 Tbrg4 FAST kinase domain-containing protein 4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MFRLRSISLL SWRAFPLRPF SCESLITQMQ KCTNEEQVFD LIETNTATLS EQQVGCAFNV
70 80 90 100 110 120
LWQFQKQKTV LEKNVDHVRN HPQFLTLCSI TTNHIPAMSD ATLVDVLYSI KQFAVESHHP
130 140 150 160 170 180
LIEALVTEAW KRLERFDTNV LSIFSTCLAD QHLYFSPLMG KIADIVNRRL ETIQDLRALS
190 200 210 220 230 240
VLMVSISSLI SPCFQERLVI RTELLFDTVN SSKVNIARRI LLFLRNVKYS HYPLLERCNQ
250 260 270 280 290 300
VFIRNMSHLD LESISKILNL YQFLQFHSFE FVEAARGRLA EMTLPSDHPE SFVRLFAALG
310 320 330 340 350 360
PVARPEIKKQ LKSTILLLSE ELSSQQALIV LGAMEDMESR NSHLLKKIVS VLYKHLDNYK
370 380 390 400 410 420
SIELLKIIQA LTFLHFQSKE LFMKLRELLL SRLEASVIPS EISVLVSALS MLPHPHLSET
430 440 450 460 470 480
AVSRIEAVLP QCDFRELNDL VVYLMRWIQS DLVCLASTTG KQLDLLQKLD QLGRHRLQQS
490 500 510 520 530 540
TNLDLLWEEL KSLKGEWLHE SLVEESIAAL LRFMDEIDYS NIAKVASFLS RTNYLNTLLL
550 560 570 580 590 600
DRIASVAIQQ VEKIHPFSVL AIILPFSILN YDPPQKDEFF GACVQCCNSY LGTLDPGTLV
610 620 630 640 650 660
FLGFSLAVLE YFPEDLLKKM FNIEFLARLD SQLEILPSSL SARIQFRLME LNRAVCLECP
670 680 690 700 710 720
ELQVPWFHDR FCQRQFNKDT GVMNGAQQQI YKMLAEVLGG HQCVKPSALS PYYHTVGFEC
730 740 750 760 770 780
ILDKRKKPLP YESHSIAPRK SLGMHWDSRV EPRLPPEAER IAIELLDVRA FCSNIPHLKG
790 800 810 820
KSAMKKRHLE ILGYRVIQIP YFEWNSMAMS TKDARMDYLR EHLFGEGKS