Q5M9G9

PR
Gene name
Tbrg4
Protein name
FAST kinase domain-containing protein 4
Names
Protein TBRG4, Transforming growth factor beta regulator 4
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:360977
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5M9G9

Entry ID Method Resolution Chain Position Source
AF-Q5M9G9-F1 Predicted AlphaFoldDB

2 variants for Q5M9G9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3322518444 217 S>N No EVA
rs3322608406 497 A>S No EVA

No associated diseases with Q5M9G9

3 regional properties for Q5M9G9

Type Name Position InterPro Accession
domain FAST kinase leucine-rich 367 - 437 IPR010622
domain FAST kinase-like protein, subdomain 2 450 - 534 IPR013579
domain RAP domain 559 - 618 IPR013584

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
ribonucleoprotein granule A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

4 GO annotations of biological process

Name Definition
mitochondrial mRNA processing Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs.
mitochondrial RNA processing The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.
mRNA metabolic process The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
regulation of mitochondrial mRNA stability Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6DI86 Fastkd1 FAST kinase domain-containing protein 1, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MAVRLMKQCT CLLREATRLV PTVAPVGRLR LAGVACKTLT SSVSSPSSGS LTELLGKEQV
70 80 90 100 110 120
FTPYPEHQEV DYLIEKATRP EELLELLGGD HSLHHNHAAL ILIRLSYLLS EKPKEKALLV
130 140 150 160 170 180
EDARFQQLVR LVDSQITSVW HGTLVKLLRS LYTLVLPQGS KELRSVEQEV RWRLRRLKYK
190 200 210 220 230 240
HLVFLAESCA PFMKEQHSKE LLAELLRHLE RRWTEISDSR TLVSMMTMAG HLSESLMNRL
250 260 270 280 290 300
EDKCLELVEQ FGPDELRKVL MTLAAQSRRS VPLLRAISYH LVQKPFPMTK GMLLDLAYAY
310 320 330 340 350 360
GKLSFHQTQV AQRLAADLLP FIPSMTPGEV ARCAKSFAFL KWLNLPLFEA FTQHLLNSAQ
370 380 390 400 410 420
DVSLSHLCSV LLAFARLNFH PEQEDQFFNL VHEKLDSVLG SLEPALQVDL VWALCVLQQV
430 440 450 460 470 480
QVAELQTVLH PGLHTRFLES KSPKDQSTFQ KLVHINSTAL LEYPEYKGPF LPASAVAPSP
490 500 510 520 530 540
SPSNKKMTPL QKELQDALKA LLGNNDTGSL EVATQYGWVL DAEVLLDAEG HFLPLRDFVA
550 560 570 580 590 600
PHLAQPVGNQ PLPPGAKRIA FLRWEFPNFN SRSKDLLGRF VLARRHVLAA GFLVVDVPYY
610 620
EWLDLKSEWQ KTAYLKDKMR KAVAEELAK