AiPD: Autoinhibited Protein Database

Gene name	Fastkd5 (Kiaa1792)
Protein name	FAST kinase domain-containing protein 5, mitochondrial
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:380601
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

8-130 (Predicted disordered autoinhibitory region) PR

8-130 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7TMV3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs224287781	3	A>P	No	EVA
rs3388590721	30	W>R	No	EVA
rs231849728	36	T>S	No	EVA
rs213015417	46	C>R	No	EVA
rs249812740	46	C>Y	No	EVA
rs243362233	59	V>I	No	EVA
rs218486616	60	G>V	No	EVA
rs258722797	96	S>P	No	EVA
rs232039644	130	N>T	No	EVA
rs27275338	152	F>S	No	EVA
rs3388580132	179	V>A	No	EVA
rs3392205383	233	H>T*	No	EVA
rs3392277963	245	L>R	No	EVA
rs3392227653	245	L>V	No	EVA
rs3392135975	246	V>E	No	EVA
rs3392277969	252	N>P	No	EVA
rs224953210	261	F>L	No	EVA
rs254413440	283	L>V	No	EVA
rs27275339	300	R>K	No	EVA
rs3388587116	318	G>D	No	EVA
rs3388595097	328	S>T	No	EVA
rs27275340	333	E>Q	No	EVA
rs3388591691	334	F>Y	No	EVA
rs3388593121	371	H>Q	No	EVA
rs3392135937	377	G>L	No	EVA
rs3388588401	440	N>D	No	EVA
rs3388591659	499	K>E	No	EVA
rs3388580116	529	G>D	No	EVA
rs238922680	645	I>V	No	EVA
rs51810104	729	R>H	No	EVA

Type	Name	Position	InterPro Accession
active_site	Phosphoglycerate/bisphosphoglycerate mutase, active site	256 - 265	IPR001345
domain	6-phosphofructo-2-kinase	31 - 251	IPR013079

		Description
EC Number
Subcellular Localization	Mitochondrion matrix, mitochondrion nucleoid	Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrial nucleoid	The region of a mitochondrion to which the DNA is confined.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
ribonucleoprotein granule	A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
rRNA binding	Binding to a ribosomal RNA.

Name	Definition
mitochondrial RNA processing	The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
regulation of mitochondrial mRNA stability	Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q7L8L6	FASTKD5	FAST kinase domain-containing protein 5, mitochondrial	Homo sapiens (Human)	PR
Q6DI86	Fastkd1	FAST kinase domain-containing protein 1, mitochondrial	Mus musculus (Mouse)	PR