Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6A026
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6A026-F1 | Predicted | AlphaFoldDB |
No variants for Q6A026
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6A026 | |||||
No associated diseases with Q6A026
No regional properties for Q6A026
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6A026 | |||
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| anterior/posterior pattern specification | The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| heart morphogenesis | The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| lens development in camera-type eye | The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. |
| metanephros development | The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
| negative regulation of DNA replication | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. |
| neuroblast migration | The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04264 | PDS5 | Sister chromatid cohesion protein PDS5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q29RF7 | PDS5A | Sister chromatid cohesion protein PDS5 homolog A | Homo sapiens (Human) | PR |
| Q4VA53 | Pds5b | Sister chromatid cohesion protein PDS5 homolog B | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFTQPKPAT | ALCGVVSADG | KIAYPPGVKE | ITDKITTDEM | IKRLKMVVKT | FMDMDQDSED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKQQYLPLAL | HLASEFFLRN | PNKDVRLLVA | CCLADIFRIY | APEAPYTSHD | KLKDIFLFIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RQLKGLEDTK | SPQFNRYFYL | LENLAWVKSY | NICFELEDCN | EIFIQLFRTL | FSVINNSHNT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVQMHMLDLM | SSIIMEGDGV | TQELLDSILI | NLIPAHKNLN | KQSFDLAKVL | LKRTVQTIEA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CIANFFNQVL | VLGRSSVSDL | SEHVFDLIQE | LFAIDPQLLL | SVMPQLEFKL | KSNDGEERLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVRLLAKLFG | SKDSDLATQN | RPLWQCFLGR | FNDIHVPVRL | ESVKFASHCL | MNHPDLAKDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TEYLKVRSHD | PEEAIRHDVI | VTIITAAKRD | LALVNDQLLG | FVRERTLDKR | WRVRKEAMMG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LAQLYKKYCL | HGEAGKEAAE | KVSWIKDKLL | HIYYQNSIDD | KLLVEKIFAQ | YLVPHNLETE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ERMKCLYYLY | ASLDPNAVKA | LNEMWKCQNM | LRSHVRELLD | LHKQPTSEAN | CSAMFGKLMT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IAKNLPDPGK | AQDFVKKFNQ | VLGDDEKLRS | QLELLISPTC | SCKQADVCVR | EIARKLANPK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QPTNPFLEMV | KFLLERIAPV | HIDSEAISAL | VKLMNKSIEG | TADDEEEGVS | PDSAIRSGLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLKVLSFTHP | TSFHSAETYE | SLLQCLRMED | DKVAEAAIQI | FRNTGHKIET | DLPQIRSTLI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PILHQKAKRG | TPHQAKQAVH | CIHAIFSNKE | VQLAQIFEPL | SRSLNADVPE | QLITPLVSLG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| HISMLAPDQF | ASPMKSVVAN | FIVKDLLMND | RSTGEKNGKL | WSPDEEVSPE | VLAKVYLLRL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LVRWLLGMKN | NQSKSANSTL | RLLSAMLVSE | GDLTEQKRIS | KSDMSRLRLA | AGSAIMKLAQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EPCYHEIITP | EQFQLCALVI | NDECYQVRQI | FAQKLHKALV | KLLLPLEYMA | IFALCAKDPV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KERRAHARQC | LLKNISIRRE | YIKQNPMATE | KLLSLLPEYV | VPYMIHLLAH | DPDFTRSQDV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DQLRDIKECL | WFMLEVLMTK | NENNSHAFMK | KMAENIKLTR | DAQSPDESKT | NEKLYTVCDV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ALCVINSKSA | LCNADSPKDP | VLPMKFFTQP | EKDFCNDKSY | ISEETRVLLL | TGKPKPTGVL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GTVNKPLSAT | GRKPYVRSAG | TETGSNINAN | SELSPSAGSR | SREQSSEASE | TGVSENEENP |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VRIISVTPVK | NIDTVKNKEI | NSDQSTQGNI | SSDRGKKRIV | TAAGAENIQK | PDEKVDESGP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| PAPSKPRRGR | RPKSESQGNA | TKNDDLNKPV | SKGRKRAAGS | QESLEAGNAK | APKLQDGAKK |
| 1330 | |||||
| AVPAERQIDL | QR |