Q04264

PR
Gene name
PDS5 (YMR076C, YM9582.01C, YM9916.15C)
Protein name
Sister chromatid cohesion protein PDS5
Names
Precocious dissociation of sisters protein 5
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR076C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1151-1277 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q04264

Entry ID Method Resolution Chain Position Source
5FRP X-ray 290 A A/B 1-701 PDB
5FRR X-ray 580 A A/B 1-701 PDB
5FRS X-ray 407 A A 1-701 PDB
AF-Q04264-F1 Predicted AlphaFoldDB

18 variants for Q04264

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-419812 73 R>C No SGRP
s13-419557 158 D>N No SGRP
s13-419274 252 N>S No SGRP
s13-418981 350 A>T No SGRP
s13-418962 356 S>F No SGRP
s13-418870 387 V>I No SGRP
s13-418423 536 S>C No SGRP
s13-418354 559 S>P No SGRP
s13-418336 565 I>V No SGRP
s13-417999 677 K>R No SGRP
s13-417795 745 E>A No SGRP
s13-417534 832 E>G No SGRP
s13-417523 836 V>I No SGRP
s13-417061 990 V>I No SGRP
s13-416928 1034 G>E No SGRP
s13-416745 1095 P>L No SGRP
s13-416371 1220 A>P No SGRP
s13-416347 1228 D>N No SGRP

No associated diseases with Q04264

No regional properties for Q04264

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q04264

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
meiotic recombination initiation complex A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

9 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromatin looping A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
homologous chromosome pairing at meiosis The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
meiotic DNA double-strand break formation The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mitotic sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A Homo sapiens (Human) PR
Q4VA53 Pds5b Sister chromatid cohesion protein PDS5 homolog B Mus musculus (Mouse) PR
Q6A026 Pds5a Sister chromatid cohesion protein PDS5 homolog A Mus musculus (Mouse) PR
10 20 30 40 50 60
MAKGAVTKLK FNSPIISTSD QLISTNELLD RLKALHEELA SLDQDNTDLT GLDKYRDALV
70 80 90 100 110 120
SRKLLKHKDV GIRAFTACCL SDILRLYAPD APYTDAQLTD IFKLVLSQFE QLGDQENGYH
130 140 150 160 170 180
IQQTYLITKL LEYRSIVLLA DLPSSNNLLI ELFHIFYDPN KSFPARLFNV IGGILGEVIS
190 200 210 220 230 240
EFDSVPLEVL RLIFNKFLTY NPNEIPEGLN VTSDCGYEVS LILCDTYSNR MSRHLTKYYS
250 260 270 280 290 300
EIIHEATNDD NNSRLLTVVV KLHKLVLRLW ETVPELINAV IGFIYHELSS ENELFRKEAT
310 320 330 340 350 360
KLIGQILTSY SDLNFVSTHS DTFKAWISKI ADISPDVRVE WTESIPQIIA TREDISKELN
370 380 390 400 410 420
QALAKTFIDS DPRVRRTSVM IFNKVPVTEI WKNITNKAIY TSLLHLAREK HKEVRELCIN
430 440 450 460 470 480
TMAKFYSNSL NEIERTYQNK EIWEIIDTIP STLYNLYYIN DLNINEQVDS VIFEYLLPFE
490 500 510 520 530 540
PDNDKRVHRL LTVLSHFDKK AFTSFFAFNA RQIKISFAIS KYIDFSKFLN NQESMSSSQG
550 560 570 580 590 600
PIVMNKYNQT LQWLASGLSD STKAIDALET IKQFNDERIF YLLNACVTND IPFLTFKNCY
610 620 630 640 650 660
NELVSKLQTP GLFKKYNIST GASIMPRDIA KVIQILLFRA SPIIYNVSNI SVLLNLSNNS
670 680 690 700 710 720
DAKQLDLKRR ILDDISKVNP TLFKDQIRTL KTIIKDLDDP DAEKNDNLSL EEALKTLYKA
730 740 750 760 770 780
SKTLKDQVDF DDTFFFTKLY DFAVESKPEI TKYATKLIAL SPKAEETLKK IKIRILPLDL
790 800 810 820 830 840
QKDKYFTSHI IVLMEIFKKF PHVLNDDSTD IISYLIKEVL LSNQVVGDSK KEIDWVEDSL
850 860 870 880 890 900
LSDTKYSAIG NKVFTLKLFT NKLRSIAPDV PRDELAESFT EKTMKLFFYL IASGGELISE
910 920 930 940 950 960
FNKEFYPTPS NYQTKLRCVA GIQVLKLARI SNLNNFIKPS DIIKLINLVE DESLPVRKTF
970 980 990 1000 1010 1020
LEQLKDYVAN ELISIKFLPL VFFTAYEPDV ELKTTTKIWI NFTFGLKSFK KGTIFERALP
1030 1040 1050 1060 1070 1080
RLIHAIAHHP DIVGGLDSEG DAYLNALTTA IDYLLFYFDS IAAQENFSLL YYLSERVKNY
1090 1100 1110 1120 1130 1140
QDKLVEDEID EEEGPQKEEA PKKHRPYGQK MYIIGELSQM ILLNLKEKKN WQHSAYPGKL
1150 1160 1170 1180 1190 1200
NLPSDLFKPF ATVQEAQLSF KTYIPESLTE KIQNNIKAKI GRILHTSQTQ RQRLQKRLLA
1210 1220 1230 1240 1250 1260
HENNESQKKK KKVHHARSQA DDEEGDGDRE SDSDDDSYSP SNKNETKKGH ENIVMKKLRV
1270
RKEVDYKDDE DDDIEMT