Q4VA53
PR
Gene name |
Pds5b |
Protein name |
Sister chromatid cohesion protein PDS5 homolog B |
Names |
Androgen-induced proliferation inhibitor, Androgen-induced prostate proliferative shutoff-associated protein AS3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:100710 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4VA53
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4VA53-F1 | Predicted | AlphaFoldDB |
49 variants for Q4VA53
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388807838 | 43 | M>K | No | EVA | |
| rs3388807880 | 94 | E>D | No | EVA | |
| rs3388798554 | 95 | A>P | No | EVA | |
| rs3388807865 | 97 | Y>H | No | EVA | |
| rs3388813932 | 116 | G>E | No | EVA | |
| rs3388816734 | 165 | I>M | No | EVA | |
| rs3388811994 | 198 | T>K | No | EVA | |
| rs3396441456 | 220 | A>P | No | EVA | |
| rs3388801019 | 223 | K>E | No | EVA | |
| rs3388814437 | 223 | K>T | No | EVA | |
| rs3388816746 | 232 | Y>* | No | EVA | |
| rs3388801029 | 249 | S>N | No | EVA | |
| rs3388807840 | 264 | N>Y | No | EVA | |
| rs3388813978 | 273 | V>D | No | EVA | |
| rs243355708 | 507 | K>N | No | EVA | |
| rs3396317729 | 508 | D>A | No | EVA | |
| rs3396317799 | 512 | L>V | No | EVA | |
| rs3395674375 | 514 | K>FNLLLVV* | No | EVA | |
| rs3388812033 | 555 | D>V | No | EVA | |
| rs3395674373 | 570 | T>S | No | EVA | |
| rs1135258448 | 584 | T>S | No | EVA | |
| rs1134067771 | 598 | L>* | No | EVA | |
| rs3388814261 | 656 | L>M | No | EVA | |
| rs3388813933 | 770 | I>F | No | EVA | |
| rs3412732058 | 827 | Q>H | No | EVA | |
| rs3388809318 | 870 | I>N | No | EVA | |
| rs3388806686 | 879 | R>I | No | EVA | |
| rs3388806717 | 886 | I>T | No | EVA | |
| rs3388793336 | 904 | Y>N | No | EVA | |
| rs3388801001 | 907 | C>Y | No | EVA | |
| rs3388814284 | 940 | M>K | No | EVA | |
| rs3388781644 | 963 | V>E | No | EVA | |
| rs3388807869 | 963 | V>M | No | EVA | |
| rs3388798573 | 964 | K>M | No | EVA | |
| rs3388801061 | 1070 | D>Y | No | EVA | |
| rs3396561110 | 1086 | E>* | No | EVA | |
| rs3388781682 | 1191 | S>P | No | EVA | |
| rs224391469 | 1204 | P>S | No | EVA | |
| rs3388806689 | 1216 | K>N | No | EVA | |
| rs3388781643 | 1277 | D>V | No | EVA | |
| rs3388811203 | 1289 | G>R | No | EVA | |
| rs3388781688 | 1308 | T>R | No | EVA | |
| rs3388798557 | 1359 | T>A | No | EVA | |
| rs3388807898 | 1363 | E>D | No | EVA | |
| rs3388812044 | 1384 | Q>P | No | EVA | |
| rs252310653 | 1387 | K>Q | No | EVA | |
| rs243049218 | 1389 | I>M* | No | EVA | |
| rs3388801008 | 1432 | S>F | No | EVA | |
| rs260407178 | 1440 | S>I | No | EVA |
No associated diseases with Q4VA53
No regional properties for Q4VA53
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q4VA53 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| lens development in camera-type eye | The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| neuroblast migration | The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04264 | PDS5 | Sister chromatid cohesion protein PDS5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q29RF7 | PDS5A | Sister chromatid cohesion protein PDS5 homolog A | Homo sapiens (Human) | PR |
| Q6A026 | Pds5a | Sister chromatid cohesion protein PDS5 homolog A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHSKTRTND | GKITYPPGVK | EISDKISKEE | MVRRLKMVVK | TFMDMDQDSE | EEKELYLNLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHLASDFFLK | HPDKDVRLLV | ACCLADIFRI | YAPEAPYTSP | DKLKDIFMFI | TRQLKGLEDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSPQFNRYFY | LLENIAWVKS | YNICFELEDS | NEIFTQLYRT | LFSVINNGHN | QKVHMHMVDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MSSIICEGDT | VSQELLDTVL | VNLVPAHKNL | NKQAYDLAKA | LLKRTAQAIE | PYITNFFNQV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LMLGKTSISD | LSEHVFDLIL | ELYNIDSHLL | LSVLPQLEFK | LKSNDNEERL | QVVKLLAKMF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAKDSELASQ | NKPLWQCYLG | RFNDIHVPIR | LECVKFASHC | LMNHPDLAKD | LTEYLKVRSH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPEEAIRHDV | IVSIVTAAKK | DILLVNDHLL | NFVRERTLDK | RWRVRKEAMM | GLAQIYKKYS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LQSAAGKDAA | KQISWVKDKL | LHIYYQNSID | DRLLVERIFA | QYMVPHNLET | TERMKCLYYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YATLDLNAVK | ALNEMWKCQN | LLRHQVKDLL | DLIKQPKTDA | SVKAIFSKVM | VITRNLPDPG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KAQDFMKKFT | QVLEDDEKIR | KQLEALVSPT | CSCKQAEGCV | REITKKLGNP | KQPTNPFLEM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IKFLLERIAP | VHIDTESISA | LIKQVNKSID | GTADDEDEGV | PTDQAIRAGL | ELLKVLSFTH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PISFHSAETF | ESLLACLKMD | DEKVAEAALQ | IFKNTGSKIE | EDFPHIRSAL | LPVLHHKSKK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GPPRQAKYAI | HCIHAIFSSK | ETQFAQIFEP | LHKSLDPSNL | EHLITPLVTI | GHIALLAPDQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FAAPLKSLVA | TFIVKDLLMN | DRLPGKKTTK | LWVPDEEVSP | ETMVKIQAIK | MMVRWLLGMK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NNHSKSGTST | LRLLTTILHS | DGDLTEQGKI | SKPDMSRLRL | AAGSAIVKLA | QEPCYHEIIT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LEQYQLCALA | INDECYQVRQ | VFAQKLHKGL | SRLRLPLEYM | AICALCAKDP | VKERRAHARQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| CLVKNITVRR | EYLKQHAAVS | EKLLSLLPEY | VVPYTIHLLA | HDPDYVKVQD | IEQLKDVKEC |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LWFVLEILMA | KNENNSHAFI | RKMVENIKQT | KDAQGPDDTK | MNEKLYTVCD | VAMNIIMSKS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TTYSLESPKD | PVLPARFFTQ | PDKNFSNTKN | YLPPEMKSFF | TPGKPKTANV | LGAVNKPLSS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| AGKQSQTKSS | RMETVSNASS | SSNPSSPGRI | KGRLDSSEMD | HSENEDYTMS | SPLPGKKSDK |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| REDPDLSELE | KPRSRKKAPV | TDPEEKLGMD | DLTKLVQEQK | PKGSQRGRKR | GRTASDSDEQ |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QWPEEKRHKE | ELLENEDEQN | SPPKKGKRGR | PPKPLGGGTS | KEEPTMKTSK | KGNKKKLVPP |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| VVDDDEEEER | QIGNTEHKSK | SKQHRTSKRA | QQRAESPETS | AVESTQSTPQ | KGRGRPSKAP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| SPSQPPKKIR | VGRSKQVATK | ENDSSEEMDV | LQASSPVSDD | TTQEGAEEED | ISVGNVRRRS |
| SKRERR |