Q68FD5
PR
Gene name |
Cltc |
Protein name |
Clathrin heavy chain 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67300 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q68FD5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5ODS | X-ray | 309 A | A/B/C/D | 1-574 | PDB |
| AF-Q68FD5-F1 | Predicted | AlphaFoldDB |
56 variants for Q68FD5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389185148 | 74 | N>K | No | EVA | |
| rs3389178348 | 116 | L>* | No | EVA | |
| rs3389159020 | 133 | E>V | No | EVA | |
| rs3389190363 | 135 | E>Q | No | EVA | |
| rs3389190335 | 143 | D>E | No | EVA | |
| rs3389158960 | 328 | C>Y | No | EVA | |
| rs3389185099 | 356 | N>S | No | EVA | |
| rs27011957 | 445 | K>T | No | EVA | |
| rs3402165045 | 479 | Y>N | No | EVA | |
| rs3402554297 | 481 | R>S | No | EVA | |
| rs3389190387 | 619 | K>* | No | EVA | |
| rs3389176584 | 620 | A>G | No | EVA | |
| rs3389176555 | 636 | I>M | No | EVA | |
| rs3389203438 | 637 | K>N | No | EVA | |
| rs3389164635 | 740 | Q>R | No | EVA | |
| rs3389153629 | 751 | S>C | No | EVA | |
| rs3389182865 | 801 | E>G | No | EVA | |
| rs3389190399 | 815 | V>S | No | EVA | |
| rs3389199300 | 849 | V>L | No | EVA | |
| rs3389153684 | 850 | E>K | No | EVA | |
| rs3389158948 | 852 | R>G | No | EVA | |
| rs3389187975 | 891 | E>D | No | EVA | |
| rs3389192465 | 904 | V>G | No | EVA | |
| rs3401905204 | 946 | Y>* | No | EVA | |
| rs3401331563 | 947 | L>V | No | EVA | |
| rs3402526287 | 956 | W>L | No | EVA | |
| rs3389192450 | 956 | W>S | No | EVA | |
| rs1132801827 | 974 | V>F | No | EVA | |
| rs3389126292 | 1026 | N>Y | No | EVA | |
| rs3389153686 | 1029 | I>N | No | EVA | |
| rs3389153721 | 1039 | R>C | No | EVA | |
| rs3389153690 | 1095 | A>* | No | EVA | |
| rs3389158986 | 1095 | A>E | No | EVA | |
| rs3389190406 | 1096 | Y>WLR* | No | EVA | |
| rs3389153669 | 1121 | V>M | No | EVA | |
| rs3389182897 | 1153 | L>M | No | EVA | |
| rs3389164638 | 1163 | K>N | No | EVA | |
| rs3389187908 | 1270 | Q>L | No | EVA | |
| rs3402616741 | 1335 | H>Q | No | EVA | |
| rs3402853749 | 1337 | E>Q | No | EVA | |
| rs3402646442 | 1338 | L>V | No | EVA | |
| rs3389191248 | 1398 | V>G | No | EVA | |
| rs3389153720 | 1418 | L>M | No | EVA | |
| rs3402544288 | 1435 | A>G | No | EVA | |
| rs3389153655 | 1466 | S>* | No | EVA | |
| rs3389192381 | 1527 | L>F | No | EVA | |
| rs3389126272 | 1535 | K>M | No | EVA | |
| rs3389176572 | 1547 | T>K | No | EVA | |
| rs3389164566 | 1548 | E>K | No | EVA | |
| rs3389198238 | 1559 | Q>R | No | EVA | |
| rs3389192403 | 1561 | E>G | No | EVA | |
| rs3389203371 | 1582 | V>S | No | EVA | |
| rs3389189958 | 1583 | L>R | No | EVA | |
| rs3389191256 | 1587 | W>* | No | EVA | |
| rs3389187926 | 1588 | R>* | No | EVA | |
| rs3389164603 | 1589 | H>L | No | EVA |
No associated diseases with Q68FD5
13 regional properties for Q68FD5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 537 - 683 | IPR000547-1 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 686 - 828 | IPR000547-2 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 833 - 972 | IPR000547-3 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 979 - 1124 | IPR000547-4 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 1128 - 1269 | IPR000547-5 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 1274 - 1420 | IPR000547-6 |
| repeat | Clathrin, heavy chain/VPS, 7-fold repeat | 1423 - 1582 | IPR000547-7 |
| domain | Clathrin, heavy chain, linker, core motif | 331 - 354 | IPR015348 |
| repeat | Clathrin, heavy chain, propeller repeat | 19 - 56 | IPR022365-1 |
| repeat | Clathrin, heavy chain, propeller repeat | 148 - 187 | IPR022365-2 |
| repeat | Clathrin, heavy chain, propeller repeat | 198 - 234 | IPR022365-3 |
| repeat | Clathrin, heavy chain, propeller repeat | 256 - 288 | IPR022365-4 |
| repeat | Clathrin, heavy chain, propeller repeat | 296 - 330 | IPR022365-5 |
Functions
25 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin coat | A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. |
| clathrin coat of coated pit | The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. |
| clathrin coat of trans-Golgi network vesicle | A clathrin coat found on a vesicle of the trans-Golgi network. |
| clathrin complex | A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. |
| clathrin-coated endocytic vesicle | A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. |
| clathrin-coated pit | A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extrinsic component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| membrane coat | Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| mitotic spindle microtubule | Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. |
| Myb complex | A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| photoreceptor ribbon synapse | A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. |
| presynaptic endocytic zone membrane | The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| T-tubule | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| ankyrin binding | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| clathrin light chain binding | Binding to a clathrin light chain. |
| disordered domain specific binding | Binding to a disordered domain of a protein. |
| double-stranded RNA binding | Binding to double-stranded RNA. |
| heat shock protein binding | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. |
| low-density lipoprotein particle receptor binding | Binding to a low-density lipoprotein receptor. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
| ubiquitin-specific protease binding | Binding to a ubiquitin-specific protease. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| amyloid-beta clearance by transcytosis | The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| clathrin coat assembly | The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. |
| clathrin-dependent endocytosis | An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. |
| Golgi organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
| negative regulation of hyaluronan biosynthetic process | Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. |
| negative regulation of protein localization to plasma membrane | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. |
| receptor internalization | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. |
| receptor-mediated endocytosis | An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. |
| regulation of mitotic spindle organization | Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
| synaptic vesicle endocytosis | A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. |
| transferrin transport | The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P22137 | CHC1 | Clathrin heavy chain | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q00610 | CLTC | Clathrin heavy chain 1 | Homo sapiens (Human) | PR |
| P11442 | Cltc | Clathrin heavy chain 1 | Rattus norvegicus (Rat) | PR |
| P34574 | chc-1 | Probable clathrin heavy chain 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQILPIRFQ | EHLQLQNLGI | NPANIGFSTL | TMESDKFICI | REKVGEQAQV | VIIDMNDPSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PIRRPISADS | AIMNPASKVI | ALKAGKTLQI | FNIEMKSKMK | AHTMTDDVTF | WKWISLNTVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVTDNAVYHW | SMEGESQPVK | MFDRHSSLAG | CQIINYRTDA | KQKWLLLTGI | SAQQNRVVGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MQLYSVDRKV | SQPIEGHAAS | FAQFKMEGNA | EESTLFCFAV | RGQAGGKLHI | IEVGTPPTGN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QPFPKKAVDV | FFPPEAQNDF | PVAMQISEKH | DVVFLITKYG | YIHLYDLETG | TCIYMNRISG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ETIFVTAPHE | ATAGIIGVNR | KGQVLSVCVE | EENIIPYITN | VLQNPDLALR | MAVRNNLAGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EELFARKFNA | LFAQGNYSEA | AKVAANAPKG | ILRTPDTIRR | FQSVPAQPGQ | TSPLLQYFGI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLDQGQLNKY | ESLELCRPVL | QQGRKQLLEK | WLKEDKLECS | EELGDLVKSV | DPTLALSVYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RANVPNKVIQ | CFAETGQVQK | IVLYAKKVGY | TPDWIFLLRN | VMRISPDQGQ | QFAQMLVQDE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EPLADITQIV | DVFMEYNLIQ | QCTAFLLDAL | KNNRPSEGPL | QTRLLEMNLM | HAPQVADAIL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GNQMFTHYDR | AHIAQLCEKA | GLLQRALEHF | TDLYDIKRAV | VHTHLLNPEW | LVNYFGSLSV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EDSLECLRAM | LSANIRQNLQ | ICVQVASKYH | EQLSTQSLIE | LFESFKSFEG | LFYFLGSIVN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FSQDPDVHFK | YIQAACKTGQ | IKEVERICRE | SNCYDPERVK | NFLKEAKLTD | QLPLIIVCDR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FDFVHDLVLY | LYRNNLQKYI | EIYVQKVNPS | RLPVVIGGLL | DVDCSEDVIK | NLILVVRGQF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| STDELVAEVE | KRNRLKLLLP | WLEARIHEGC | EEPATHNALA | KIYIDSNNNP | ERFLRENPYY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DSRVVGKYCE | KRDPHLACVA | YERGQCDLEL | INVCNENSLF | KSLSRYLVRR | KDPELWGSVL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LESNPYRRPL | IDQVVQTALS | ETQDPEEVSV | TVKAFMTADL | PNELIELLEK | IVLDNSVFSE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| HRNLQNLLIL | TAIKADRTRV | MEYINRLDNY | DAPDIANIAI | SNELFEEAFA | IFRKFDVNTS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| AVQVLIEHIG | NLDRAYEFAE | RCNEPAVWSQ | LAKAQLQKGM | VKEAIDSYIK | ADDPSSYMEV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VQAANASGNW | EELVKYLQMA | RKKARESYVE | TELIFALAKT | NRLAELEEFI | NGPNNAHIQQ |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VGDRCYDEKM | YDAAKLLYNN | VSNFGRLAST | LVHLGEYQAA | VDGARKANST | RTWKEVCFAC |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VDGKEFRLAQ | MCGLHIVVHA | DELEELINYY | QDRGYFEELI | TMLEAALGLE | RAHMGMFTEL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| AILYSKFKPQ | KMREHLELFW | SRVNIPKVLR | AAEQAHLWAE | LVFLYDKYEE | YDNAIITMMN |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| HPTDAWKEGQ | FKDIITKVAN | VELYYKAIQF | YLEFKPLLLN | DLLMVLSPRL | DHTRAVNYFS |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| KVKQLPLVKP | YLRSVQNHNN | KSVNESLNNL | FITEEDYQAL | RTSIDAYDNF | DNISLAQRLE |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KHELIEFRRI | AAYLFKGNNR | WKQSVELCKK | DSLYKDAMQY | ASESKDTELA | EELLQWFLQE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| EKRECFGACL | FTCYDLLRPD | VVLETAWRHN | IMDFAMPYFI | QVMKEYLTKV | DKLDASESLR |
| 1630 | 1640 | 1650 | 1660 | 1670 | |
| KEEEQATETQ | PIVYGQPQLM | LTAGPSVAVP | PQAPFGYGYT | APPYGQPQPG | FGYSM |